Application of substituted 2-(trimethylsilyl)ethyl esters to suppress diketopiperazine formation

Tetrahedron Letters

Volumn 45, Issue 18, 2004, Pages 3585-3588

  Borsuk, Katarzyna ^a   Van Delft, Floris L ^a   Eggen, Ivo F ^b   Ten Kortenaar, Paul B W ^b   Petersen, Annet ^b   Rutjes, Floris P J T ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b Diosynth BV   (Netherlands)

Author keywords

Diketopiperazine formation; Protecting groups; Solution phase peptide synthesis

Indexed keywords

DIPEPTIDE; ESTER DERIVATIVE; METHYL GROUP; PEPTIDE; PIPERAZINEDIONE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DEPROTECTION REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PEPTIDE SYNTHESIS; REACTION ANALYSIS; REDUCTION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

EID: 1842787725     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.03.054     Document Type: Article

References (12)

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12. 3 (2×11 mL) and 30% aqueous NaCl (3×11 mL).