Molecular mechanism of preventive effect of peony root extract on neuron damage

Journal of Herbal Pharmacotherapy

Volumn 4, Issue 1, 2004, Pages 9-20

  Sunaga, Katsuyoshi ^a   Sugaya, Eiichi ^b   Kajiwara, Kagemasa ^c   Tsuda, Tadashi ^a   Sugaya, Aiko ^b   Kimura, Minoru ^c  

^a JOSAI UNIVERSITY   (Japan)

^b Aieido Clinic for Kampo Medicine   (Japan)

^c TOKAI UNIVERSITY   (Japan)

Author keywords

A20 gene; Cobalt focus epilepsy model; EL mouse; Epilepsy; Neuron damage; Neuron protection; Peony root extract

Indexed keywords

APOPTOSIS INHIBITOR; COBALT; NEUROPROTECTIVE AGENT; PAEONIA EXTRACT; PAEONIA LACTIFLORA EXTRACT; PROTEIN A20; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; EPILEPSY; EPILEPTIC FOCUS; GENE EXPRESSION; GENETIC DISORDER; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PAEONIA LACTIFLORA; PLANT ROOT; PRIORITY JOURNAL;

ANIMALS; ANTICONVULSANTS; CEREBRAL CORTEX; COBALT; ELECTROENCEPHALOGRAPHY; EPILEPSY; HIPPOCAMPUS; MICE; MICE, INBRED C57BL; NEURONS; PAEONIA; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; TIME FACTORS;

EID: 1842844407     PISSN: 15228940     EISSN: None     Source Type: Journal    
DOI: 10.1300/J157v04n01_02     Document Type: Article

References (24)

1. Sugaya E, Ishige A, Sekiguchi K, Yuzurihara Y, Iizuka S, Sugimoto A, Hosoya E. Damage of hippocampal neurons caused by cobalt focus in the cerebral cortex of rats. Brain Res. 1988; 459: 196-199.
2. Tsuda T, Sugaya A, Ohguchi H, Kishida N, Sugaya E. Protective effects of peony root extract and its components on neuron damage in the hippocampus induced by the cobalt focus epilepsy model. Exp Neurol. 1997; 146: 518-525.
3. Beyaert R, Heyninck K, Van Hufel S. A20 and A20-binding proteins as cellular inhibitors of nuclear factor-κB-dependent gene expression and apoptosis. Biochem Pharmacol. 2000; 60: 1143-1151.
4. Nishizawa M, Yamagishi T, Horikoshi T, Momma N. Chemical studies on Paeoniae Radix. I. Quantitative determination of glucosides in Paeoniae Radix. Shoyakugaku Zasshi 1979; 33: 65-71.
5. Suzuki, H. Standard compounds for quantitative determination of crude drugs, paeoniflorin, a major principle of peony root. Shoyakugaku Zasshi 1984; 38: 144-148.
6. Nishizawa M, Yamagishi T, Nonaka G, Nishioka I, Nagasawa T, Oura H. Tannins and related compounds. XII. Isolation and characterization of Galloylglucoses from Paeoniae Radix and their effect on urea-nitrogen concentration in rat serum. Chem Pharm Bull. 1983; 31: 2593-2600.
7. Cooper JT, Stroka DM, Brostjan C, Palmetshofer A, Bach FH, Ferran C. A20 blocks endothelial cell activation through a NF-κB-dependent mechanism. J Biol Chem. 1996; 21: 18068-18073.
8. Dixit VM, Green S, Sarma V, Prochownik EV. Tumor necrosis factor-α induction of novel human endothelial cells including a macrophage specific chemotaxin. J Biol Chem. 1990; 265: 2973-2978.
9. Ferran C, Stroka DM, Badrichani AZ, Cooper JT, Wrighton CJ, Soares M, Grey ST, Bach FH. A20 inhibits NF-κB activation in endothelial cells without sensitizing to tumor necrosis factor-mediated apoptosis. Blood 1998; 91: 2249-2258.
10. Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C. A20 inhibits cytokine-induced apoptosis and nuclear factor NF-κB-dependent gene activation in islets. J Exp Med. 1999; 190: 1135-1145.
11. Heyninck KH, Denecker G, Valck DD, Fiers W, Beyaert R. Inhibition of tumor necrosis factor-induced necrotic cell death by the zinc finger protein A20. Anticancer Res. 1999; 19: 2863-2868.
12. Jäättelä M, Mouritzen H, Elling F, Bastholm L. A20 zink finger protein inhibits TNF and IL-1 signaling. J Immunol. 1996; 156: 1166-1173.
13. Lee EG, Boone DL, Chai S, Libby SL, Chien M, Lodolce JP, Ma M. Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice. Science 2000; 289: 2350-2354
14. Sarmat V, Lin Z, Clark L, Rust BM, Tewari M, Noelle RJ, Dixit VM. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J Biol Chem. 1995; 20: 12343-12346.
15. Valck DD, Jin DY, Heyninck K, Craen MV, Contreras R, Fiers W, Jeang KT, Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene 1999; 18: 4182-4190.
16. Varani J, Dame MK, Taylor CG, Sarma V, Merino R, Kunkel RG, Nunez G, Dixit VM. Age-dependent injury in human umbilical vein endothelial cells: Relationship to apoptosis and correlation with a lack of A20 expression. Laboratory Investigation 1995; 73: 851-858.
17. Vincenz C, Dixit VM. 14-3-3 protein associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J Biol Chem. 1996; 21: 20029-20034.
18. Wissing D, Mouritzen H, Jäättelä M. TNF-induced mitochondrial changes and activation of apoptotic proteases are inhibited by A20. Free Radical Biol Med. 1998; 25: 57-65.
19. Yee XH, Harlan JM, Wong F, Karsan A. Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endotheial cells. Blood 1998; 82: 259-265.
20. Tewari M, Wolf FW, Seldin MF, O'Shea KS, Dixit VM, Turka LA. Lymphoid expression and regulation of A20, an inhibitor of programmed cell death. J Immunol. 1995; 154: 1699-1706.
21. Sugaya E, Asou H, Itoh K, Ishige A, Sekiguchi K, Iizuka S, Sugimoto A, Aburada M, Hosoya E, Takagi T, Kajiwara K, Komatsunbara J, Hirano S. Characteristics of primary cultured neurons from embryonic mutant El mouse cerebral cortex. Brain Res. 1987; 406: 20-24.
22. Sugaya E, Sugaya A. Cellular physiology of epileptogenic phenomena and its application to therapy against intractable epilepsy. Comp Biochem Physiol. 1991; 98C: 249-270.
23. Sugaya E, Sugaya A, Yuyama N, Tsuda T, Kajiwara K, Kubota K, Katoh K, Hosoya S, Takagi T, Motoki M. Developmental defects of primary cultured neurons from the cerebral cortex of the El mouse and their amelioration with a herbal formulation, TJ-960. Neurosciences 1992; 18 Suppl.: 111-112.
24. Sugaya E, Sugaya A, Kajiwara K, Tsuda T, Kubota N, Yuyama N, Motoki M, Takagi T, Takagi H, Ookura T, Nagawawa H. Cellular physiology of epileptogenic phenomena-A hint for future therapy by a herbal mixture. In: Tang L, Tang S, eds. Neurochemistry in Clinical Application. New York: Plenum Press, 1994: 165-179.