Enantioseparation of Hydrochloride Salts Using Carbon Dioxide-Based Mobile Phases with On-Line Polarimetric Detection

Chirality

Volumn 16, Issue 4, 2004, Pages 263-266

  Geiser, Fiona ^a   Shah, Rekha ^b  

^a Johnson Matthey   (United States)

^b LLC   (United States)

Author keywords

Carbon dioxide; Chiralpak AD H; Enantioseparation; Flurbiprofen; Polarimetric detector; Propranolol HCl; Supercritical fluid chromatography (SFC); Thioridazine HCl; Tramadol HCl

Indexed keywords

2 PROPANOL; ALCOHOL; AMINE; CARBON DIOXIDE; CHLORIDE; FLURBIPROFEN; HEPTANE; METHANOL; PROPRANOLOL; THIORIDAZINE; TRAMADOL;

CHIRALITY; CONFERENCE PAPER; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; POLARIMETRY; PRIORITY JOURNAL; RACEMIZATION; SUPERCRITICAL FLUID CHROMATOGRAPHY; SYNTHESIS; ULTRAVIOLET SPECTROSCOPY;

EID: 1842842124     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.20025     Document Type: Conference Paper

References (5)

1. Geiser F, Schultz M, Betz L, Shaimi M, Lee J, Champion W Jr. Direct, preparative enantioselective chromatography of propranolol hydrochloride and thioridazine hydrochloride using carbon dioxide-based mobile phases. Chromatogr A 1999;865:227-233.
2. Edkins TJ, Fronheiser M, Bobbitt DR, Mills JE, Rossi TM. Enantiomeric quantitation without separation of tramadol via laser-based polarimetry. Enantiomer 1996;1:97-107.
3. Yun KYe, Lord B, Stringham RW. Memory effect of mobile phase additives in chiral separations on a Chiralpak AD column. Chromatogr A 2002;945:139-146.
4. Ceccato A, Vanderbist F, Pabst J-Y, Streel B. Enantiomeric determination of tramadol and its main metabolite O-desmethyltramadol in human plasma by liquid chromatography-tandem mass spectrometry. Chromatogr B 2000;748:65-76.
5. Wilson WH. Direct enantiomeric resolution of ibuprofen and flurbiprofen by packed column SFC. Chirality 1994;6:216-219.