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Go C, Schwartz MR, Donovan DT: Molecular transformation of recurrent respiratory papillomatosis: viral typing and p53 overexpression. Ann Otol Rhinol Laryngol 2003, 112:298-302. This is an interesting case series that emphasizes the difficulty of managing malignant transformation in this disease.
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Herrero R: Human papillomavirus and cancer of the upper aerodigestive tract. J Natl Cancer Inst Monogr 2003, 47-51. This is an excellent and concise review of the current evidence on HPV and its possible role in laryngeal and oropharyngeal cancer. It highlights the limitations of studies so far and provides useful suggestions for further research.
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Balz V, Scheckenbach K, Gotte K, et al.: Is the p53 inactivation frequency in squamous cell carcinomas of the head and neck underestimated? Analysis of p53 exons 2-11 and human papillomavirus 16/18 E6 transcripts in 123 unselected tumor specimens. Cancer Res 2003, 63:1188-1191. In this series, the laryngeal cases show a much higher level of p53 mutation than previous studies. The authors propose that p53 inactivation is an obligatory step.
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Gelder CM, Williams OM, Hart KW, et al.: HLA class II polymorphisms and susceptibility to recurrent respiratory papillomatosis. J Virol 2003, 77:1927-1939. This study found a pointer toward why certain patients are susceptible to laryngeal papillomatosis and probably, therefore, HPV-associated malignant transformation. This is an important area of future research.
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J Virol
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