The design, preparation and SAR of novel small molecule sodium (Na +) channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 9, 2004, Pages 2025-2030

  Ashwell, Mark A ^a   Lapierre, Jean Marc ^a   Kaplan, Alan ^a   Li, Jenny ^a   Marr, Christopher ^a   Yuan, Jin ^a  

^a ARQULE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDE DERIVATIVE; BENZAMIDE DERIVATIVE; CYTOCHROME P450 2D6; SODIUM CHANNEL BLOCKING AGENT; SODIUM ION;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SYNTHESIS; ENZYME ACTIVITY; IN VITRO STUDY; MOLECULAR MODEL; PHARMACOLOGICAL BLOCKING; PREDICTION; STRUCTURE ACTIVITY RELATION;

CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; MOLECULAR STRUCTURE; SODIUM CHANNEL BLOCKERS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1842640180     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.02.078     Document Type: Article

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