Is calcium oxalate nucleation in postprandial urine of males with idiopathic recurrent calcium urolithiasis related to calcium phosphate nucleation and the intensity of stone formation? Studies allowing insight into a posibble role of urinary free citrate and protein

Clinical Chemistry and Laboratory Medicine

Volumn 42, Issue 3, 2004, Pages 283-293

  Schwille, Paul O ^a,b   Shcmiedl, Angelika ^a   Manoharan, Mahimaidos ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b NONE   (Germany)

Author keywords

Calcium oxalate and calcium phosphate; Crystal morphology; Idiopathic calcium urolothiasis; Nucleation in whole urine; Proteinuria; Urinary free citrate

Indexed keywords

ALBUMIN; CALCIUM; CALCIUM OXALATE; CALCIUM PHOSPHATE; CALCIUM PHOSPHATE DIBASIC; CITRIC ACID; HYDROXYAPATITE; OXALIC ACID; PHOSPHATE; POTASSIUM;

ADULT; AGED; ARTICLE; CALCIUM STONE; CALCIUM URINE LEVEL; CHEMICAL ANALYSIS; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYSTALLIZATION; DIET RESTRICTION; ELECTRON MICROSCOPY; FEASIBILITY STUDY; GENDER; HUMAN; HYPEROXALURIA; IDIOPATHIC DISEASE; IN VITRO STUDY; LIQUID; MAJOR CLINICAL STUDY; MALE; MEAL; METABOLISM; PARTICLE SIZE; PHASE TRANSITION; POSTPRANDIAL STATE; PRECIPITATION; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA; RECURRENT DISEASE; SOLID; STATISTICAL SIGNIFICANCE; STONE FORMATION; URINE LEVEL; URINE PH; URINE VOLUME; UROLITHIASIS;

ADULT; AGED; CALCIUM; CALCIUM CHLORIDE; CALCIUM OXALATE; CALCIUM PHOSPHATES; CITRIC ACID; CREATINE; CRYSTALLIZATION; CRYSTALLOGRAPHY; DATA INTERPRETATION, STATISTICAL; ELECTRON PROBE MICROANALYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MIDDLE AGED; OXALATES; PHOSPHATES; POSTPRANDIAL PERIOD; POTASSIUM; PROTEINS; PROTEINURIA; REGRESSION ANALYSIS; URINARY CALCULI; URINE;

EID: 1842787599     PISSN: 14346621     EISSN: None     Source Type: Journal    
DOI: 10.1515/CCLM.2004.052     Document Type: Article

References (38)

1. Tiselius HG, Larsson L. Calcium phosphate: an important crystal phase in patients with recurrent calcium stone formation? Urol Res 1993;21:175-80.
2. Larsson L, Sörbo B, Tiselius HG, Ohman S. A method for quantitative wet-chemical analysis of urinary calculi. Clin Chim Acta 1984;140:9-14.
3. Lonsdale K. Human stones. Science 1968;159:1199-207.
4. Herring LC. Observations on the analysis of ten thousand urinary calculi. J Urol 1962;88:545-62.
5. Doyle IR, Ryall RL, Marshall VR. The inclusion of proteins into calcium oxalate crystals precipitated from urine. A highly selective phenomenon. Clin Chem 1991;37:1589-94.
6. Ryall RL, Stapleton AMF. Urinary macromolecules in calcium oxalate stone and crystal matrix: good, bad or indifferent. In: Khan SR, editor. Calcium oxalate in biological systems. Boca Raton: CRC Press, 1995:265-90.
7. Fleisch H. Mechanisms of stone formation: role of promoters and inhibitors. Scand J Urol Nephrol Suppl 1980;53:53-9.
8. Nicar MJ, Hill K, Pak CYC. Inhibition of citrate of spontaneous precipitation of calcium oxalate in vitro. J Bone Min Res 1987;2:215-20.
9. Fan J, Schwille PO, Schmiedl A, Fink E, Manoharan M. Calcium oxalate crystallization in undiluted postprandial urine of healthy male volunteers as influenced by citrate. Drug Res 2001;51:848-57.
10. Schwille PO, Schmiedl A, Herrmann U, Fan J, Gottlieb D, Manoharan M, Wipplinger J. Magnesium, citrate, magnesium citrate and magnesium-alkali citrate as modulators of calcium oxalate crystallization in urine: observations in patients with recurrent idiopathic calcium urolithiasis. Urol Res 1999;27:117-26.
11. Cerini C, Geider S, Dussol B, Hennequin C, Daudon M, Veesler S, et al. Nucleation of calcium oxalate crystals by albumin: involvement in the prevention of stone formation. Kidney Int 1999;55:1776-86.
12. Kok DJ. Clinical implications of physicochemistry of stone formation. Endocrinol Metab Clin N Am 2002;31:855-67.
13. Schwille PO, Schmiedl A, Rümenapf G. Disorders of calcium metabolism - appraisal and management. In: Whitfield H, Hendry B, Kirby R, Duckett J, editors. Textbook of genito-urinary surgery. Oxford: Blackwell Scientific Publications, 1998:771-98.
14. Smith LH, Werness PG, Erickson SD, Phillips SF. Postprandial response to a normal diet in patients with idiopathic calcium urolithiasis. In: Ryall R, Brockis JG, Marshall V, Finlayson B, editors. Urinary stone. Melbourne, Edinburgh, London, New York: Churchill Livingstone, 1984:47-56.
15. Herrmann U, Schwille PO, Kuch P. Crystalluria determined by polarization microscopy. Technique and results in healthy control subjects and patients with idiopathic calcium urolithiasis classified in accordance with calciuria. Urol Res 1991;19:151-8.
16. Fan J, Schwille PO, Manoharan M, Gottlieb D, Schmiedl A. Calcium oxalate nucleation, growth and aggregation in undiluted urine of healthy controls and patients with idiopathic recurrent calcium urolithiasis evaluated by a one-time small-volume test procedure - effects of alkali citrate. Clin Lab 1995;41:139-44.
17. Schmiedl, A Schwille PO. Tolerables Oxalate im Urin. Grundlagen, Verbesserung der Meßmethode und Bewertung bei idiopathischer Calcium-Urolithiasis. Klin Lab 1994;40:741-7.
18. Curreri PA, Onoda G, Finlayson B. A comparative appraisal of adsorption of citrate on whewellite seed crystals. J Cryst Growth 1981;53:209-14.
19. Manoharan M, Schwille PO. Oxypurines, protein, glucose and the functional state of blood vasculature are markers of renal calcium stone-forming processes? Observations in men with idiopathic recurrent calcium urolithiasis. Clin Chem Lab Med 2002;40:266-77.
20. Schmiedl A, Schwille PO. Magnesium status in idiopathic calcium urolithiasis - an orientational study in younger males. Eur J Clin Chem Clin Biochem 1996;34:393-400.
21. Schmiedl A, Schwille PO. Is magnesium a marker of disordered mineral metabolism in males with idiopathic calcium urolithiasis? Observations focussing on fasting magnesiuria and magnesiemia, proteins and other substances in urine and plasma. Magnes Res 2003;16:192-205.
22. Marshall RW, Robertson WG. Nomograms for the estimation of the saturation of urine with calcium oxalate, calcium phosphate, magnesium ammonium phosphate, uric acid, sodium acid urate, ammonium acid urate, and cystine. Clin Chim Acta 1976;72:253-60.
23. Werness PG, Brown CM, Smith LH. EQUIL-2: a BASIC computer programme for the calculation of urinary supersaturation. J Urol 1985;134:1242-4.
24. Tiselius HG. Is precipitation of calcium phosphate an important factor for the development of calcium oxalate stones in the urinary tract? Front Biosci 2003;8:326-32.
25. Asplin JR, Parks JH, Chen MS, Lieske JC, Toback FG, Pillay SN, et al. Reduced crystallization inhibition by urine for men with nephrolithiasis. Kidney Int 1999;56:1505-16.
26. Cheng PT, Pritzker KPH. Solution Ca/P ratio affects calcium phosphate crystal phases. Calcif Tissue Int 1983;35:596-601.
27. Höhling HJ, Arnold S, Barckhaus RH, Plate U, Wiesmann HP. Structural relationship between the primary crystal formations and the matrix macromolecules in different hard tissues. Discussion of a general principle. Conn Tissue Res 1995;33:171-8.
28. Seaborn CD, Nielsen FH. Effects of germanium and silicon on bone mineralization. Biol Trace Elem Res 1994;42:151-64.
29. Kajander EO, Ciftioglu N, Aho K, Garcia-Cuerpo E. Characteristics of nanobacteria and their possible role in stone formation. Urol Res 2003;31:47-54.
30. Wiesmann HP, Plate U, Zierold K, Höhling HJ. Potassium is involved in apatite biomineralization. J Dent Res 1998;77:1654-7.
31. Silva IV, Morales MM, Lopes AG. CI C5 chloride channel and kidney stones: what is the link? Braz J Med Biol Res 2001;34:315-21.
32. Baumann JM, Ackermann D, Affolter B. The influence of hydroxyapatite and pyrophosphate on the formation product of calcium oxalate at different pHs. Urol Res 1989;17:153-5.
33. Achilles W, Jöckel U, Schaper A, Burk M, Riedmüller H. In vitro formation of "urinary stones": generation of spherulites of calcium phosphate in gel and overgrowth with calcium oxalate using a new flow model of crystallization. Scann Microsc 1995;9:577-86.
34. Osther PJ, Bollerslev J, Hansen AB, Engel K, Kildeberg P. Pathophysiology of incomplete renal tubular acidosis in recurrent renal calcium stone formers: evidence of disturbed calcium, bone and citrate metabolism. Urol Res 1993;21:169-73.
35. Herrmann U, Schwille PO. Crystalluria in idiopathic calcium urolithiasis. Dependence on stone composition. Urol Res 1992;20:157-64.
36. Schwille PO, Schmiedl A, Manoharan M, Wipplinger J. Is there a role for uric acid in an animal model of calcium phosphate nephrocalcinosis and calcium phosphate crystallization in urine of patients with idiopathic calcium urolithiasis? An orientational study. J Endourol 1999;13:637-45.
37. Greischar A, Nakagawa Y, Coe FL. Influence of urine pH on metastability for calcium phosphate. J Urol 2003;169:867-70.
38. Kok DJ, Papapoulos SE, Bijvoet OLM. Low inhibition of crystal agglomeration and citrate excretion in recurrent calcium oxalate stone formers. Contr Nephrol 1987;58:73-7.