Chemical modification of coumarin dimer and HIV-1 integrase inhibitory activity

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 12, 2002, Pages 1634-1637

  Mao, Pili Chih Min ^a   Mouscadet, Jean Francois ^b   Leh, Herve ^b   Auclair, Christian ^b   Hsu, Ling Yih ^c  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b Ecole Normale Superieure de Cachan   (France)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Chemical modification; Coumarin dimmer; HIV 1 integrase; Inhibitor

Indexed keywords

3,3' [4 (2 HYDROXYETHOXY)BENZYLIDENE]BIS (4 HYDROXY COUMARIN); 3,3' [4 (4 BROMOBENZOYLOXY)BENZYLIDENE]BIS (4 HYDROXY COUMARIN); 3,3' [4 (4 CHLOROBENZOYLOXY)BENZYLIDENE]BIS (4 HYDROXY COUMARIN); 3,3' [4 (4 METHOXBENZOYLOXY)BENZYLIDENE]BIS (4 HYDROXY COUMARIN); 3,3' [4 (4 METHYLBENZOYLOXY)BENZYLIDENE]BIS (4 HYDROXY COUMARIN); 3,3' [4 (BENZOYLOXY)BENZYLIDENE]BIS (4 HYDROXY COUMARIN); 3,3' [4 [(METHYLSULFONYL)OXY]BENZYLIDENE]BIS (4 HYDROXY COUMARIN); 3,3' [4 [[(1 NAPHTHALYL)SULFONYL]OXY]BENZYLIDENE]BIS (4 HYDROXY COUMARIN); 3,3' [4 [[(2 NAPHTHALYL)SULFONYL]OXY]BENZYLIDENE]BIS (4 HYDROXY COUMARIN); 3,3' [4 [[(4 METHOXYPHENYL)SULFONYL]OXY]BENZYLIDENE]BIS (4 HYDROXY COUMARIN); 3,3' [4 [[(4 METHYLPHENYL)SULFONYL]OXY]BENZYLIDENE]BIS (4 HYDROXY COUMARIN); 3,3' [4 [[(4 TERT BUTYLPHENYL)SULFONYL]OXY]BENZYLIDENE]BIS (4 HYDROXY COUMARIN); COUMARIN DERIVATIVE; DIMER; INTEGRASE; INTEGRASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; CHEMICAL MODEL; DRUG ACTIVITY; DRUG EFFECT; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; ENZYMOLOGY; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

COUMARINS; DIMERIZATION; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1842843322     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.1634     Document Type: Article

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