A Pathologist's Perspective on Bone Marrow Aspiration and Biopsy: I. Performing a Bone Marrow Examination

Journal of Clinical Laboratory Analysis

Volumn 18, Issue 2, 2004, Pages 70-90

  Riley, Roger S ^a   Hogan, Thomas F ^b   Pavot, Dawn R ^a   Forysthe, Robert ^a   Massey, Davis ^a   Smith, Eileen ^a   Wright Jr , Lou ^c   Ben Ezra, Jonathan M ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b MAYO CLINIC   (United States)

^c MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anesthetics, local; Biopsy needle; Bone marrow examination; Bone marrow pathology; Diagnostic tests

Indexed keywords

PEROXIDASE;

BLEEDING; BONE MARROW BIOPSY; BONE MARROW TRANSPLANTATION; CANCER CHEMOTHERAPY; CYTOCHEMISTRY; CYTOGENETICS; DEVICE; FLOW CYTOMETRY; FOLLOW UP; GIEMSA STAIN; HEART TAMPONADE; HEMATOLOGIC MALIGNANCY; ILIAC CREST; INFECTION; LOCAL ANESTHESIA; MICROSCOPY; PAIN; QUALITY CONTROL; REVIEW; STERNUM; TECHNIQUE;

ADULT; ANESTHESIA, LOCAL; BIOPSY, NEEDLE; BONE MARROW EXAMINATION; CHILD; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HUMANS; ILIUM; PATHOLOGY, CLINICAL; STERNUM; TIBIA;

EID: 1842790087     PISSN: 08878013     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcla.20008     Document Type: Review

References (125)

1. Williams WJ, Nelson DA. Examination of the marrow. In: Williams WJ, Beutler E, Erslev AJ, Lichtman MA, editors. Hematology. New York: McGraw-Hill, Inc.; 1972. p 24-31.
2. Knowles S, Hoffbrand AV. Bone-marrow aspiration and trephine biopsy (1). Br Med J 1980;281:204-205.
3. Knowles S, Hoffbrand AV. Bone-marrow aspiration and trephine biopsy (2). Br Med J 1980;281:280-281.
4. Beckstead JH. The bone marrow biopsy. A diagnostic strategy. Arch Pathol Lab Med 1986;110:175-179.
5. Barekman CL, Fair KP, Cotelingam JD. Comparative utility of diagnostic bone-marrow components: a 10-year study. Am J Hematol 1997;56:37-41.
6. Bain BJ. Bone marrow aspiration. J Clin Pathol 2001;54:657-663.
7. Bain BJ. Bone marrow trephine biopsy. J Clin Pathol 2001;54:737-742.
8. Nanda A, Basu S, Marwaha N. Bone marrow trephine biopsy as an adjunct to bone marrow aspiration. J Assoc Physicians India 2002;50:893-895.
9. Dalrymple J. On the microscopical character of mollities ossium. Dublin Quarterly J Med Sci 1846;85-95.
10. Arinkin MI. Die intravitale untersuchungsmethodik des knochenmarks. Folia Haematol 1929;38:233-240.
11. Arinkin MI. The intravital method of examining the bone marrow. Clin Orthop 1970;73:3-7.
12. Raich PC. Bone marrow needle biopsy: method and indications. Wis Med J 1974;73:S155-S160.
13. Custer RP. Biopsy of the bone marrow. In: An atlas of the blood and bone marrow. Philadelphia: W.B. Saunders Co.; 1974, p 537-551.
14. Reich C. A clinical atlas of sternal bone marrow. Chicago: Abbott Laboratories; 1946.
15. Custer RP. Studies on the structure and function of bone marrow: bone marrow biopsy. Am J Med Sc 1933;185:617-624.
16. McFarland W, Dameshek W. Biopsy of bone marrow with the Vim-Silverman needle. JAMA 1958;166:1464-1466.
17. Ellis LD, Jensen WN, Westerman MF. Needle biopsy of bone and bone marrow. An experience with 1,445 biopsies. Arch Intern Med 1964;114:213-214.
18. Jamshidi K, Swaim WR. Bone marrow biopsy with unaltered architecture: a new biopsy device. J Lab Clin Med 1971;77:335-342.
19. Jamshidi K, Windschitl HE, Swaim WR. A new biopsy needle for bone marrow. Scand J Haematol 1971;8:69-71.
20. Birch CD, Fischer S, Zibell A, Jensen ME. Diagnostic bone-marrow studies extended routinely by iliac crest biopsy, using the method of Schaadt-Fischer. Acta Pathol Microbiol Immunol Scand [A] 1982;90:229-234.
21. Goldenberg AS, Rishton M. Bone-marrow biopsy needle incorporating a snare-coil specimen-capturing device: description and preclinical studies. Biomed Instrum Technol 1999;33:522-529.
22. Goldenberg AS, Tiesinga JJ. Clinical experience with a new specimen capturing bone marrow biopsy needle. Am J Hematol 2001;68:189-193.
23. De Wolf-Peeters C. Bone marrow trephine interpretation: diagnostic utility and potential pitfalls. Histopathology 1991;18:489-493.
24. Hyun BH, Stevenson AJ, Hanau CA. Fundamentals of bone marrow examination. Hematol Oncol Clin North Am 1994;8:651-663.
25. Diebold J, Molina T, Camilleri-Broet S, Le Tourneau A, Audouin J. Bone marrow manifestations of infections and systemic diseases observed in bone marrow trephine biopsy review. Histopathology 2000;37:199-211.
26. Nichols L, Florentine B, Lewis W, et al. Bone marrow examination for the diagnosis of mycobacterial and fungal infections in the acquired immunodeficiency syndrome. Arch Pathol Lab Med 1991;115:1125-1132.
27. Kilby JM, Marques MB, Jaye DL, et al. The yield of bone marrow biopsy and culture compared with blood culture in the evaluation of HIV-infected patients for mycobacterial and fungal infections. Am J Med 1998;104:123-128.
28. Benito N, Nunez A, de Gorgolas M, et al. Bone marrow biopsy in the diagnosis of fever of unknown origin in patients with acquired immunodeficiency syndrome. Arch Intern Med 1997;157:1577-1580.
29. Luther JM, Lakey DL, Larson RS, et al. Utility of bone marrow biopsy for rapid diagnosis of febrile illnesses in patients with human immunodeficiency virus infection. South Med J 2000;93:692-697.
30. Akpek G, Lee SM, Gagnon DR, Cooley TP, Wright DG. Bone marrow aspiration, biopsy, and culture in the evaluation of HIV-infected patients for invasive mycobacteria and histoplasma infections. Am J Hematol 2001;67:100-106.
31. Penchansky L. Bone marrow biopsy in the metastatic work-up of solid tumors in children. Cancer 1984;54:1447-1448.
32. Pittaluga S, Tierens A, Dodoo YL, Delabie J, De Wolf-Peeters C. How reliable is histologic examination of bone marrow trephine biopsy specimens for the staging of non-Hodgkin lymphoma? A study of hairy cell leukemia and mantle cell lymphoma involvement of the bone marrow trephine specimen by histologic, immunohistochemical, and polymerase chain reaction techniques. Am J Clin Pathol 1999;111:179-184.
33. Cheung NK. Detecting neuroblastoma using bone marrow aspiration and bone marrow biopsy. J Pediatr Hematol Oncol 2000;22:86-88.
34. Valdes-Sanchez M, Nava-Ocampo AA, Palacios-Gonzalez RV, et al. Diagnosis of bone marrow metastases in children with solid tumors and lymphomas. Aspiration, or unilateral or bilateral biopsy? Arch Med Res 2000;31:58-61.
35. Sale GE, Buckner CD. Pathology of bone marrow in transplant recipients. Hematol Oncol Clinics North Amer 1988;2:735-756.
36. Snover DC. Biopsy interpretation in bone marrow transplantation. Pathol Annu 1989;24:63-101.
37. van den Berg H, Kluin PM, Vossen JM. Early reconstitution of haematopoiesis after allogeneic bone marrow transplantation: a prospective histopathological study of bone marrow biopsy specimens. J Clin Pathol 1990;43:365-369.
38. Liso V, Albano F, Pastore D, et al. Bone marrow aspirate on the 14th day of induction treatment as a prognostic tool in de novo adult acute myeloid leukemia. Haematologica 2000;85:1285-1290.
39. Sloane JP, Norton J. The Pathology of bone marrow transplantation. Histopathology 1993;22:201-209.
40. Wintrobe MM. Clinical hematology. Philadelphia: Lean and Febiger; 1967.
41. Rywlin AW, Marvan P, Robinson MJ. A simple technique for the preparation of bone marrow smears and sections. Am J Clin Pathol 1970;53:389.
42. Paulman PM. Bone marrow sampling. Am Fam Physician 1989;40:85-89.
43. Bird AR, Jacobs P. Trephine biopsy of the bone marrow. S Afr Med J 1983;64:271-276.
44. Williamson PJ, Smith AG. Bone marrow aspiration and biopsy. Br J Hosp Med 1991;46:328-330.
45. Foucar K. Bone marrow pathology. Chicago: ASCP Press; 1995.
46. O'Rourke A. Bone marrow procedure guide. Oncol Nurs Forum 1986;13:66-67.
47. Scarlato M. Bone marrow examination: how to make it less frightening for your patients ... and you. Nursing 1976;6:13
48. Hawkins C. Patients' reactions to their investigations: a study of 504 patients. Br Med J 1979;2:638-640.
49. Pamanan SV. Relief of anxiety during invasive diagnostic procedures. N Engl J Med 1980;302:754-755.
50. Markus S. Taking the fear out of bone marrow examinations. Nursing 1981;11:64-67.
51. Zeltzer LK, Altman A, Cohen D, et al. American Academy of Pediatrics report of the subcommittee on the management of pain associated with procedures in children with cancer. Pediatrics 1990;86:826-831.
52. McCarthy AM, Cool VA, Petersen M, Bruene DA. Cognitive behavioral pain and anxiety interventions in pediatric oncology centers and bone marrow transplant units. J Pediatr Oncol Nurs 1996;13:3-14.
53. Rywlin AM. Histopathology of the bone marrow. Boston: Little, Brown & Co.; 1976.
54. Douglas DD, Risdall RJ. Bone marrow biopsy technic. Artifact induced by aspiration. Am J Clin Pathol 1984;82:92-94.
55. Brynes RK, McKenna RW, Sundberg RD. Bone marrow aspiration and trephine biopsy. An approach to a thorough study. Am J Clin Pathol 1978;70:753-759.
56. Wolff SN, Katzenstein AL, Phillips GL, Herzig GP. Aspiration does not influence interpretation of bone marrow biopsy cellularity. Am J Clin Pathol 1983;80:60-62.
57. Raich PC, Rogers 2nd JS. Bone marrow aspiration and biopsy. W V Med J 1980;76:1-4.
58. Shively JA. Examination of the bone marrow. In: Kopeka JA, editor. Laboratory hematology. New York: Churchill Livingstone; 1984, p 1023-1050.
59. Hyun BH, Gulati GL, Ashton JK. Bone marrow examination: techniques and interpretation. Hematol Oncol Clin North Amer 1988;2:513-523.
60. Hodges A, Koury MJ. Needle aspiration and biopsy in the diagnosis and monitoring of bone marrow diseases. Clin Lab Sci 1996;9:349-353.
61. Bashawri LA, Bone marrow examination. Indications and diagnostic value. Saudi Med J 2002;23:191-196.
62. Hernandez-Garcia MT, Hernandez-Nieto L, Perez-Gonzalez E, Brito-Barroso ML. Bone marrow trephine biopsy: anterior superior iliac spine versus posterior superior iliac spine. Clin Lab Haematol 1993;15:15-19.
63. Jacobs P. Bone-marrow aspiration and trephine biopsy. Br Med J 1980;281:944.
64. Milligan DW, Howard MR, Judd A. Premedication with lorazepam before bone marrow biopsy. J Clin Pathol 1987;40:696-698.
65. Cozzutto C, De Bernardi B, Comelli A, Guarino M. Bone marrow biopsy in children: a study of 111 patients. Med Pediatr Oncol 1979;6:57-64.
66. Jay SM, Elliott CH, Ozolins M, Olson RA, Pruitt SD. Behavioral management of children's distress during painful medical procedures. Behav Res Ther 1985;23:513-520.
67. Schechter NL, Weisman SJ, Rosenblum M, Bernstein B, Conard PL. The use of oral transmucosal fentanyl citrate for painful procedures in children. Pediatrics 1995;95:335-339.
68. Zafar T, Javaid S, Saleem M, Malik ZA, Khattak MF. Ketamine for bone marrow aspiration and trephine biopsy in children. J Pak Med Assoc 1997;47:304-305.
69. Klein ER. Premedicating children for painful invasive procedures. J Pediatr Oncol Nurs 1992;9:170-179.
70. Weisberger AS. The significance of 'dry tap' bone marrow aspirations. Am J Med 1955;229:63-68.
71. Navone R, Colombano MT. Histopathological trephine biopsy findings in cases of 'dry tap' bone marrow aspirations. Appl Pathol 1984;2:264-271.
72. Humphries JE. Dry tap bone emarrow aspiration: clinical significance. Am J Hematol 1990;35:247-250.
73. Reid MM. Dry tap marrow aspiration. Am J Hematol 1991;37:218-219.
74. Normann T, Stavem P. Bone marrow biopsy. A necessary procedure when no marrow is obtained by aspiration. Nord Med 1970;83:169-171.
75. Engeset A, Nesheim A, Sokolowski J. Incidence of 'dry tap' on bone marrow aspirations in lymphomas and carcinomas. Diagnostic value of the small material in the needle. Scand J Haematol 1979;22:417-422.
76. Mark T, Levin A. Histologic examination of the bone marrow: aspiration or trephine? South Med J 1981;74:1447-1450.
77. Sen R, Singh S, Singh HP, et al. Demonstration of acid-fast bacilli in buffy coat and bone marrow smear - a diagnostic tool in pulmonary tuberculosis. J Indian Med Assoc 1996;94:379-380, 390.
78. Sola MC, Rimsza LM, Christensen RD. A bone marrow biopsy technique suitable for use in neonates. Br J Haematol 1999;107:458-460.
79. Liao KT. The superiority of histologic sections of aspirated bone marrow in malignant lymphomas. A review of 1,124 examinations. Cancer 1971;27:618-628.
80. Cetto GL, Iannucci A, Perini A, et al. Bone marrow evaluation: the relative merits of particle sections and smear preparations. Appl Pathol 1983;1:181-193.
81. James LP, Stass SA, Schumacher HR. Value of imprint preparations of bone marrow biopsies in hematologic diagnosis. Cancer 1980;46:173-177.
82. Pasquale D, Chikkappa G. Comparative evaluation of bone marrow aspirate particle smears, biopsy imprints, and biopsy sections. Am J Hematol 1986;22:381-389.
83. Sabharwal BD, Malhotra V, Aruna S, Grewal R. Comparative evaluation of bone marrow aspirate particle smears, imprints and biopsy sections. J Postgrad Med 1990;36:194-198.
84. Kjurkchiev G, Valkov I. Role of touch imprint and core biopsy for detection of tumor metastases in bone marrow. Diagn Cytopathol 1998;18:323-324.
85. Aboul-Nasr R, Estey EH, Kantarjian HM, et al. Comparison of touch imprints with aspirate smears for evaluating bone marrow specimens. Am J Clin Pathol 1999;111:753-758.
86. Bouton SM. Touch imprints and aspirate smears for evaluating bone marrow specimens. Am J Clin Pathol 2001;15:160-161.
87. Islam A. A new bone marrow biopsy needle with core securing device. J Clin Pathol 1982;35:359-364.
88. Bearden JD, Ratkin GA, Coltman CA. Comparison of the diagnostic value of bone marrow biopsy and bone marrow aspiration in neoplastic disease. J Clin Pathol 1974;27:738-740
89. Block M. Bone marrow examination: aspiration or core biopsy, smear or section, hematoxylin-eosin or Romanowsky stain-which combination? Arch Pathol Lab Med 1976;100:454-456.
90. Dee JW, Valdivieso M, Drewinko B. Comparison of the efficacies of closed trephine needle biopsy, aspirated paraffin-embedded clot section, and smear preparation in the diagnosis of bone-marrow involvement by lymphoma. Am J Clin Pathol 1976;65:183-194.
91. Singh G, Krause JR, Breitfeld V. Bone marrow examination for metastatic tumor: aspirate and biopsy. Cancer 1977;40:2317-2321.
92. Savage RA, Hoffman GC, Shaker K. Diagnostic problems involved in detection of metastatic neoplasms by bone-marrow aspirate compared with needle biopsy. Am J Clin Pathol 1978;70:623-627.
93. Islam A, Henderson ES. Value of long-core biopsy in the detection of discrete bone marrow lesions. Histopathology 1988;12:641-648.
94. Bishop PW, McNally K, Harris M. Audit of bone marrow trephines. J Clin Pathol 1992;45:1105-1108.
95. Reid MM, Roald B. Adequacy of bone marrow trephine biopsy specimens in children. J Clin Pathol 1996;49:226-229.
96. Reid MM, Roald B. Central review of bone marrow biopsy specimens from patients with neuroblastoma. J Clin Pathol 1996;49:691-692.
97. Reid MM, Roald B. Deterioration in performance in obtaining bone marrow trephine biopsy cores from children. European Neuroblastoma Study Group. J Clin Pathol 1999;52: 851-852.
98. Jacobs P. Core length in bone-marrow biopsy. Lancet 1979;1:1405-1406.
99. Franklin IM, Pritchard J. Detection of bone marrow invasion by neuroblastoma is improved by sampling at two sites with both aspirates and trephine biopsies. J Clin Pathol 1983;36: 1215-1218.
100. Brunning RD, Bloomfield CD, McKenna RW, Peterson L. Bilateral trephine bone marrow biopsies in lymphoma and other neoplastic disease. Ann Intern Med 1975;82:365-366.
101. Menon NC, Buchanan JG. Bilateral trephine bone marrow biopsies in Hodgkin's and non-Hodgkin's lymphoma. Pathology 1979;11:53-57.
102. Ebie N, Loew JM, Gregory SA. Bilateral trephine bone marrow biopsy for staging non-Hodgkin's lymphoma-a second look. Hematol Pathol 1989;3:29-33.
103. Haddy TB, Parker RI, Magrath IT. Bone marrow involvement in young patients with non-Hodgkin's lymphoma: the importance of multiple bone marrow samples for accurate staging. Med Pediatr Oncol 1989;17:418-423.
104. Juneja SK, Wolf MM, Cooper IA. Value of bilateral bone marrow biopsy specimens in non-Hodgkin's lymphoma. J Clin Pathol 1990;43:630-632.
105. Varma N, Dash S, Sarode R, Marwaha N. Relative efficacy of bone marrow trephine biopsy sections as compared to trephine imprints and aspiration smears in routine hematological practice. Indian J Pathol Microbiol 1993;36:215-226.
106. Almeida J, Garcia-Marcos MA, Vallejo C, et al. [Results of a series of 104 consecutive bilateral bone marrow biopsy specimens in lymphoproliferative disorders]. Sangre (Barc) 1995;40:365-368.
107. Luoni M, Declich P, De Paoli Ap, et al. Bone marrow biopsy for the staging of non-Hodgkin's lymphoma: bilateral or unilateral trephine biopsy? Tumori 1995;81:410-413.
108. Manegold C, Krempien B, Bulzebruck H, Drings P. Value of bilateral iliac crest needle biopsy for pretherapeutic tumor staging of bronchogenic carcinomas. Oncology 1989;46:226-229.
109. Hirsch FR, Hansen HH, Hainau B. Bilateral bone-marrow examinations in small-cell anaplastic carcinoma of the lung. Acta Pathol Microbiol Scand [A] 1979;87:59-62.
110. Kamby C, Vejborg I, Daugaard S, et al. Clinical and radiologic characteristics of bone metastases in breast cancer. Cancer 1987;60:2524-2531.
111. Wang J, Weiss LM, Chang KL, et al. Diagnostic utility of bilateral bone marrow examination: significance of morphologic and ancillary technique study in malignancy. Cancer 2002;94:1522-1531.
112. Bakir F. Fatal sternal puncture. Report of a case. Dis Chest 1963;44:435.
113. Garnier H, Reynier J, Dimopoulog F. A propos des accidents de la ponction sternale. Ann Chir 1964;18:308.
114. Gerdin B. Sternal puncture with a fatal outcome. Lakartidningen 1980;77:3384-3386.
115. Puschel K, Mattern R, Mittmeyer HJ, Schneider V. Errors and hazards: fatalities through sternal puncture. Dtsch Med Wochenschr 1985;110:161-1613.
116. Pascali VL, Lazzaro P, Fiori A, Is sternal bone marrow needle biopsy still a hazardous technique? Report of three further fatal cases. Am J Forensic Med Pathol 1987;8:42-44.
117. Eastlund DT. Sternal-manubrial separation as a complication of marrow aspiration in a patient with protein-calorie malnutrition and osteoporosis. Acta Haemat 1990;83:42-44.
118. Yoell JH. Bone marrow embolism to lung following sternal puncture. Arch Pathol Lab Med 1959;67:373.
119. Fine NL, Reich EJ, Weinsaft P. Growth of sternal tumor mass following bone marrow aspiration. MNY State J Med 1967;67:2866.
120. Ben-Chetrit E, Flusser D, Assaf Y. Severe bleeding complicating percutaneous bone marrow biopsy. Arch Intern Med 1984;144:2284.
121. Steinke B. Complications after bone marrow biopsy. Dtsch Med Wochenschr 1992;117:1003-1004.
122. Gupta S, Meyers ML, Trambert J, Billett HH. Massive intra-abdominal bleeding complicating bone marrow aspiration and biopsy in multiple myeloma. Postgrad Med J 1992;68:770.
123. Fisher WB. Hazard in bone-marrow biopsy. N Engl J Med 1971;285:804.
124. McNutt DR, Fudenberg HH. Bone-marrow biopsy and osteoporosis. N Engl J Med 1972;286:46.
125. Pedersen LM, Jarner D, Winge J. Bone-marrow biopsy of the iliac bone followed by severe retroperitoneal hemorrhage. Eur J Haematol 1993;51:52.