A rare combination consisting of aldosterone-producing adenoma and adrenal myelolipoma in a patient with heterozygosity for retinoblastoma (RB) gene

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 5, Issue 1, 2004, Pages 45-48

  Caliumi, Chiara ^a   De Toma, Giorgio ^a   Bossini, Alfredo ^a   Cianci, Rosario ^a   Bosman, Cesare ^a   Genuardi, Maurizio ^b   Cerci, Sabrina ^a   Letizia, Claudio ^a,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c POLICLINICO UMBERTO I   (Italy)

Author keywords

Adrenal myelolipoma; Aldosterone producing adenoma; Multiple lipomas; Retinoblastoma gene (RB)

Indexed keywords

ALDOSTERONE; AMLODIPINE; ANTIHYPERTENSIVE AGENT; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DEXAMETHASONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENALAPRIL; HYDROCHLOROTHIAZIDE; NIFEDIPINE; NISOLDIPINE;

ADRENAL CORTEX ADENOMA; ADRENALECTOMY; ADULT; ANAMNESIS; ARTICLE; CASE REPORT; CLINICAL FEATURE; COMORBIDITY; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HETEROZYGOSITY; HORMONE DETERMINATION; HUMAN; HYPERTENSION; HYPOPHYSIS ADENOMA; LABORATORY TEST; LAPAROSCOPIC SURGERY; LIPOMA; MALE; MULTIPLE CANCER; MYELOLIPOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PRIMARY HYPERALDOSTERONISM; THYROID ADENOMA; THYROIDECTOMY; TUMOR SUPPRESSOR GENE;

EID: 1842737185     PISSN: 14703203     EISSN: None     Source Type: Journal    
DOI: 10.3317/jraas.2004.008     Document Type: Article

References (44)

1. Conn JW. Primary aldosteronism, a new clinical syndrome. J Lab Clin Med 1955;45:6-20.
2. Ganguly A. Primary aldosteronism. N Engl J Med 1998; 339:1828-34.
3. Gomez-Sanchez CE. Primary aldosteronism and its variants. Cardiovasc Res 1998;37:8-13.
4. Lim PO, Young WF, MacDonald TM. A review of the medical treatment of primary aldosteronism. J Hypertens 2001;19:353-61.
5. Blumenfeld JD, Vaughan ED Jr. Diagnosis and treatment of primary aldosteronism. World J Urol 1999;17:15-21.
6. Stowasser M, Gordon RD, Rutherford JC, Nikwan NZ, Daunt N, Slater GJ. Diagnosis and management of primary aldosteronism. JRAAS 2001;2:156-69.
7. Abe H, Kubota K, NoieT, Rimura W, Makuuki M. A rare combination consisting of primary aldosteronism and glucagonoma. Am J Gastroenterol 1999;94:1397-401.
8. Miyazawa K, Kigish T, Nakamo S et al. Hypertension due to coexisting pheochromocytoma and aldosterone-producing adrenal cortical adenoma. Am J Nephrol 1998;18:547-50.
9. Herd GW. A case of primary hyperparathyroidism, primary hyperaldosteronism and Cushings disease. Acta Endocrinol 1984;107:371-4.
10. Fertig A, Webley M, Lynm JA. Primary hyperparathyroidism in a patient with Conn's syndrome. Postgrad Med J 1980;56:45-7.
11. Beckers A, Abs R, Willems PJ et al. Aldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia type 1 (MEN1): Loss of heterozygosity for polymorphic chromosome 11 deoxyribonucleic acid markers including the MEN 1 locus. J Clin Endocrinol Metab 1992;75:564-70.
12. Noble MJ, Montague DK, Levin KS. Myelolipoma: an unusual surgical lesion of the adrenal gland. Cancer 1982;49: 952-8.
13. Cormio L, Ruutu M, Giardina C, Selvaggi FP. Combined adrenal adenoma and myelolipoma in a patient with Conn syndrome. Case report. Panminerva Med 1992;34:209-12.
14. Lazurova I, Sokol L,Trejbal D, Bober J, Zachar M, Pajtasova D. Aldosterone-producing adenoma associated with foci of myelolipoma. Wien Klin Wochensher 1998;110:379-81.
15. Genuardi M, Klutz M, Devriendt K, Caruso D, Sirpe M, Lohmann DR. Multiple lipomas linked to an RB1 gene mutation in large pedigree with low penetrance retinoblastoma. Eur J Hum Gen 2001;9:690-4.
16. Enzinger FM, Sharen WW. Benign lipomatous tumors. In: Enzinger FM Sharen WW (eds.). Soft tissue tumors, 3rd edn, Mosby, St Louis, 1995;pp 409-410.
17. Oliva A, Duarte B, Hammadeh R, Ghosh L, Baker RJ. Myelolipoma and endocrine dysfunction. Surgery 1998;103: 711-15.
18. Boronat M, Moreno A, Ramon Y et al. Subclinical Cushing's syndrome due to adrenal myelolipoma. Arch Pathol Lab Med 1997;121:735-7.
19. Jenkins PJ, Chew SL, Lowe DG, Reznek RH, Wass JA. Adrenocorticotropin independent unilateral macronodular adrenal hyperplasia occurring with myelolipoma: an unusual cause of Cushing's syndrome. Clin Endocrinol 1994;41:827-30.
20. Bennett BD, McKenna TJ, Hough AJ, Dean R, Page DL. Adrenal myelolipoma associated with Cushing's disease. Am J Clin Pathol 1980;73:443-7.
21. Vyberg M, Sestoft L. Combined adrenal myelolipoma and adenoma associated with Cushing's syndrome. Am J Clin Pathol 1986;86:541-5.
22. Han M, Burnett AL, Fishman EK, Marshall FF. The natural history and treatment of adrenal myelolipoma. J Urol 1997;157:1213-16.
23. Ukimura O, Inui E, Ochiai AM, Kojima M, Watanabe H. Combined adrenal myelolipoma and pheochromocytoma. J Urol 1995;154:1470.
24. Banik S, Hasleton PS, Lyon RL. An unusual variant of multiple endocrine neoplasia syndrome: a case report. Histopathology 1984;8:135-44.
25. Escuin F, Gomez P, Martinez I, Perez-Fontan M, Selgas R, Sanchez-Sicilia L. Angiomyelolipoma associated with bilateral adrenocortical hyperplasia and hypertension. J Urol 1985;133:655-7.
26. Boudreaux D, Waisman J, Skinner DG, Low R. Giant adrenal myelolipoma and testicular interstitial cell tumor in a man with congenital 21-hydroxylase deficiency Am J Surg Pathol 1979;3:109-23.
27. Hsu Li-Fern, Rajasoorya C.The elevated serum alkaline phosphatase - the chase that led to two endocrinopathies and one possible unifying diagnosis. Eur J Endocrinol 1999;140: 143-7.
28. Hofmockel G, Dammrich J, Manzanilla Garcia H, Frohmuller H. Myelolipoma of the adrenal gland associated with contralateral renal cell carcinoma: case report and review of the literature. J Urol 1995;153:129-32.
29. Sanders R, Bissada N, Curry N, Gordon B. Clinical spectrum of adrenal myelolipoma: analysis of 8 tumors in 7 patients. J Urol 1995;153:1791-3.
30. Casey LR, Cohen AJ, While AG, Detrich RB. Giant adrenal myelolipom: CT and MRI findings. Abdom Imaging 1994;19: 165-7.
31. Fujiwara R, Onishi T, Shimada A et al. Adrenal myelolipoma: comparison of diagnostic imaging and pathological findings. Intern Med 1993;32:166-70.
32. Sieber SC, Gelfman NA, Dandurand R, Braza F. Ectopic ACTH and adrenal myelolipoma. Conn Med 1989;53:7-10.
33. Dieckmann KP, Hamm B, Pickartz H, Jonas D, Bauer HW. Adrenal myelolipoma: clinical, radiologic and histologic features. Urology 1987;29:1-8.
34. Seyle H, Stone H. Hormonally induced transformation of adrenal intomyelolipoid tissue. Am J Pathol 1950;26:211-13.
35. Dluhy RG, Williams GH. Primary aldosteronism in a hypertensive acromegalic patient. J Clin Endocrinol Metab 1969;29:1319-24.
36. Hellman DE, Kartchner M, Komar N et al. Hyperaldosteronism, hyperparathyroidism, medullary sponge kidneys and hypertension. JAMA 1980;244:1351-4.
37. Ballard HS, Frame B, Hartstock RJ. Familial multiple endocrine adenoma-peptic ulcer complex. Medicine 1964;43: 481-516.
38. Strauch G, Vallonton MB, Touitou Y et al. The renin-angiotensin-aldosterone system in normotensive and hypertensive patients with acromegaly. N Engl J Med 1972;287:795-9.
39. Doumith R, De Gennes JL, Cabane JP, Zygelmann N. Pituitary prolactinoma, adrenal aldosterone producing adenomas, gastric schwannoma and colonic poliadenomas: a possible variant of multiple endocrine neoplasia (MEN) type 1. Acta Endocrinol 1982;100:189-95.
40. Stratakis CA. Clinical genetics of multiple endocrine neoplasias, Carney complex and related syndromes. J Endocrinol Invest 2001;24:370-83.
41. Huang HJS, Yee JK, Shew JI. et al. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 1988;242:1563-6.
42. Knudsen AG. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci Usa 1971;68:820-3.
43. Benedict WF, Xu HJ, Hu SX, Takahashi R. Role of the retinoblastoma gene in the initiation and progression of human cancer. J Clin Invest 1990;85:988-93.
44. Cryns VL, Alexander JM, Klibanski A, Arnold A. The retinoblastoma gene in human pituitary tumors. J Clin Endocrinol Metab 1993;77:644-6.