No effects of acute hyperglycaemia and hyperinsulinaemia on skin microcirculation and endothelial markers in Type II diabetes mellitus

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 64, Issue 2, 2004, Pages 119-127

  Oomen, P H N ^a   Kant, G D ^a   Dullaart, R P F ^a   Cohen Tervaert, J W ^b   Reitsma, W D ^a   Smit, A J ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Capillaroscopy; Capillary permeability; Endothelium; Laser Doppler flowmetry; sICAM 1; Von Willebrand factor

Indexed keywords

ALBUMIN; FLUORESCEIN SODIUM; GLUCOSE; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; VON WILLEBRAND FACTOR;

ADULT; ARTICLE; CAPILLARY DENSITY; CAPILLARY PERMEABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; ENDOTHELIUM LESION; FEMALE; GLUCOSE CLAMP TECHNIQUE; HEMODYNAMICS; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN SENSITIVITY; LASER DOPPLER FLOWMETRY; MALE; MICROALBUMINURIA; MICROCIRCULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SKIN BLOOD FLOW; VIDEODENSITOMETRY;

ANTIGENS; BIOLOGICAL MARKERS; CAPILLARY PERMEABILITY; DIABETES MELLITUS, TYPE 2; ENDOTHELIAL CELLS; FLUORESCENCE; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HEMODYNAMIC PROCESSES; HUMANS; HYPERGLYCEMIA; HYPERINSULINISM; INSULIN; INTERCELLULAR ADHESION MOLECULE-1; LASER-DOPPLER FLOWMETRY; MICROCIRCULATION; MIDDLE AGED; NITRATES; NITRITES; SKIN; SODIUM;

EID: 1842865782     PISSN: 00365513     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365510410004704     Document Type: Article

References (44)

1. Calles-Escandon J, Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev 2001; 22: 36-52.
2. Ruige JB, Assendelft WJ, Dekker JM, Kostense PJ, Heine RJ, Bouter LM. Insulin and risk of cardiovascular disease: a meta-analysis. Circulation 1998; 97: 996-1001.
3. Marfella R, Esposito K, Giunta R, Coppola G, De Angelis L, Farzati B, Paolisso G, Giugliano D. Circulating adhesion molecules in humans: role of hyperglycemia and hyperinsulinemia. Circulation 2000; 101: 2247-51.
4. Williams SB, Goldfine AB, Timimi FK, Ting HH, Roddy MA, Simonson DC, Creager MA. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 1998; 97: 1695-701.
5. Tooke JE. Microvascular function in human diabetes. A physiological perspective. Diabetes 1995; 44: 721-6.
6. Bollinger A, Frey J, Jager K, Furrer J, Seglias J, Siegenthaler W. Patterns of diffusion through skin capillaries in patients with long-term diabetes. N Engl J Med 1982; 307: 1305-10.
7. Feldt-Rasmussen B. Increased transcapillary escape rate of albumin in type 1 (insulin-dependent) diabetic patients with microalbuminuria. Diabetologia 1986; 29: 282-6.
8. Jaap AJ, Shore AC, Tooke JE. Differences in microvascular fluid permeability between long-duration Type I (insulin-dependent) diabetic patients with and without significant microangiopathy. Clin Sci 1996; 90: 113-7.
9. Oomen PHN, Jager J, Hoogenberg K, Dullaart RPF, Reitsma WD, Smit AJ. Capillary permeability is increased in normo-and microalbuminuric type 1 diabetic patients: amelioration by ACE-inhibition. Eur J Clin Invest 1999; 29: 1035-40.
10. Stehouwer CD, Fischer HR, van Kuijk AW, Polak BC, Donker AJ. Endothelial dysfunction precedes development of microalbuminuria in IDDM. Diabetes 1995; 44: 561-4.
11. Oomen PHN, Kant GD, Dullaart RPF, Reitsma WD, Smit AJ. Acute hyperglycemia and hyperinsulinemia enhance vasodilatation in Type 1 diabetes mellitus without increasing capillary permeability and inducing endothelial dysfunction. Microvasc Res 2002; 63: 1-9.
12. Anastasiou E, Lekakis JP, Alevizaki M, Papamichael CM, Megas J, Souvatzoglou A, Stamatelopoulos SF. Impaired endothelium-dependent vasodilatation in women with previous gestational diabetes. Diabetes Care 1998; 21: 2111-5.
13. Caballero AE, Arora S, Saouaf R, Lim SC, Smakowski P, Park JY, King GL, LoGerfo FW, Horton ES, Veves A. Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes 1999; 48: 1856-62.
14. Tooke JE, Goh KL. Endotheliopathy precedes type 2 diabetes. Diabetes Care 1998; 21: 2047-9.
15. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237: E214-23.
16. Stehouwer CD, Lambert J, Donker AJ, van Hinsbergh VW. Endothelial dysfunction and pathogenesis of diabetic angiopathy. Cardiovasc Res 1997; 34: 55-68.
17. Blann AD, Lip GY. Cell adhesion molecules in cardiovascular disease and its risk factors - what can soluble levels tell us? J Clin Endocrinol Metab 2000; 85: 1745-7.
18. Gearing AJ, Hemingway I, Pigott R, Hughes J, Rees AJ, Cashman SJ. Soluble forms of vascular adhesion molecules, E-selectin, ICAM-1, and VCAM-1: pathological significance. Ann N Y Acad Sci 1992; 667: 324-31.
19. Kernick DP, Tooke JE, Shore AC. The biological zero signal in laser Doppler fluximetry. Pflugers Arch 1999; 437: 624-31.
20. Grant RT, Bland EF. Observations on arteriovenous anastomoses in human skin and in the bird's foot with special reference to the reaction to cold. Heart 1931; 15: 385-411.
21. Jager J, Oomen PHN, Sluiter WJ, Reitsma WD, Smit AJ. Improved reproducibility of the "large-windowmethod of assessing transcapillary and interstitial fluorescein diffusion in the skin in healthy subjects and in subjects with insulin-dependent diabetes mellitus. Int J Microcirc Clin Exp 1997; 17: 150-8.
22. Moshage H, Kok B, Huizenga JR, Jansen PL. Nitrite and nitrate determinations in plasma: a critical evaluation. Clin Chem 1995; 41: 892-6.
23. Moshage H, Stegeman CA, Jansen PL. Determination of nitrite and nitrate in stored urine. Clin Chem 1998; 44: 1780-1.
24. Nestler JE, Barlascini CO, Tetrault GA, Fratkin MJ, Clore JN, Blackard WG. Increased transcapillary escape rate of albumin in nondiabetic men in response to hyperinsulinemia. Diabetes 1990; 39: 1212-7.
25. Hilsted J, Christensen NJ, Larsen S. Effect of catecholamines and insulin on plasma volume and intravascular mass of albumin in man. Clin Sci 1989; 77: 149-55.
26. Parving HH, Noer I, Deckert T, Lassen NA. Intravenous insulin has no effect on transcapillary escape rate of albumin and on plasma volume in short-term juvenile diabetics. Diabetes 1979; 28: 282-6.
27. Hilsted J, Bonde-Petersen F, Madsbad S, Parving HH, Christensen NJ, Adelhoj B, Bigler D, Sjontoft E. Changes in plasma volume, in transcapillary escape rate of albumin and in subcutaneous blood flow during hypoglycaemia in man. Clin Sci 1985; 69: 273-7.
28. Catalano C, Muscelli E, Quinones Galvan A, Baldi S, Masoni A, Gibb I, Torffvit O, Seghieri G, Ferrannini E. Effect of insulin on systemic and renal handling of albumin in nondiabetic and NIDDM subjects. Diabetes 1997; 46: 868-75.
29. Scherrer U, Randin D, Vollenweider P, Vollenweider L, Nicod P. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 1994; 94: 2511-5.
30. Yki-Jarvinen H, Utriainen T. Insulin-induced vasodilatation: physiology or pharmacology? Diabetologia 1998; 41: 369-79.
31. de Haan CH, van Dielen FM, Houben AJ, de Leeuw PW, Huvers FC, De Mey JG, Wolffenbuttel BH, Schaper NC. Peripheral blood flow and noradrenaline responsiveness: the effect of physiological hyperinsulinemia. Cardiovasc Res 1997; 34: 192-8.
32. Laakso M, Edelman SV, Brechtel G, Baron AD. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 1992; 41: 1076-83.
33. Rattigan S, Clark MG, Barrett EJ. Hemodynamic actions of insulin in rat skeletal muscle: evidence for capillary recruitment. Diabetes 1997; 46: 1381-8.
34. Baron AD, Tarshoby M, Hook G, Lazaridis EN, Cronin J, Johnson A, Steinberg HO. Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment. Diabetes 2000; 49: 768-74.
35. Serne EH, Stehouwer CD, ter Maaten JC, ter Wee PM, Rauwerda JA, Donker AJ, Gans RO. Microvascular function relates to insulin sensitivity and blood pressure in normal subjects. Circulation 1999; 99: 896-902.
36. Cominacini L, Fratta Pasini A, Garbin U, Davoli A, De Santis A, Campagnola M, Rigoni A, Zenti MG, Moghetti P, Lo Cascio V. Elevated levels of soluble E-selectin in patients with IDDM and NIDDM: relation to metabolic control. Diabetologia 1995; 38: 1122-4.
37. Lim SC, Caballero AE, Smakowski P, LoGerfo FW, Horton ES, Veves A. Soluble intercellular adhesion molecule, vascular cell adhesion molecule, and impaired microvascular reactivity are early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria. Diabetes Care 1999; 22: 1865-70.
38. Rizzoni D, Porteri E, Guelfi D, Muiesan ML, Piccoli A, Valentini U, Cimino A, Girelli A, Salvetti M, De Ciuceis C, Tiberio GA, Giulini SM, Sleiman I, Monteduro C, Rosei EA. Endothelial dysfunction in small resistance arteries of patients with non-insulin-dependent diabetes mellitus. J Hypertens 2001; 19: 913-9.
39. Steiner M, Reinhardt KM, Krammer B, Ernst B, Blann AD. Increased levels of soluble adhesion molecules in type 2 (non-insulin dependent) diabetes mellitus are independent of glycaemic control. Thromb Haemost 1994; 72: 979-84.
40. Jilma B, Dallinger S, Hergovich N, Eichler HG, Richter V, Wagner OF. Effects of hyperinsulinemia on plasma levels of circulating adhesion molecules. J Clin Endocrinol Metab 2000; 85: 1748-51.
41. Aljada A, Saadeh R, Assian E, Ghanim H, Dandona P. Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. J Clin Endocrinol Metab 2000; 85: 2572-5.
42. Khan BV, Harrison DG, Olbrych MT, Alexander RW, Medford RM. Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci USA 1996; 93: 9114-9.
43. Chen NG, Holmes M, Reaven GM. Relationship between insulin resistance, soluble adhesion molecules, and mononuclear cell binding in healthy volunteers. J Clin Endocrinol Metab 1999; 84: 3485-9.
44. Hak AE, Pols HA, Stehouwer CD, Meijer J, Kiliaan AJ, Hofman A, Breteler MM, Witteman JC. Markers of inflammation and cellular adhesion molecules in relation to insulin resistance in nondiabetic elderly: the Rotterdam study. J Clin Endocrinol Metab 2001; 86: 4398-405.