Characterization of the generation of radiolabeled monodisperse albuterol particles using the spinning-top aerosol generator

Journal of Nuclear Medicine

Volumn 45, Issue 1, 2004, Pages 69-73

  Usmani, Omar S ^a   Biddiscombe, Martyn F ^b   Underwood, S Richard ^b   Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

2 agonist; Lung aerosol deposition; Particle size; Planar scintigraphy

Indexed keywords

SALBUTAMOL; TECHNETIUM 99M; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT; TECHNETIUM;

ARTICLE; IN VITRO SELECTION; ISOTOPE LABELING; PRIORITY JOURNAL; SCINTIGRAPHY; ADULT; AEROSOL; ASTHMA; CHEMISTRY; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; EVALUATION; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; INSTRUMENTATION; LUNG; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; NEBULIZER; PARTICLE SIZE; SCINTISCANNING; SYNTHESIS; VALIDATION STUDY;

ADMINISTRATION, INHALATION; ADULT; AEROSOLS; ALBUTEROL; ASTHMA; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; ISOTOPE LABELING; LUNG; METABOLIC CLEARANCE RATE; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; RADIOPHARMACEUTICALS; TECHNETIUM;

EID: 1842592764     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Gonda I. Scintigraphic techniques for measuring in vivo deposition. J Aerosol Med. 1996;9:S59-S67.
2. Newman SP, Widing IR, Hirst PH. Human lung deposition data: the bridge between in vitro and clinical evaluations for inhaled drug products? Int J Pharm. 2000;208:49-60.
3. Dolovich MB. Measuring total and regional lung deposition using inhaled radiotracers. J Aerosol Med. 2001;14:S35-S44.
4. Biddiscombe MF, Melcher R, Mak VHF, et al. The lung deposition of salbutamol, directly labelled with technetium-99m, delivered by pressurised metered dose inhaler and dry powder inhalers. Int J Pharm. 1993;91:111-121.
5. Newman SP, Clark AR, Talaee N, Clarke S. Pressurised aerosol deposition in the human lung with and without an "open" spacer device. Thorax. 1989;44:706-710.
6. Leach CL, Davidson PJ, Boudreau RJ. Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. Eur Respir J. 1998;12:1346-1353.
7. Morrow PE. An evaluation of the physical properties of monodisperse and heterodisperse aerosols used in the assessment of bronchial function. Chest. 1981;80:809-812.
8. 99mTc-labelled iron oxide aerosols for human lung deposition and clearance studies. Int J Appl Radiat Isot. 1980;31:689-694.
9. Agnew JE, Bateman JRM, Pavia D, Clarke SW. A model for assessing bronchial mucus transport. J Nuc Med. 1984;24:170-176.
10. Brown JS, Zeman KL, Bennett WD. Regional deposition of coarse particles and ventilation distribution in healthy subjects and patients with cystic fibrosis. J Aerosol Med. 2001;14:443-454.
11. Biddiscombe MF, Usmani OS, Barnes PJ. A system for the production and delivery of monodisperse salbutamol aerosols to the lungs. Int J Pharm. 2003;254:243-253.
12. Snell NJC, Ganderton D. Assessing lung deposition of inhaled medications. Respir Med. 1999;93:123-133.
13. Newman SP, Wilding IR. Imaging techniques for assessing drug delivery in man. Pharm Sci Technol Today. 1999;2:181-189.
14. Yeates DB, Aspin N, Bryan AC, Levison H. Regional clearance of ions from the airways of the lung. Am Rev Respir Dis. 1973;107:602-608.
15. Rinderknecht J, Shapiro L, Krauthammer M, et al. Accelerated clearance of small solutes from the lungs in interstitial lung disease. Am Rev Respir Dis. 1980;121:105-117.
16. 99mTc. J Aerosol Med. 1996;9:S27-S36.
17. Conway J, Fleming J, Holgate S. Three-dimensional imaging of inhaled aerosols. Eur Respir Rev. 1997;7:180-183.