New benzo[5,6]pyrrolizino[1,2-b]quinolines as cytotoxic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 9, 2004, Pages 2363-2365

  Perzyna, Aurore ^a   Klupsch, Frédérique ^a   Houssin, Raymond ^a   Pommery, Nicole ^a   Lemoine, Amélie ^a   Hénichart, Jean Pierre ^a  

^a UNIV LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; QUINOLINE DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 1842790834     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.01.097     Document Type: Article

References (17)

1. Wall M.E., Wani M.C., Cook C.E., Palmer K.H., McPhail A.T., Sim G.A. J. Am. Chem. Soc. 88:1966;3888.
2. Ma Z.Z., Hano Y., Nomura T., Chen Y.J. Heterocycles. 46:1997;541.
3. Kobayashi J., Cheng J.F., Nakamura H., Ohizumi Y., Hirata Y., Sasaki T., Ohta T., Nozoe S. Tetrahedron Lett. 29:1988;1177.
4. Utsugi T., Aoyagi K., Asao T., Okazaki S., Aoyagi Y., Sano M., Wierzba K., Yamada Y. Jpn. J. Cancer Res. 88:1997;992.
5. Jonckers T.H.M., van Miert S., Cimanga K., Bailly C., Colson P., De Pauw-Gillet M.-C., van Den Heuvel H., Claeys M., Lemière F., Esmans E.L., Rozenski J., Quirijnen L., Maes L., Dommisse R., Lemière G.L.F., Vlietinck A., Pieters L. J. Med. Chem. 45:2002;3497.
6. Peczynska-Czoch W., Pognan F., Kaczmarek L., Boratynski J. J. Med. Chem. 37:1994;3503.
7. Bush J.A., Long B.H., Catino J.J., Bradner W.T., Tomita K. J. Antibiot. (Tokyo). 40:1987;668.
8. Leteurtre F., Sackett D.L., Madalengoitia J., Kohlhagen G., MacDonald T., Hamel E., Paull K.D., Pommier Y. Biochem. Pharmacol. 49:1995;1283.
9. Maulard C., Urien S., Bastian G., Tillement J.-P. Biochem. Pharmacol. 40:1990;895.
10. Thomas D.W., Biemann K. Tetrahedron. 24:1968;4223.
11. Klinke P., Gibian H. Chem. Ber. 94:1961;26.
12. Bird T.G.C., Bruneau P., Crawley G.C., Edwards M.P., Foster S.J., Girodeau J.M., Kingston J.F., McMillan R.M. J. Med. Chem. 34:1991;2176.
13. Remers W.A., Weiss M.J. J. Med. Chem. 8:1965;700.
14. Chackal S., Houssin R., Hénichart J.-P. J. Org. Chem. 67:2002;3502.
15. 5 cells/well. The tested compounds were added to the culture medium and incubation was performed for 72 h. Cell growth was assessed by numeration on Nageotte hemacytometer.
16. 5 cells/well. After 24 h, the tested compounds were added to the culture medium for 72 h. Cell growth was assessed by the colorimetric MTT test.
17. Perzyna A., Marty C., Facompré M., Goossens J.-F., Pommery N., Colson P., Houssier C., Houssin R., Hénichart J.-P., Bailly C. J. Med. Chem. 45:2002;5809.