Decreased cell proliferation in the dentate gyrus of α7 nicotinic acetylcholine receptor heterozygous mice

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 28, Issue 3, 2004, Pages 517-520

  Koike, Kaori ^a   Hashimoto, Kenji ^a   Okamura, Naoe ^a   Ohgake, Shintaro ^a   Shimizu, Eiji ^a   Koizumi, Hiroki ^a   Komatsu, Naoya ^a   Iyo, Masaomi ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

7 nicotinic acetylcholine receptors; 7 Nicotinic receptor subunit; 5 bromo 2 deoxyuridine; BrdU; Cell proliferation; Dentate gyrus; GCL; Granule cell layer; Hippocampus; nAChRs; Neurogenesis; Neuronal nicotinic receptor

Indexed keywords

BROXURIDINE; CHOLINERGIC RECEPTOR; NICOTINIC RECEPTOR; PROTEIN SUBUNIT;

ADULTHOOD; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DENTATE GYRUS; GRANULE CELL; HETEROZYGOSITY; HIPPOCAMPUS; IMMUNOCOMPETENT CELL; MALE; MOUSE; NONHUMAN; PROTEIN FUNCTION; STATISTICAL SIGNIFICANCE; WILD TYPE;

ANIMALS; ANTIMETABOLITES; BROMODEOXYURIDINE; CELL DIVISION; DENTATE GYRUS; HETEROZYGOTE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MICE; RECEPTORS, NICOTINIC;

EID: 1842839743     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2004.01.003     Document Type: Article

References (16)

1. Bettany J.H., Levin E.D. Ventral hippocampal alpha 7 nicotinic receptor blockade and chronic nicotine effects on memory performance in the radial-arm maze. Pharmacol. Biochem. Behav. 70:2001;467-474.
2. Broide R.S., Leslie F.M. The alpha7 nicotinic acetylcholine receptor in neuronal plasticity. Mol. Neurobiol. 20:1999;1-16.
3. Cordero-Erausquin M., Marubio L.M., Klink R., Changeux J.P. Nicotinic receptor function: new perspectives from knockout mice. Trends Pharmacol. Sci. 21:2000;211-217.
4. Gage F.H. Neurogenesis in the adult brain. J. Neurosci. 22:2002;612-613.
5. Gould E., Beylin A., Tanapat P., Reeves A., Shors T.J. Learning enhances adult neurogenesis in the hippocampal formation. Nat. Neurosci. 2:1999;260-265.
6. Jones S., Sudweeks S., Yakel J.L. Nicotinic receptors in the brain: correlating physiology with function. Trends Neurosci. 22:1999;555-561.
7. Kempermann G. Why new neurons? Possible functions for adult hippocampal neurogenesis. J. Neurosci. 22:2002;635-638.
8. Kitagawa H., Takenouchi T., Azuma R., Wesnes K.A., Kramer W.G., Clody D.E., Burnett A.L. Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers. Neuropsychopharmacology. 28:2003;542-551.
9. Kuhn H.G., Dickinson-Anson H., Gage F.H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16:1996;2027-2033.
10. Levin E.D. Nicotinic receptor subtypes and cognitive function. J. Neurobiol. 53:2002;633-640.
11. Levin E.D., Bettegowda C., Blosser J., Gordon J. AR-R17779, an alpha7 nicotinic agonist, improves learning and memory in rats. Behav. Pharmacol. 10:1999;675-680.
12. Nakagawa S., Kim J.E., Lee R., Malberg J.E., Chen J., Steffen C., Zhang Y.J., Nestler E.J., Duman R.S. Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J. Neurosci. 22:2002;3673-3682.
13. Paylor R., Nguyen M., Crawley J.N., Patrick J., Beaudet A., Orr-Urtreger A. Alpha7 nicotinic receptor subunits are not necessary for hippocampal- dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice. Learn. Mem. 5:1998;302-316.
14. Picciotto M.R., Caldarone B.J., Brunzell D.H., Zachariou V., Stevens T.R., King S.L. Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacol. Ther. 92:2001;89-108.
15. Shors T.J., Miesegaes G., Beylin A., Zhao M., Rydel T., Gould E. Neurogenesis in the adult is involved in the formation of trace memories. Nature. 410:2001;372-376.
16. Stevens K.E., Kem W.R., Mahnir V.M., Freedman R. Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology (Berl.). 136:1998;320-327.