Role of androgen on blood flow and capillary structure in rat seminal vesicles

Tohoku Journal of Experimental Medicine

Volumn 202, Issue 3, 2004, Pages 193-201

  Ono, Yoshihiro ^a   Suzuki, Kazuhiro ^a   Kashiwagi, Bunzo ^a   Shibata, Yasuhiro ^a   Ito, Kazuto ^a   Fukabori, Yashitatsu ^a   Yamanaka, Hidetoshi ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Blood flow; Capillary; Seminal vesicles; Transmission electron microscopy

Indexed keywords

ANDROGEN; TESTOSTERONE;

ARTICLE; CAPILLARY; CASTRATION; COMPUTER ANALYSIS; CONTROLLED STUDY; HORMONE ACTION; IMAGE ANALYSIS; LASER DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; MORPHOLOGY; NONHUMAN; ORGAN BLOOD FLOW; ORGAN WEIGHT; RAT; SEMINAL VESICLE; STATISTICAL SIGNIFICANCE; SUPPLEMENTATION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CAPILLARIES; LASER-DOPPLER FLOWMETRY; MALE; ORCHIECTOMY; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; SEMINAL VESICLES; TESTOSTERONE;

EID: 1842834264     PISSN: 00408727     EISSN: None     Source Type: Journal    
DOI: 10.1620/tjem.202.193     Document Type: Article

References (27)

1. Barroso, C.P., Afonso, F., Caldas, M.C., Pinho, M., Mata, L. & Gulbenkian, S. (1999) Suppression of 125I-vasoactive intestinal polypeptide binding sites in arteries of the hamster seminal vesicle following castration. Histochem. J., 31, 271-276.
2. Bentvelsen, F.M., Brinkmann, A.O., van der Schoot, P., van der Linden, J.E.T.M., van der Kwast, T.H., Boersma, F.H., Schröder, F.H. & Nijman, J.M. (1995) Developmental pattern and regulation by androgens of androgen receptor expression in the urogenital tract of the rat. Mol. Cell. Endocrinol., 113, 245-253.
3. Brown, L.F., Yeo, K.T., Berse, B., Morgentaler, A., Dvorak, H.F. & Rosen, S. (1995) Vascular permeability factor (vascular endothelial growth factor) is strongly expressed in the normal male genital tract and is present in substantial quantities in semen. J. Urol., 154, 576-579.
4. Burchardt, M., Burchardt, T., Chen, M.W., Hayek, O.R., Knight, C., Shabsigh, A., Taille, A. & Buttyan, R. (2000) Vascular endothelial growth factor-A expression in the rat ventral prostate gland and the early effects of castration. Prostate, 43, 184-194.
5. Chamness, S.L., Maguire, B.S., Ricker, D.D., Burnett, A.L., Crone, J.K., Chang, T.S. & Dembeck, C.L. (1995) The effect of androgen on nitric oxide synthase in the male reproductive tract of the rat. Fertil. Steril., 63, 1101-1107.
6. Coffy, D.S. & Walsh, P.C. (1990) Clinical and experimental studies in benign prostatic hyperplasia. Urol. Clin. North. Am., 17, 461-476.
7. Ehrlichman, R.J., Issacs, J.T. & Coffy, D.S. (1981) Differences in the effects of estradiol on dihydrotestosterone-induced growth of the castrated rat and dog. Invest. Urol., 18, 466-470.
8. Fukabori, Y., Yan, G., Nikolaropoulos, S., Wang, F., McBride, G., Yamanaka, H. & McKeehan, W.L. (1994) Control of prostate epithelial cell growth by androgen and KGF/FGF-7 during tumor progression. In: Proceedings of 5th Tokyo Symposium on Prostatic Cancer: Fundamental approach to the diagnosis and treatment of prostate cancer and BPH, edited by K. Imai, J. Shimazaki & P.J. Karr, Adenine Press, New York, pp. 123-132.
9. Guijarro, L.G., Rodriguez-Pena, M.S. & Prieto, J.C. (1991) Characterization of vasoactive intestinal peptide receptors in rat seminal vesicle. Am. J. Physiol., 260, E286-E291.
10. Harris, P.D. & Longnecker, D.E. (1971) Significance of precapillary sphincter activity for microcirculatory function. Microvas. Res., 3, 385-395.
11. Hayek, O.R., Shabsigh, A., Kaplan, S.A., Kiss, A.J., Chen, M.W., Burchardt, T., Burchardt, M., Olsson, C.A. & Buttyan, R.B. (1999) Castration induces acute vasoconstriction of blood vessels in the prostate concomitant with a reduction of prostatic nitric oxide synthase activity. J. Urol., 162, 1527-1531.
12. Häggström, S., Wikström, P., Bergh, A. & Damber, J.E. (1998) Expression of vascular endothelial growth factor and its receptors in the rat ventral prostate and Dunning R3327 PAP adenocarcinoma before and after castration. Prostate, 36, 71-79.
13. John, H., Suter, S. & Hauri, D. (2002) Effect of radical prostatectomy on urethral blood flow. Urology, 59, 566-569.
14. Joseph, I.B.J.K., Nelson, J.B., Denmeade, S.R. & Issacs, J.T. (1997) Androgen regulates vascular endothelial growth factor content in normal and malignant prostatic tissue. Clin. Cancer Res., 3, 2507-2511.
15. Lissbrant, I.F., Häggström, S., Damber, J.E. & Bergh, A. (1998) Testosterone stimulates angiogenesis and vascular regrowth in the ventral prostate in castrated adult rats. Endocrinology, 139, 451-456.
16. Mata, L.R. (1995) Dynamics of the seminal vesicle epithelium. Int. Rev. Cytol., 160, 267-302.
17. Nakano, K., Fukabori, Y., Itoh, N., Lu, W., Kan, M., Mckeehan, W.L. & Yamanaka, H. (1999) Androgen-stimulated human prostate epithelial growth mediated by stromal-derived fibroblast growth factor-10. Endocr J., 46, 405-413.
18. Ono, Y., Suzuki, K., Yuasa, H., Kurokawa, K., Fukabori, Y. & Yamanaka, H. (2003) Ultrastructural changes in subepithelial capillaries and their surrounding stroma in rat prostate and seminal vesicle after castration. Tohoku J. Exp. Med., 201, 29-38.
19. Ono, Y., Suzuki, K., Kashiwagi, B., Shibata, Y., Ito, K., Fukabori, Y. & Yamanaka, H. (2004) Androgen-dependent blood flow control and morphological changes of the capillaries in rat prostate. Int. J. Androl., 26, 50-56.
20. Partin, A.W. & Rodriguez, R. (2002) The molecular biology, endocrinology, and physiology of the prostate and seminal vesicles. In: Campbell's Urology, 8th ed., edited by P.C. Walsh, A.B. Retik, E.D. Vaugham, Jr. & A.J. Wein, WB Saunders, Philadelphia, pp. 1237-1296.
21. Sar, M., Lubahn, D.B., French, F.S. & Wilson, Z.M. (1990) Immunohistochemical localization of the androgen receptor in rat and human tissues. Endocrinology, 127, 3180-3186.
22. Shabsigh, A., Tanji, N., D'agati, V., Burchardt, M., Rubin, M., Goluboff, E.T., Heitjan, D., Kiss, A. & Buttyan, R. (1999a) Early effects of castration on the vascular system of the rat ventral prostate gland. Endocrinology, 140, 1920-1926.
23. Shabsigh, A., Tanji, N., D'agati, V., Burchardt, T., Burchardt, M., Hayek, O., Shabsigh, R. & Buttyan, R. (1999b) Vascular anatomy of the rat ventral prostate. Anat. Rec., 256, 403-411.
24. Stern, M.D. (1975) In vivo evaluation of microcirculation by coherent light scattering. Nature, 254, 56-58.
25. Suzuki, K., Ito, K., Ichinose, Y., Kurokawa, K., Suzuki, T., Imai, K., Yamanaka, H. & Honma, S. (1995) Endocrine environment of benign prostatic hyperplasia: prostate size and volume are correlated with serum estrogen concentration. Scand. J. Urol. Nephrol., 29, 65-68.
26. Thomson, A.A. & Cunha, G.R. (1991) Prostatic growth and development are regulated by FGF10. Developemant, 126, 3693-3701.
27. Walsh, P.C. & Wilson, J.D. (1976) The induction of prostatic hypertrophy in the dog with androstendiol. J. Clin. Invest., 57, 1093-1097.