Molecular Biology of Growth-Hormone-Secreting Human Pituitary Tumours: Biochemical Consequences and Potential Clinical Significance

Acta Neurochirurgica, Supplement

Volumn 1996, Issue 65, 1996, Pages 7-10

  Adams, E F ^a   Buchfelder, M ^a   Lei, T ^a   Petersen, B ^a   Fahlbusch, R ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Acromegaly; GRF production; Gsp oncogenes; Molecular biology

Indexed keywords

GROWTH HORMONE RELEASING FACTOR; HORMONE RECEPTOR; HUMAN GROWTH HORMONE; NEUROPEPTIDE RECEPTOR; SOMATOCRININ RECEPTOR; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ACROMEGALY; ADENOMA; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HYPOPHYSIS TUMOR; MOLECULAR BIOLOGY; PHYSIOLOGY; REVIEW; SECRETION;

ACROMEGALY; ADENOMA; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH HORMONE-RELEASING HORMONE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMAN GROWTH HORMONE; HUMANS; MOLECULAR BIOLOGY; PITUITARY NEOPLASMS; RECEPTORS, NEUROPEPTIDE; RECEPTORS, PITUITARY HORMONE-REGULATING HORMONE;

EID: 1842690893     PISSN: 00651419     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-9450-8_3     Document Type: Article

References (18)

1. Adams EF, Brockmeier S, Friedman E, Roth M, Buchfelder M, Fahlbusch R (1993) Clinical and biochemical characteristics of acromegalic patients harboring gsp-positive and gsp-negative pituitary tumors. Neurosurgery 33: 198-203
2. Adams EF, Buchfelder M, Petersen B, Fahlbusch R (1994) Effect of pituitary adenylate-cyclase activating polypeptide on human somatotrophic tumours in cell culture. Endocrine 2: 75-79
3. Alexander JM, Biller BMK, Bikkal H, Zervas NT, Arnold A, Klibanski A (1990) Clinically non-functioning pituitary tumours are monoclonal in origin. J Clin Invest 86: 336-340
4. Boggild MD, Jenkinson S, Pistorello M, Boscaro M, Scanarini M, McTernan P, Perrett CW, Thakker RV, Clayton RN (1994) Molecular genetic studies of sporadic pituitary tumors. J Clin Endocrinol Metab 78: 387-392
5. Bourne HR (1987) Discovery of a new oncogene in pituitary tumours? Nature 330: 517-518
6. Clementi E, Malgaretti N, Meldolesi J, Taramelli R (1990) A new constitutively activating mutation of the Gs protein α subunit-gsp oncogene is found in human pituitary tumours. Oncogene 5: 1059-1061
7. Daniels M, Harrison D, Raghaven R, Birch P, Ince PG, James RA, Kendall-Taylor P (1993) C-myc immunoreactivity in human pituitary tumours. J Endocrinol 137 [Suppl]: 147
8. Faglia G (1993) Epidemiology and pathogenesis of pituitary adenomas. Acta Endocrinol 129 [Suppl 1]: 1-5
9. Harris PE, Alexander JM, Bikkal HA, Hsu DW, Hedley-Whyte ET, Klibanski A, Jameson JL (1992) Glycoprotein hormone α-subunit production in somatotroph adenomas with and without Gsα mutations. J Clin Endocrinol Metab 75: 918-923
10. Joubert D, Benlot C, Lagoguey A, Garnier P, Brandi AM, Gautron JP, Legrand JC, Peillon F (1989) Normal and growth hormone (GH)-secreting adenomatous human pituitaries release somatostatin and GH-releasing hormone. J Clin Endocrinol Metab 68: 572-577
11. Klibanski A (1990) Editorial: further evidence for a somatic mutation theory in the pathogenesis of human pituitary tumors. J Clin Endocrinol Metab 71: 1415A-1415C
12. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L (1989) GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 340: 692-696
13. Landis CA, Harsh G, Lyons J, Davis RL, McCormick F, Bourne HR (1990) Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein. J Clin Endocrinol Metab 71: 1416-1420
14. Levy A, Lightman SL (1992) Growth hormone-releasing hormone transcripts in human pituitary adenomas. J Clin Endocrinol Metab 74: 1474-1476
15. Melmed S (1993) Medical management of acromegaly what and when? Acta Endocrinol 129 [Suppl 1]: 13-17
16. Rivier J, Spiess J, Thorner MO, Vale W (1982) Characterization of a growth hormone-releasing factor from a human pancreatic islet tumor. Nature 300: 276-278
17. Spada A, Arosio M, Bochicchio D, Bazzoni N, Vallar L, Bassetti M, Faglia G (1990) Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with and without constitutively active adenylyl cyclase. J Clin Endocrinol Metab 71: 1421-1426
18. Wakabayashi I, Inokuchi K, Hasegawa O, Sugihara H, Minami S (1992) Expression of growth hormone (GH)-releasing factor gene in GH-producing pituitary adenoma. J Clin Endocrinol Metab 74: 357-361