Structure-activity relationships of epolactaene analogs as DNA polymerases inhibitors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 9, 2004, Pages 1983-1989

  Kuramochi, Kouji ^a   Mizushina, Yoshiyuki ^b   Nagata, Seigo ^a   Sugawara, Fumio ^a   Sakaguchi, Kengo ^a   Kobayashi, Susumu ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 DODECANOYL 3 DODECYL 4 HYDROXY 4 METHYL 6 OXA 3 AZABICYCLO[3.1.0]HEXAN 2 ONE; 1 DODECANOYL 4 METHOXY 4 METHYL 6 OXA 3 AZABICYCLO[3.1.0]HEXAN 2 ONE; 3 (1 HYDROXYETHYL)OXIRANE 2 CARBOXYLIC ACID AMIDE; 3 (1' HYDROXYETHYL)OXIRANE 2 CARBOXYLIC ACID DODECYLAMIDE; 3 (1' HYDROXYETHYL)OXIRANE 2 CARBOXYLIC ACID HEXYLAMIDE; 3 DODECYL 4 HYDROXY 4 METHYL 6 OXA 3 AZABICYCLO[3.1.0]HEXAN 2 ONE; 3 HEXYL 4 HYDROXY 4 METHYL 6 OXA 3 AZABICYCLO[3.1.0]HEXAN 2 ONE; 4 DODECYLOXY 4 METHYL 6 OXA 3 AZABICYCLO[3.1.0]HEXAN 2 ONE; 4 HEXYLOXY 4 METHYL 6 OXA 3 AZABICYCLO[3.1.0]HEXAN 2 ONE; 4 HYDROXY 4 METHYL 6 OXA 3 AZABICYCLO[3.1.0]HEXAN 2 ONE; ALKENE DERIVATIVE; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE BETA; DNA POLYMERASE INHIBITOR; ENZYME INHIBITOR; EPOLACTAENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; EPOXY COMPOUNDS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; POLYENES; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1842686948     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.007     Document Type: Article

References (19)

1. Kakeya H., Takahashi I., Okada G., Isono K., Osada H. J. Antibiot. 48:1995;733.
2. Hayashi Y., Narasaka K. Chem. Lett. 1998;313.
3. Hayashi Y., Kanayama J., Yamaguchi J., Shoji M. J. Org. Chem. 67:2002;9443.
4. Marumoto S., Kogen H., Naruto S. J. Org. Chem. 63:1998;2068.
5. Marumoto S., Kogen H., Naruto S. Tetrahedron. 55:1999;7129.
6. Marumoto S., Kogen H., Naruto S. Tetrahedron. 55:1999;7145.
7. Kuramochi K., Itaya H., Nagata S., Takao K., Kobayashi S. Tetrahedron Lett. 40:1999;7367.
8. Kuramochi K., Nagata S., Itaya H., Takao K., Kobayashi S. Tetrahedron Lett. 40:1999;7371.
9. Kuramochi K., Nagata S., Itaya H., Matsubara Y., Sunoki T., Uchiro H., Takao K., Kobayashi S. Tetrahedron. 59:2003;9743.
10. Kakeya H., Onozawa C., Sato M., Arai K., Osada H. J. Med. Chem. 40:1997;391.
11. Watabe M., Kakeya H., Osada H. Oncogene. 18:1999;5211.
12. Watabe M., Machida K., Osada H. Cancer Res. 60:2000;5214.
13. Mizushina Y., Kobayashi S., Kuramochi K., Nagata S., Sugawara F., Sakaguchi K. Biochem. Biophys. Res. Commun. 273:2000;784.
14. Nakai J., Kawada K., Nagata S., Kuramochi K., Uchiro H., Kobayashi S., Ikekita M. Biochim. Biophys. Acta. 1581:2002;1.
15. Ley S.V., Norman J., Griffith W.P., Marsden S.P. Synthesis. 1994;639.
16. Tamai K., Kojima K., Hanaichi T., Masaki S., Suzuki M., Umekawa H., Yoshida S. Biochim. Biophys. Acta. 950:1988;263.
17. Date T., Yamaguchi M., Hirose F., Nishimoto Y., Tanihara K., Matsukage A. Biochemistry. 27:1988;2983.
18. Mizushina Y., Tanaka N., Yagi H., Kurosawa T., Onoue M., Seto H., Horie T., Aoyagi N., Yamaoka M., Matsukage A., Yoshida S., Sakaguchi K. Biochim. Biophys. Acta. 1308:1996;256.
19. Mizushina Y., Yoshida S., Matsukage A., Sakaguchi K. Biochim. Biophys. Acta. 1336:1997;509.