Behavioral consequences of methyllycaconitine in mice: A model of α7 nicotinic acetylcholine receptor deficiency

Life Sciences

Volumn 74, Issue 25, 2004, Pages 3133-3139

  Chilton, Melissa ^a   Mastropaolo, John ^a   Rosse, Richard B ^a,b   Bellack, Alan S ^a,c   Deutsch, Stephen I ^a,b,c  

^a DEPARTMENT OF VETERANS AFFAIRS   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Cognition; Methyllycaconitine; Mouse; Negative symptoms; Schizophrenia; Stereotypic behavior

Indexed keywords

BUNGAROTOXIN RECEPTOR; METHYLLYCACONITINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; BEHAVIOR DISORDER; CLIMBING; CONTROLLED STUDY; GNAWING; GROOMING; LOCOMOTION; MALE; MASTICATION; MOUSE; NONHUMAN; PROTEIN DEFICIENCY; REARING; SNIFFING; STATISTICAL SIGNIFICANCE;

ACONITINE; ANIMALS; BEHAVIOR, ANIMAL; BINDING SITES; BRAIN; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MODELS, ANIMAL; MOTOR ACTIVITY; NICOTINIC ANTAGONISTS; RECEPTORS, NICOTINIC;

ATAXIA;

EID: 1842813306     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.11.012     Document Type: Article

References (16)

1. Adler L.E., Hoffer L.D., Wiser A., Freedman R. Normalization of auditory physiology by cigarette smoking in schizophrenic patients. Am J Psychiatry. 150:1993;1856-1861.
2. Adler L.E., Olincy A., Waldo M., Harris J.G., Griffith J., Stevens K., Flach K., Nagamoto H., Bickford P., Leonard S., Freedman R. Schizophrenia, sensory gating, and nicotine receptors. Schizophrenia Bulletin. 24(2):1998;189-202.
3. Damaj M.I., Glassco W., Dukat M.et al. Pharmacological characterization of nicotine-induced seizures in mice. JPET. 291:1999;1284-1291.
4. 7 nicotinic acetylcholine receptor: Therapeutic Implications. Clinical Neuropharmacology. 26(5):2002;277-283.
5. 7 nicotinic receptor abnormality in schizophrenia. Israel Journal of Psychiatry.
6. Freedman R., Adler L.E., Bickford P., Byerley W., Coon H., Cullum C.M., Griffith J.M., Harris J.G., Leonard S., Miller C.et al. Schizophrenia and nicotinic receptors. Harvard Rev Psychiatry. 2:1994;179-192.
7. Leonard S., Adams C., Breese C.R., Adler L.E., Bickford P., Byerley P., Coon H., Griffith J.M., Miller C., Myles-Worsley M.et al. Nicotine receptor function in schizophrenia. Schizophrenia Bulletin. 22(3):1996;421-445.
8. 7 acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch Gen Psychiatry. 59:2002;1085-1096.
9. Marubio L.M., Changeux J.-P. Nicotinic acetylcholine receptor knockout mice as animal models for studying receptor function. Eur J Pharmacol. 393:2000;113-121.
10. Orr-Urtreger A., Goldner F.M., Saeki M., Lorenzo I., Goldberg L., DeBiasi M., Dani J.A., Patrick J.W., Beaudet A.L. Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents. J Neurosci. 17:1997;9165-9171.
11. Paylor R., Nguyen M., Crawley J.N., Patrick J., Beaudet A., Orr-Urtreger A. α7 Nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice. Learning and Memory. 5(4):1998;302-316.
12. Rosse R.B., Deutsch S.I. Adjuvant galantamine administration improves negative symptoms in a patient with treatment-refractory schizophrenia. Clinical Neuropharmacology. 25(5):2002;272-275.
13. Sherr J.D., Myers C., Avalia M.T., Elliott A., Blaxton T.A., Thaker G.K. The effects of nicotine on specific eye tracking measures in schizophrenia. Biol Psychiatry. 52:2002;721-728.
14. 7 nicotinic agonist, improves deficient sensory inhibition in DBA/2 mice. Biol Psychiatry. 50:2001;493-500.
15. Simosky J.K., Stevens K.E., Adler L.E., Freedman R. Clozapine improves deficient inhibitory auditory processing in DBA/2 mice, via a nicotinic cholinergic mechanism. Psychopharmacology. 165:2003;386-396.
16. 7 nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology. 136:1998;320-327.