Mitomycin Does Not Prevent Laryngotracheal Repeat Stenosis after Endoscopic Dilation Surgery: An Animal Study

Laryngoscope

Volumn 114, Issue 4, 2004, Pages 743-746

  Eliashar, Ron ^a   Gross, Menachem ^a   Maly, Bella ^a   Sichel, Jean Yves ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

Larynx; Mitomycin; Scar; Subglottic stenosis; Wound healing

Indexed keywords

MITOMYCIN; SODIUM CHLORIDE; ALKYLATING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; ENDOSCOPIC SURGERY; LARYNX STENOSIS; NONHUMAN; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROPHYLAXIS; RECURRENT DISEASE; SCAR; SUBGLOTTIC STENOSIS; TRACHEA STENOSIS; TREATMENT FAILURE; WILCOXON SIGNED RANKS TEST; WOUND HEALING; ANIMAL; EVALUATION; GENERAL AND MISCELLANEOUS PROCEDURES AND TECHNIQUES; INSTRUMENTATION; LARYNGOSCOPY; METHODOLOGY; RANDOMIZATION;

ALKYLATING AGENTS; ANIMALS; DILATATION; DOGS; LARYNGOSCOPY; LARYNGOSTENOSIS; MITOMYCIN; RANDOM ALLOCATION; RECURRENCE; TRACHEAL STENOSIS;

EID: 1842610106     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-200404000-00028     Document Type: Article

References (25)

1. Hartnick CJ, Hartley BEJ, et al. Topical mitomycin application after laryngotracheal reconstruction. Arch Otolaryngol Head Neck Surg 2001;127:1260-1264.
2. Eliashar R, Eliachar I, Esclamado R, Gramlich T, Strome M. Can topical mitomycin prevent laryngotracheal stenosis? Laryngoscope 1999;109:1594-1600.
3. Eliashar R, Eliachar I, Gramlich T, Esclamado R, Strome M. Improved canine model for laryngotracheal stenosis. Otolaryngol Head Neck Surg 2000;122:84-90.
4. Correa AJ, Reinisch L, Sanders DL, et al. Inhibition of subglottic stenosis with mitomycin-c in the canine model. Ann Otol Rhinol Laryngol 1999;108:1053-1060.
5. Coppit G, Perkins J, Munaretto J, Nielsen R, McKinney L, Ulnick K. The effect of mitomycin-c and stenting on airway wound healing after laryngotracheal reconstruction in a pig model. Int J Pediatr Otolaryngol 2000;53:125-135.
6. Hardillo J, Vanclooster C, Delaere PR. An investigation of airway wound healing using a novel in vivo model. Laryngoscope 2001;111:1174-1182.
7. Garrett CG, Soto J, Riddick J, Billante CR, Reinisch L. Effect of mitomycin-c on vocal fold healing in a canine model. Ann Otol Rhinol Laryngol 2001;110:25-30.
8. Spector JE, Werkhaven JA, Spector NC, et al. Preservation of function and histologic appearance in the injured glottis with topical mitomycin-c. Laryngoscope 1999;109:1125-1129.
9. Rahbar R, Shapshay SM, Healy GB. Mitomycin: effects on laryngeal and tracheal stenosis, benefits, and complications. Ann Otol Rhinol Laryngol 2001;110:1-6.
10. Rahbar R, Jones DT, Nuss RC, et al. The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract. Arch Otolaryngol Head Neck Surg 2002;128:401-406.
11. Chan J, Akst LM, Eliachar I. The role of mitomycin-c in the endoscopic treatment of subglottic stenosis. Presented as a poster at the Annual Meeting of the American Academy of Otolaryngology - Head Neck Surgery, San Diego, CA, September 2002.
12. Valdez TA, Shapshay SM. Idiopathic subglottic stenosis revisited. Ann Otol Rhinol Laryngol 2002;111:690-695.
13. Singer AJ, Clark RAF. Cutaneous wound healing. N Engl J Med 1999;341:738-746.
14. Supance JS. Antibiotics and steroids in the treatment of acquired subglottic stenosis: a canine model study. Ann Otol Rhinol Laryngol 1983;92:377-382.
15. Croft CB, Zub K, Borowiecki B. Therapy of iatrogenic subglottic stenosis: a steroid/antibiotic regimen. Laryngoscope 1979;89:482-489.
16. Doolin EJ, Strande LF, Tsuno K, Santos MC. Pharmacologic inhibition of collagen in an experimental model of subglottic stenosis. Ann Otol Rhinol Laryngol 1998;107:275-279.
17. Campbell BH, Dennison BF, Durkin GE, Strigenz MA, Toohill RJ. Early and late dilation for acquired subglottic stenosis. Otolaryngol Head Neck Surg 1986;95:566-573.
18. Nowak P, Cohn AM, Guidice MA. Airway complications in patients with closed-head injuries. Am J Otol 1987;8:91-96.
19. Little FB, Koufman JA, Kohut RI, Marshall RB. Effect of gastric acid on the pathogenesis of subglottic stenosis. Ann Otol Rhinol Laryngol 1985;94:516-519.
20. Jindal JR, Milbrath MM, Shaker R, Hogan WJ, Toohill RJ. Gastroesophageal reflux disease as a likely cause of 'idiopathic' subglottic stenosis. Ann Otol Rhinol Laryngol 1994;103:186-191.
21. Yellon RF, Szeremeta W, Grandis JR, Diguisseppe P, Dickman PS. Subglottic injury, gastric juice, corticosteroids, and peptide growth factors in a porcine model. Laryngoscope 1998;108:854-862.
22. Eliashar R, Eliachar I, Gramlich T, Davros W, Moffet K, Strome M. Dynamic tissue expansion of the larynx in a canine model. Arch Otolaryngol Head Neck Surg 2001;127:309-315.
23. Kossi J, Aalto J, Haataja S, Niinikoski J, Peltonen J, Laato M. The effects of sialic acid on the gene expression of fibrillar collagens: different changes in normal and fibrotic scar derived fibroblasts. Ann Chir Gynaecol 2001;90(Suppl 215):25-28.
24. Kossi J, Peltonen J, Uotila P, Laato M. Differential effects of hexoses and sucrose, and platelet-derived growth factor isoforms on cyclooxygenase-1 and -2 mRNA expression in keloid, hypertrophic scar and granulation tissue fibroblasts. Arch Dermatol Res 2001;293:126-132.
25. Tonnesen MG, Feng X, Clark RA. Angiogenesis in wound healing. J Invest Dermatol Symp Proc 2000;5:40-46.