Mechanical and thermal anti-nociception in rats after systemic administration of verapamil

Neuroscience Letters

Volumn 360, Issue 1-2, 2004, Pages 57-60

  Todorovic, Slobodan M ^a   Pathirathna, Sriyani ^a   Meyenburg, Adam ^b   Jevtovic Todorovic, Vesna ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

L type Ca2+ channels; Nociception; Sensorimotor testing

Indexed keywords

CALCIUM CHANNEL L TYPE; VERAPAMIL;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; EXPERIMENTAL RAT; FEMALE; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; SIGNAL TRANSDUCTION; THERMAL ANALYSIS;

ANALGESICS; ANIMALS; CALCIUM CHANNELS, L-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEAT; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; TOUCH; VERAPAMIL;

EID: 1842713310     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.02.049     Document Type: Article

References (20)

1. Cervero F., Laird J.M.A. Role of ion channels in mechanisms controlling gastrointestinal pain pathways. Curr. Opin. Pharmacol. 3:2003;608-612.
2. Doran A.R., Narang P.K., Meigs C.Y., Wolkowitz O.M., Roy A., Brier A., Pickar D. Verapamil concentrations in cerebrospinal fluid after oral administration. N. Engl. J. Med. 312:1985;1261-1262.
3. Gruner W., Silva L.R. ω-Conotoxin sensitivity and presynaptic inhibition of glutamatergic sensory neurotransmission in vitro. J. Neurosci. 14:1994;2800-2808.
4. Hara K., Saito Y., Kirihara Y., Sakura S., Kosaka Y. Antinociceptive effects of intrathecal L-type calcium channel blockers on visceral and somatic stimuli in the rat. Anesth. Analg. 87:1998;382-387.
5. Hargreaves K., Dubner R., Brown F., Flores C., Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 32:1988;77-88.
6. Huang L.M. Calcium channels in isolated rat dorsal horn neurons, including labeled spinothalamic and trigeminothalamic cells. J. Physiol. (Lond.). 411:1989;161-177.
7. 2+ channel density in rat tissue. J. Pharmacol. Exp. Ther. 263:(2):1992;540-545.
8. Miller R.J. Presynaptic receptors. Annu. Rev. Pharmacol. Toxicol. 38:1998;201-227.
9. Miranda H.F., Pelissier T., Sierralta F. Analgesic effects of intracerebroventricular administration of calcium channel blockers in mice. Gen. Pharmacol. 24:1993;201-204.
10. Neugebauer V., Vanegas H., Nebe J., Rumenapp P., Schaible H.G. Effects of N- and L-type calcium channel antagonists on the responses of nociceptive spinal cord neurons to the mechanical stimulation of the normal and the inflamed knee joint. J. Neurophysiol. 76:1996;3740-3749.
11. Paquette F., Jasmin G., Dumont L. Cardioprotective efficacy of verapamil and mibefradil in young UM-X7.1 cardiomyopathic hamsters. Cardiovasc. Drugs Ther. 13:1999;525-530.
12. INVEST Investigators, Pepine C.J., Handberg E.M., Cooper-DeHoff R.M., Marks R.G., Kowey P., Messerli F.H., Manciam G., Cangiano J.L., Garcia-Barreto D., Keltai M., Erdine S., Bristol H.A., Kolb H.R., Bakris G.L., Cohen J.D., Parmley W.W. A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial. J. Am. Med. Assoc. 290:(21):2003;2805-2816.
13. 2+ channels. Brain Res. Brain Res. Rev. 40:2001;223-229.
14. Ryu P.D., Randic M. Low- and high-voltage-activated calcium currents in rat spinal dorsal horn neurons. J. Neurophysiol. 63:1990;273-285.
15. Scroggs R.S., Fox A.P. Calcium current variation between acutely isolated rat dorsal root ganglion neurons of different size. J. Physiol. (Lond.). 445:1992;639-658.
16. Todorovic S.M., Meyenburg A., Jevtovic-Todorovic V. Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker. Brain Res. 951:2002;336-340.
17. Vadlamudi L., Wijdicks E.F. Multifocal myoclonus due to verapamil overdose. Neurology. 58:2002;984-985.
18. Voisin D.L., Nagy F. Sustained L-type calcium currents in dissociated deep dorsal horn neurons of the rat: characteristics and modulation. Neuroscience. 102:2001;461-472.
19. White D.M., Cousins M.J. Effect of subcutaneous administration of calcium channel blockers on nerve injury-induced hyperalgesia. Brain Res. 801:1998;50-58.
20. 2+) channel blockers inhibit the development but not the expression of sensitization to morphine in mice. Eur. J. Pharmacol. 467:2003;145-150.