Immunization of rats with conjugates of dopamine and serotonin with bovine serum albumin prevents the development of experimental MPTP-induced depressive syndrome (electrophysiological parameters)

Neuroscience and Behavioral Physiology

Volumn 34, Issue 2, 2004, Pages 131-138

  Pankova, N B ^a   Vetrile L A ^a   Basharova, L A ^a   Krupina, N A ^a   Khlebnikova, N N ^a   Rodina, V I ^a   Kryzhanovskii, G N ^a  

^a INSTITUTE OF GENERAL PATHOLOGY AND PATHOPHYSIOLOGY   (Russian Federation)

Author keywords

Depressive syndrome; Dopamine; EEG; Immunization; MPTP; Rats; REM sleep; Serotonin

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BOVINE SERUM ALBUMIN; DOPAMINE; NEUROTRANSMITTER; SEROTONIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CAUDATE NUCLEUS; CONTROLLED STUDY; DEPRESSION; ELECTRIC ACTIVITY; EPILEPSY; IMMUNE STATUS; IMMUNIZATION; LATENT PERIOD; MALE; NEUROPROTECTION; NONHUMAN; PUTAMEN; RAT; REM SLEEP; TREATMENT OUTCOME;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES; DEPRESSION; DISEASE MODELS, ANIMAL; DOPAMINE; ELECTROPHYSIOLOGY; IMMUNIZATION; MALE; MPTP POISONING; POLYSOMNOGRAPHY; RATS; RATS, WISTAR; SEROTONIN; SERUM ALBUMIN, BOVINE; SLEEP, REM; VACCINES, CONJUGATE;

EID: 1842608940     PISSN: 00970549     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:NEAB.0000009207.38914.2b     Document Type: Article

References (28)

1. L. L. Basharova, V. A. Evseev, L. A. Vetrilé, et al., "INduction of antibodies to serotonin and catecholamines in rats treated chronically with morphine and signs of withdrawal syndrome," Byull. Éksperim. Biol. Med., 115, No. 5, 469 (1993).
2. N. N. Bogdanov, "TOwards an understanding of the phenomena of pharmacological electroencephalography," Zh. Vyssh. Nerv. Deyat., 44, No. 3, 403 (1994).
3. L. A. Vetrilé, N. A. Krupina, L. A. Basharova, et al, "A model of depressive syndrome in rats, induced by the neurotoxin MPTP and autoantibodies to serotonin and dopamine," Zh. Vyssh. Nerv. Deyat., 47, No. 4, 731 (1997).
4. T. E. Iordanskaya, N. A. Krupina, G. N. Kryzhanovskii, and I. M. Orlova, "THe effects of parlodel on measures of the sleep-waking cycle in rats with experimental MPTP-induced syndrome," Byull. Éksperim. Biol. Med., 127, No. 4, 380 (1999).
5. T. E. Iordanskaya, N. A. Krupina, G. N. Kryzhanovskii, and I. M. Orlova, "THe effects of parlodel on electrical activity in brain structures in an experimental depressive state," Byull. É ksperim. Biol. Med., 129, No. 2, 152 (2000).
6. N. A. Krupina, L. A. Vetrilé, E. V. Popkova, et al., "THe effects of active immunization with protein-conjugated dopamine and serotonin antigens on the development of experimental depressive syndrome and neurotransmitter levels in brain structures in rats," In: Neuroimmunopathology. Proceedings of the All-Russian Conference, 12-13 October 1999 [in Russian], Russian Academy of Medical Sciences Press, Moscow (1999), p. 46.
7. N. A. Krupina, G. N. Kryzhanovskii, T. E. Iordanskaya, et al., "IMpairments of REM sleep in experimental depressive syndrome induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to rats," Byull. Éksperim. Biol. Med., 123, No. 2, 138 (1997).
8. N. A. Krupina, G. N. Kryzhanovskii, T. E. Iordanskaya, and I. N. Orlova, "ELectrical activity in brain structures in experimental depressive syndrome induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to rats," Zh. Vyssh. Nerv. Deyat., 48, No. 2, 313 (1998).
9. N. A. Krupina, G. N. Kryzhanovskii, I. N. Orlova, and T. E. Iordanskaya, "THe effects of buspirone on the features of experimental depressive syndrome in rats, induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to rats," Byull. Éksperim. Biol. Med., 121, No. 5, 489 (1996).
10. N. A. Krupina, I. N. Orlova, and G. N. Kryzhanovskii, "A method for the integral assessment of the extent of depressive behavior in rats," Zh. Vyssh. Nerv. Deyat., 49, No. 5, 864 (1999).
11. N. A. Krupina, I. N. Orlova, and G. N. Kryzhanovskii, "THe effects of melipramine on the development of experimental depressive syndrome in rats, induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)," Byull. Éksperim. Biol. Med., 120, No. 8, 160 (1995).
12. N. A. Krupina, I. N. Orlova, and G. N. Kryzhanovskii, "THe effects of parlodel on the development of depressive syndrome in rats, induced by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)," Byull. Éksperim. Biol. Med., 120, No. 7, 66 (1995).
13. N. A. Krupina, E. N. Popkova, I. N. Orlova, et al., "THe effects of active immunization with a conjugate of dopamine and bovine serum albumin on the development of experimental MPTP-induced depressive syndrome and on monoamine metabolism in the rat brain," Zh. Vyssh. Nerv. Deyat., 50, No. 2, 287 (2000).
14. G. N. Kryzhanovskii, N. A. Krupina, and V. G. Kucheryanu, "A new model of experimental depressive syndrome in rats, induced by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP ," Zh. Vyssh. Nerv. Deyat., 45, No. 2, 377 (1995).
15. N. B. Pankova, L.A. Vetrilé, L.A. Basharova, et al., "THe effects of immunization of rats with a conjugate of serotonin and bovine serum albumin on the structure of daytime sleep and brain electrical activity," Zh. Vyssh. Nerv. Deyat., 51, No. 5, 636 (2001).
16. N. B. Pankova, I. N. Orlova, L. A. Vetrilé, et al, "CHanges in brain electrical activity, the structure of daytime sleep, and the behavior of rats after immunization with a conjugate of dopamine with bovine systemic albumin," Zh. Vyssh. Nerv. Deyat., 51, No. 4, 494 (2001).
17. N. B. Pankova, E. V. Popkova, L. A. Vetrilé, et al., "CHanges in the structure of daytime sleep, electrical activity, and neurochemical characteristics of the brain in conditions of systemic administration of complete Freund's adjuvant and immunization with bovine serum albumin with complete Freund's adjuvant," Zh. Vyssh. Nerv. Deyat., 51, No. 3, 339 (2001).
18. E. V. Popkova, N. A. Krupina, G. N. Kryzhanovskii, et al., "MOnoamine content in rat brain structures with MPTP-induced depressive syndrome," Byull. Éksperim. Biol. Med., 127, No. 1, 24 (1999).
19. M. P. Prozorovskaya, M. Yu. Eropkin, and I. P. Ashmarin, "THe effects of complete Freund's adjuvant on catecholamine levels in the adrenals and brain in rats," Zh. Mikrobiol. Épidemiol. Immunobiol., No. 10, 215 (1978).
20. A. S. Shevelev, "INteraction of the immune and nervous systems and the question of autoimmunity," Usp. Sovrem. Biol., 100, No. 2(5), 257 (1985).
21. I. Eysensehr, R. Linke, S. Noachtar, et al., "REduced striatal dopamine transporter in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson's disease and controls," Brain, 123, 1155 (2000).
22. J. D. Fernstrom and R. H. Pastel, "THe neuropharmacology of serotonin aId sleep: An evaluation," in: Animal Models of Depression, G. F. Koob, C. L. Ehlers, and D. J. Kupfer (eds.), Birkhauser, Boston, Basel, Berlin (1989), p. 261.
23. R. W. Fuller, "COmparison of MPTP and amphetamines as dopaminergic neurotoxines," In: Neurotoxines and Neurodegenerative Disease, J. W. Langston and A. B. Young (eds.), Ann. N.Y. Acad. Sci, Vol. 648, Part IV, p. 87 (1992).
24. J. C. Gillin, S. Inkwell-Israel, and M. Erman, "SLeep and sleep-wake disorders," In: Psychiatry. A. Tasman, J. Kay, and J. C. Lieberman (eds.), W. B. Saunder Co., Philadelphia (1996), p. 1217.
25. F. Godefroy, J. Weil-Fugazza, and J. V. Besson, "COmplex temporal changes in 5-hydroxytryptamine synthesis in the central nervous system induced by experimental polyarthritis in the rat," Pain, 28, No. 2, 223 (1987).
26. G. Nevander, M. Ingvar, and O. Lindvall, "MEchanisms of epileptic brain damage: Evidence for a protective role of the noradrenergic locus coeruleus in the rat," Exptl. Brain Res., 63, No. 4, 439 (1986).
27. Y. Qiu, Y. Peng, and J. Wang, "IMmunoregulatory role of neurotransmitters," Adv. Neuroimmunol., 6, No. 3, 223 (1996).
28. D. Riemann, F. Hohagen, M. Bahro, and M. Berger, "SLeep in depression: The influence of age, gender and diagnostic subtype on baseline sleep and cholinergic REM induction test with RS 86," Eur. Arch. Psych. Clin. Neurosci., 243, No. 5, 279 (1994).