Leiden mutation, bed rest and infection: Simultaneous triggers for maternal deep-vein thrombosis and neonatal intracranial hemorrhage?

Fetal Diagnosis and Therapy

Volumn 19, Issue 3, 2004, Pages 275-277

  Sikovanyecz, János ^a   Orvos, Hajnalka ^a   Pál, Attila ^a   Katona, Márta ^a   Endreffy, Emõke ^a   Horváth, Emese ^a   Szabó, János ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Leiden mutation; Neonatal intracranial hemorrhage; Vein thrombosis

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; ANTICONVULSIVE AGENT; BETA 2 MIMETIC; BLOOD CLOTTING FACTOR 5 LEIDEN; DEXAMETHASONE; HEPARIN; HEPARIN CALCIUM; SULBACTAM; UNCLASSIFIED DRUG; UTERUS SPASMOLYTIC AGENT;

ADULT; ALLELE; ARTICLE; BACTERIAL INFECTION; BED REST; BRAIN HEMORRHAGE; CASE REPORT; CLINICAL FEATURE; DEEP VEIN THROMBOSIS; DELIVERY; DIAGNOSTIC IMAGING; DISEASE ACTIVITY; DISEASE COURSE; ENTEROCOCCUS FAECALIS; FEMALE; FEMORAL VEIN; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HYDROCEPHALUS; LABORATORY TEST; MALE; MICROBIOLOGICAL EXAMINATION; MOTHER; MUTATION; NEUROLOGIC EXAMINATION; NEWBORN; PHYSICAL EXAMINATION; PREMATURE LABOR; PREMATURITY; PRIORITY JOURNAL; REOPERATION; RESPIRATORY DISTRESS SYNDROME; RISK; SEIZURE; TOCOLYSIS;

ADULT; BACTERIAL INFECTIONS; BED REST; CEREBRAL HEMORRHAGE; FACTOR V; FEMALE; FEMORAL VEIN; GENETIC PREDISPOSITION TO DISEASE; HOMOZYGOTE; HUMANS; INFANT, NEWBORN; OBSTETRIC LABOR, PREMATURE; POINT MUTATION; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PREGNANCY COMPLICATIONS, INFECTIOUS; TOCOLYTIC AGENTS; VENOUS THROMBOSIS;

EID: 1842786849     PISSN: 10153837     EISSN: None     Source Type: Journal    
DOI: 10.1159/000076711     Document Type: Article

References (16)

1. McColl MD, Walker LD, Greer IA: The role of inherited thrombophilia in venous thromboembolism associated with pregnancy. Br J Obstet Gynaecol 1999;106:756-766.
2. Dizon-Townson DS, Nelson LM, Jang H, Varner MW, Ward K: The incidence of factor V Leiden mutation in an obstetric population and its relationship to deep vein thrombosis. Am J Obstet Gynecol 1997;176:883-886.
3. Bauer KA: Management of patients with hereditary defects predisposing to thrombosis including pregnant women. Thromb Haem 1995;74:94-100.
4. Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, Fait G, Lessing J: Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999;340:9-13.
5. Rai RS, Regan L, Chitolie A, Donald JG, Cohen H: Placental thrombosis and second trimester miscarriage in association with activated protein C resistance. Br J Obst Gynaecol 1996;103:842-844.
6. Grandone E, Margaglione M, Colaizzo D, D'Andrea G, Cappucci G, Brancaccio V, Di Minno G: Genetic susceptibility to pregnancy-related venous thromboembolism: Roles of factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations. Am J Obstet Gynecol 1998;179:1324-1328.
7. Hellgren M, Svensson PJ, Dahlbäck B: Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and oral contraceptives. Am J Obstet Gynecol 1995;173:210-213.
8. Pauer HU, Neesen J, Schlosser M, Hinney B, Rauskolb R: Homozygous factor V Leiden mutation in woman with multiple adverse pregnancy outcomes. Arch Gynecol Obstet 2000;264:164-165.
9. Melegh B, Stankovics J, Kis A, Nagy Á, Storcz J, Losonczy H, Méhes K: Increased prevalence of factor V Leiden mutation in neonatal intracranial haemorrhage. Eur J Pediatr 1998;157:261.
10. Varelas PN, Sleight BJ, Rinder HM, Sze G, Ment LR: Stroke in a neonate heterozygous for factor V Leiden. Pediatr Neurol 1998 Mar; 18:262-264.
11. Hagstrom JN, Walter J, Bluebond-Langner R, Amatniek JC, Manno Cs, High KA: Prevalence of the factor V Leiden in children and neonates with thromboembolic disease. J Pediatr 1998;133:777-781.
12. Broxterman KJ, Mathew P, Chicoine L: Left brachial artery thrombus, left axillary vein thrombus, and stroke in a neonate with factor V Leiden mutation. J Pediatr Hematol Oncol 2000;22:472-475.
13. Erhardt E, Stankovics J, Molnár D, Adamovich K, Melegh B: High prevalence of factor V Leiden mutation in mothers of premature neonates. Biol Neonate 2000;78:145-146.
14. Kenyon S, Boulvain M, Neilson J: Antibiotics for preterm premature rupture of membranes (Cochrane Review). Cochrane Database Syst Rev 2001;4:CD001058.
15. Kovacevich GJ, Gaich SA, Lavin JP, Hopkins MP, Crane SS, Stewart J, Nelson D, Lavin LM: The prevalence of thromboembolic events among women with extended bed rest prescribed as part of the treatment for premature labour or preterm premature rupture of membrane. Am J Obstet Gynecol 2000;182:1089-1092.
16. Schneider H, Malek A: Lack of permeability of the human placenta for erythropoietin. J Perinat Med 1995;23:71-76.