Selection and genetic analysis of pseudohyphae defective mutants with attenuated virulence in Candida lusitaniae

Journal de Mycologie Medicale

Volumn 14, Issue 1, 2004, Pages 3-11

  Goumar, A ^a   Brulfert, A ^a   Martin, C ^a   Villard, J ^a   Noel T ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Adhesion; Candida lusitaniae; Pseudohyphal growth; Virulence

Indexed keywords

ANIMAL MODEL; ARTICLE; CANDIDA; CANDIDA LUSITANIAE; CANDIDIASIS; FUNGAL VIRULENCE; FUNGUS GROWTH; FUNGUS MUTANT; GENETIC ANALYSIS; MALE; MOUSE; NONHUMAN; NUDE MOUSE; OPPORTUNISTIC INFECTION;

ANIMALIA; CANDIDA; CLAVISPORA LUSITANIAE; FUNGI; MUS MUSCULUS;

EID: 1842763049     PISSN: 11565233     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Arendrup M, Horn T, Frimodt-Moller N. In vivo pathogenicity of eight medically relevant Candida species in an animal model. Infection 2002;30:286-91.
2. Bendel CM, Kinneberg KM, Jechorek RP, et al. Systemic infection following intravenous inoculation of mice with Candida albicans int1 mutant strains. Mol Genet Metab 1999;67:343-51.
3. Biasoli MS, Tosello ME, Magaro HM. Adherence of Candida strains isolated from the human gastrointestinal tract. Mycoses 2002;45:465-9.
4. Borg-von Zepelin M, Wagner T. Fluorescence assay for the detection of adherent Candida yeasts to target cells in microtest plates. Mycoses 1995;38:339-47.
5. Burke DD, Dawson D, Stearns T (eds), Methods in Yeast Genetics: a Cold Spring Harbor Laboratory Course Manual, 2000 edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2000.
6. Calderone RA, Fonzi WA. Virulence factors of Candida albicans. Trends Microbiol 2001;9:327-35.
7. Csank C, Haynes K. Candida glabrata displays pseudohyphal growth. FEMS Microbiol Lett 2000;189:115-20.
8. Ernst JF. Transcription factors in Candida albicans - environmental control of morphogenesis. Microbiology 2000;146:1763-74.
9. François F, Noël T, Pépin R, et al. Alternative identification test relying upon sexual reproductive abilities of Candida lusitaniae strains isolated from hospitalized patients. J Clin Microbiol 2001;39:3906-14.
10. Gancedo JM. Control of pseudohyphae formation in Saccharomyces cerevisiae. FEMS Microbiol Rev 2001;25:107-23.
11. Gimeno CJ, Ljungdahl PO, Styles CA, Fink GR. Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 1992;68:1077-90.
12. Gow NAR, Brown AJP, Odds FC. Fungal morphogenesis and host invasion. Curr Opin Microbiol 2002;5:366-71.
13. Hazen KC. New and emerging yeast pathogens. Clin Microbiol Rev 1995;8:462-78.
14. Hotchkiss RD. A micro-chemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. Arch Biochem Biophys 1948;16:131-1.
15. Karyotakis NC, Anaissie EJ. Efficacy of continuous flucytosine infusion against Candida lusitaniae in experimental hematogenous murine candidiasis. Antimicrob Agents Chemother 1996;40:2907-8.
16. Krcmery V Jr, Mateicka F, Grausova S, Kunova A, Hanzen J. Invasive infections due to Clavispora lusitaniae. FEMS Immunol Med Microbiol 1999;23:75-8.
17. Lambrechts MG, Bauer FF, Marmur J, Pretorius IS. Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast. Proc Natl Acad Sci USA 1996;93:8419-24.
18. Leberer E, Harcus D, Broadbent ID, et al. Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Proc Natl Acad Sci USA 1996;93:13217-22.
19. Leberer E, Ziegelbauer K, Schmidt A, et al. Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4p. Curr Biol 1997;7:539-46.
20. Liu H, Styles CA, Fink GR. Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science 1993;262:1741-4.
21. Lo HJ, Kohler JR, DiDomenico B, et al. Nonfilamentous C. albicans mutants are avirulent. Cell 1997;90:939-49.
22. Lorenz MC, Cutler NS, Heitman J. Characterization of alcohol-induced filamentous growth in Saccharomyces cerevisiae. Mol Biol Cell 2000;11:183-99.
23. Lorenz MC, Heitman J. Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains. Genetics 1998;150:1443-57.
24. Lorenz MC, Heitman J. Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog. Embo J 1997;16:7008-18.
25. Madhani HD, Fink GR. The control of filamentous differentiation and virulence in fungi. Trends Cell Biol 1998;8:348-53.
26. Merz WG. Candida lusitaniae: frequency of recovery, colonization, infection, and amphotericin B resistance. J Clin Microbiol 1984;20:1194-5.
27. Noël T, François F, Paumard P, et al. Flucytosine-fluconazole cross-resistance in purine-cytosine permease-deficient Candida lusitaniae clinical isolates: indirect evidence of a fluconazole uptake transporter. Antimicrob Agents Chemother 2003;47:1275-84.
28. Samaranayake YH, Wu PC, Samaranayake LP, So M, Yuen KY. Adhesion and colonisation of Candida krusei on host surfaces. J Med Microbiol 1994;41:250-8.
29. Sipiczki M, Takeo K, Yamaguchi M, Yoshida S, Miklos I. Environmentally controlled dimorphic cycle in a fission yeast. Microbiology 1998;144:1319-30.
30. Suzuki T, Imanishi Y, Iwaguchi S, Kamihara T. Depolarized cell growth precedes filamentation during the process of ethanol-induced pseudohyphal formation in the yeast Candida tropicalis. Microbiology 1998;144:403-10.
31. Young LY, Lorenz MC, Heitman J. A STE12 homolog is required for mating but dispensable for filamentation in Candida lusitaniae. Genetics 2000;155:17-29.