Ultrastructural study of the remyelinating process following local ethidium bromide injection in the brainstem of dexamethasone-immunosuppressed rats;Estudo ultra-estrutural do processo remielinizante pós-injeç ão de brometo de etídio no tronco encefálico de ratos imunossuprimidos com dexametasona

Arquivos de Neuro-Psiquiatria

Volumn 62, Issue 1, 2004, Pages 131-138

  Fernandes Bondan, Eduardo ^a,e   Lallo, Maria Anete ^a,b   Infante Baz, Erika ^a   Sinhorini, Idércio Luís ^c   Luhers Graça, Dominguita ^d  

^a Universidade Bandeirante de Sao Paulo   (Brazil)

^b PAULISTA UNIVERSITY   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^e NONE   (Brazil)

Author keywords

Central nervous system; Dexamethasone; Ethidium bromide; Immunosuppression; Rats; Remyelination

Indexed keywords

DEXAMETHASONE; ETHIDIUM BROMIDE; GLUTARALDEHYDE; IMMUNOSUPPRESSIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CISTERNA MAGNA; CONTROLLED STUDY; IMMUNOSUPPRESSIVE TREATMENT; MACROPHAGE; NERVE FIBER; NONHUMAN; OLIGODENDROGLIA; RAT; RAT STRAIN; REMYELINIZATION; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

EID: 1842842354     PISSN: 0004282X     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0004-282x2004000100023     Document Type: Article

References (30)

1. Miller DJ, Rodriguez M. Spontaneous and induced remyelination in multiple sclerosis and the Theiler's virus model of central nervous system demyelination. Microsc Res Techn 1995;32:230-245.
2. Yajima K, Suzuki K. Demyelination and remyelination in the rat central nervous system following ethidium bromide injection. Lab Invest 1979;41:385-392.
3. Yajima K, Suzuki K. Ultrastructural changes in oligodendroglia and myelin sheats induced by ethidium bromide. Neuropathol Appl Neurobiol 1979;5:49-62.
4. Blakemore WF. Ethidium bromide induced demyelination in the cord of the rat. Neuropathol Appl Neurobiol 1982;8:365-375.
5. Graça DL, Blakemore WF. Delayed remyelination in rat spinal cord following ethidium bromide injection. Neuropathol Appl Neurobiol 1986;12:593-605.
6. Graça DL. The presence of lymphocytes in a toxically induced demyelinating process of the central nervous system. Micr Eletr y Biol Cel 1988;12:17-22.
7. Reynolds R, Wilkin GP. Cellular reaction to an acute demyelination/remyelination lesion of the rat brain stem: localisation of GD, ganglioside immunoreactivity. J Neurosci Res 1993;36:405-422.
8. Gevehr CG, Graça DL, Pereira LAVD. Desmielinização e remielinização após múltiplas injeções intramedulares de brometo de etídio em ratos Wistar. Arq Neuropsiquiatr 1997;55:189-202.
9. Pereira LAVD, Dertkigill MS, Graça DL, Cruz-Höffling MA. Dynamics of remyelination in the brain of adult rats after exposure to ethidium bromide. J Submicrosc Cytol Pathol 1998;30:341-348.
10. Bondan EF, Lallo MA, Graça DL. Efeitos do brometo de etídio no tronco encefálico de ratos Wistar imunossuprimidos com ciclosporina. Coleção Cadernos de Estudos e Pesquisas UNIP 1998:1-46.
11. Bondan EF, Lallo MA, Sinhorini IL, Pereira LAVD, Graça DL. The effect of cyclophosphamide on the rat brainstem remyelination following local ethidium bromide injection in Wistar rats. J Submicrosc Cytol Pathol 2000;32:603-612.
12. Graça DL, Bondan EF, Pereira LAVD, Fernandes CG, Maiorka PC. Behaviour of oligodendrocytes and Schwann cells in an experimental model of toxic demyelination of the central nervous system. Arq Neuropsiquiatr 2001;59:358-361.
13. Gilson J, Blakemore WF. Failure of remyelination in areas of demyelination produced in the spinal cord of old rats. Neuropathol Appl Neurobiol 1993;19:173-181.
14. Offner H, Konat G. Myelin changes induced by incubation of brain slices with serum. Neurochem Int 1983;5:45-49.
15. Jordan FL, Thomas WE. Brain macrophages: questions of origin and interrelationship. Brain Res Rev 1988;13:165-178.
16. Thomas WE. Brain macrophages: evaluation of microglia and their functions. Brain Res Rev 1992;17:61-74.
17. Bignami A, Dahl D. Glial cells in the central nervous system and their reaction to injury. Austin: RG Landes 1994:1-108.
18. Benveniste EN. Cytokines: influence on glial cell gene expression and function. In: Blalock JE. (ed) Neuroimmunoendocrinology. Basel: Karger 1992:106-153.
19. Triarhou LC, Herndon RM. The effect of drugs on experimental remyelination. Neurology (Suppl. 1) 1984;34:578.
20. Triarhou LC, Herndon RM. Effect of macrophage inactivation on the neuropathology of lysolecithin-induced demyelination. Brit J Exp Pathol 1985;66:293-305.
21. Jeffery ND, Blakemore WF. Remyelination of mouse spinal cord axons demyelinated by local injection of lysolecithin. J Neurocytol 1995;24:775-781.
22. Ludwin SK. Chronic demyelination inhibits remyelination in the central nervous system. An analysis of contributing factors. Lab Invest 1980;43:382-387.
23. Blakemore WF, Crang AJ, Franklin RJM, Tang K, Ryder S. Glia cell transplants that are subsequently rejected can be used to influence regeneration of glial cell environments in the CNS. Glia 1995;13:79-91.
24. Herndon RM, Price DL, Weiner LP. Regeneration of oligodendroglia during recovery from demyelinating disease. Science 1977;195:693-694.
25. Raine CS, Scheinberg L, Waltz JM. Multiple sclerosis. Oligodendrocyte survival and proliferation in an active established lesion. Lab Invest 1981;45:534-546.
26. Arenella LS, Herndon RM. Mature oligodendrocytes. Division following experimental demyelination in adult animal. Arch Neurol 1994;41:1162-1165.
27. Wolswijk G, Noble M. Cooperation between PDGF and FGF converts slowly dividing O-2A adult progenitor cells to rapidly dividing cells with characteristics of O-2A perinatal progenitor cells. J Cell Biol 1992;118:889-900.
28. Alonso G. Prolonged corticosterone treatment of adult rats inhibits the proliferation of oligodendrocyte progenitors present throughout white and gray matter regions of the brain. Glia 2000;31:219-231.
29. Jung-Testas I, Schumacher M, Robel P, Baulieu EE. Actions of steroid hormones and growth factors on glial cells of the central and peripheral nervous system. J Steroid Biochem Molec Biol 1994;48:145-154.
30. Perry VH, Andersson PB, Gordon S. Macrophages and inflammation in the central nervous system. TINS 1993;16:268-273.