Neoplasms associated with paraneoplastic pemphigus: A review with emphasis on non-hematologic malignancy and oral mucosal manifestations

Oral Oncology

Volumn 40, Issue 6, 2004, Pages 553-562

  Kaplan, Ilana ^a,b   Hodak, Emmilia ^a,b   Ackerman, Lehavit ^b   Mimouni, Daniel ^b   Anhalt, Grant J ^c   Calderon, Shlomo ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b RABIN MEDICAL CENTER   (Israel)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Carcinoma; Occult tumor; Paraneoplastic pemphigus; Sarcoma

Indexed keywords

ANTIESTROGEN; ANTIFUNGAL AGENT; CA 15-3 ANTIGEN; CANCER ANTIBODY; COMPLEMENT COMPONENT C3; CORTICOSTEROID; DESMOPLAKIN; DEXAMETHASONE; ENVOPLAKIN; HORMONE RECEPTOR; IMMUNOGLOBULIN G; NONSTEROID ANTIINFLAMMATORY AGENT; PERIPLAKIN; PREDNISONE; PROGESTERONE; ROFECOXIB; TRIAMCINOLONE;

ADENOCARCINOMA; ADULT; ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; BACTERIAL INFECTION; BASAL CELL CARCINOMA; BREAST CANCER; CANCER PATIENT; CARCINOMA; CASE REPORT; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL FEATURE; CORTICOSTEROID THERAPY; DENDRITIC CELL; DISEASE COURSE; ELECTROLYTE DISTURBANCE; ERYTHEMA MULTIFORME; FEMALE; HEART ATRIUM FIBRILLATION; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; LEIOMYOSARCOMA; LIPOSARCOMA; LOZENGE; LUNG CARCINOMA; MELANOMA; MOUTH MUCOSA; MOUTH ULCER; NERVE SHEATH TUMOR; NONHODGKIN LYMPHOMA; ORAL BIOPSY; OVARY CYST; PARANEOPLASTIC SYNDROME; PEMPHIGUS; PLASMA CELL GRANULOMA; PRIORITY JOURNAL; RETICULOSARCOMA; REVIEW; SARCOMA; SEPSIS; SQUAMOUS CELL CARCINOMA;

ADENOCARCINOMA; BREAST NEOPLASMS; CARCINOMA, SQUAMOUS CELL; FATAL OUTCOME; FEMALE; HUMANS; MIDDLE AGED; OVARIAN CYSTS; OVARIAN NEOPLASMS; PARANEOPLASTIC SYNDROMES; PEMPHIGUS;

EID: 1842582053     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2003.09.020     Document Type: Review

References (93)

1. Anhalt G.J., Kim S.C., Stanley J.R.et al. Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N. Engl. J. Med. 323(25):1990;1729-1735.
2. Kimyai-Asadi A., Jih M.H. Paraneoplastic pemphigus. Int. J. Dermatol. 40(6):2001;367-372.
3. Joly P., Richard C., Gilbert D.et al. Sensitivity and specificity of clinical, histologic, and immunologic features in the diagnosis of paraneoplastic pemphigus. J. Am. Acad. Dermatol. 43(4):2000;619-626.
4. Bialy-Golan A., Brenner S., Anhalt G.J. Paraneoplastic pemphigus: oral involvement as the sole manifestation. Acta. Derm. Venereol. 76(3):1996;253-254.
5. Nguyen V.T., Ndoye A., Bassler K.D.et al. Classification, clinical manifestations, and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome: a reappraisal of paraneoplastic pemphigus. Arch. Dermatol. 137(2):2001;193-206.
6. Camisa C., Helm T.N. Paraneoplastic pemphigus is a distinct neoplasia-induced autoimmune disease. Arch. Dermatol. 129(7):1993;883-886.
7. Fullerton S.H., Woodley D.T., Smoller B.R., Anhalt G.J. Paraneoplastic pemphigus with autoantibody deposition in bronchial epithelium after autologous bone marrow transplantation. JAMA. 267(11):1992;1500-1502.
8. Oursler J.R., Labib R.S., Arris-Abdo L., Burke T., O'Keefe E.J., Anhalt G.J. Human antibodies against desmoplakins in paraneoplastic pemphigus. J. Clin. Invest. 89(6):1992;775-782.
9. Horn T.D., Anhalt G.J. Histologic features of paraneoplastic pemphigus. Arch. Dermatol. 128(8):1992;1091-1095.
10. Camisa C., Helm T.N., Liu Y.C.et al. Paraneoplastic pemphigus: a report of three cases including one long-term survivor. J. Am. Acad. Dermatol. 27(4):1992;547-553.
11. Meyers S.J., Varley G.A., Meisler D.M., Camisa C., Wander A.H. Conjunctival involvement in paraneoplastic pemphigus. Am. J. Ophthalmol. 114(5):1992;621-624.
12. Helm T.N., Camisa C., Valenzuela R., Allen C.M. Paraneoplastic pemphigus. A distinct autoimmune vesiculobullous disorder associated with neoplasia. Oral Surg. Oral Med. Oral Pathol. 75(2):1993;209-213.
13. Rybojad M., Leblanc T., Flageul B.et al. Paraneoplastic pemphigus in a child with a T-cell lymphoblastic lymphoma. Br. J. Dermatol. 128(4):1993;418-422.
14. Mutasim D.F., Pelc N.J., Anhalt G.J. Paraneoplastic pemphigus. Dermatol. Clin. 11(3):1993;473-481.
15. Fried R., Lynfield Y., Vitale P., Anhalt G. Paraneoplastic pemphigus appearing as bullous pemphigoid-like eruption after palliative radiation therapy. J. Am. Acad. Dermatol. 29(5 Pt 2):1993;815-817.
16. Tankel M., Tannenbaum S., Parekh S. Paraneoplastic pemphigus presenting as an unusual bullous eruption. J. Am. Acad. Dermatol. 29(5 Pt 2):1993;825-828.
17. Joly P., Thomine E., Gilbert D.et al. Overlapping distribution of autoantibody specificities in paraneoplastic pemphigus and pemphigus vulgaris. J. Invest. Dermatol. 103(1):1994;65-72.
18. Lotem M., Trattner A., Ingber A. Paraneoplastic pemphigus: revaluation of a case from the past. Arch. Dermatol. 130(11):1994;1454.
19. Hashimoto T., Watanabe K., Ishiko A.et al. A case of bullous pemphigoid with antidesmoplakin autoantibodies. Br. J. Dermatol. 131(5):1994;694-699.
20. Lee M.S., Kossard S., Ho K.K., Barnetson R.S., Ravich R.B. Paraneoplastic pemphigus triggered by radiotherapy. Australas. J. Dermatol. 36(4):1995;206-210.
21. Nishibori Y., Hashimoto T., Ishiko A., Shimizu H., Korman N.J., Nishikawa T. Paraneoplastic pemphigus: the first case report from Japan. Dermatology. 191(1):1995;39-42.
22. Plumb R., Doolittle G.C. Paraneoplastic pemphigus in a patient with non-Hodgkin's lymphoma. Am. J. Hematol. 52(1):1996;58-59.
23. Herrada J., Phillips D.K., Hebert A.A., Cabanillas F., Jordon R.E. A progressive blistering eruption in a patient with lymphoma. Paraneoplastic pemphigus. Arch. Dermatol. 133(1):1997;97. 100-1.
24. Osmanski J.P. 2nd, Fraire A.E., Schaefer O.P. Necrotizing tracheobronchitis with progressive airflow obstruction associated with paraneoplastic pemphigus. Chest. 112(6):1997;1704-1707.
25. Schlesinger T., McCarron K., Camisa C., Anhalt G. Paraneoplastic pemphigus occurring in a patient with B-cell non-Hodgkin's lymphoma. Cutis. 61(2):1998;94-96.
26. Mahler V., Antoni C., Anhalt G.J.et al. Graft-versus-host-like mucocutaneous eruptions with serological features of paraneoplastic pemphigus and systemic lupus erythematosus in a patient with non-Hodgkin's lymphoma. Dermatology. 197(1):1998;78-83.
27. Beylot-Barry M., Doutre M.S., Vergier B.et al. Pemphigus paraneoplastic lichenoide au cours d'un lymphoma de bas grade. Ann. Dermatol. Venereol. 125(10):1998;720-723.
28. van der Waal R.I., Pas H.H., Anhalt G.J., Schulten E.A., Jonkman M.F., Nieboer C. Paraneoplastic pemphigus as the presenting symptom of a lymphoma of the tongue. Oral Oncol. 34(6):1998;567-570.
29. Favia G.F., Di Alberti L., Piattelli A. Paraneoplastic pemphigus: a report of two cases. Oral Oncol. 34(6):1998;571-575.
30. Passeron T., Bahadoran P., Lacour J.P.et al. Paraneoplastic pemphigus presenting as erosive lichen planus. Br. J. Dermatol. 140(3):1999;552-553.
31. Hasegawa Y., Shimokata K., Ichiyama S., Saito H. Constrictive bronchiolitis obliterans and paraneoplastic pemphigus. Eur. Respir. J. 13(4):1999;934-937.
32. Reich K., Brinck U., Letschert M., Blaschke V.et al. Graft-versus-host disease-like immunophenotype and apoptotic keratinocyte death in paraneoplastic pemphigus. Br. J. Dermatol. 141(4):1999;739-746.
33. Hertzberg M.S., Schifter M., Sullivan J., Stapleton K. Paraneoplastic pemphigus in two patients with B-cell non-Hodgkin's lymphoma: significant responses to cyclophosphamide and prednisolone. Am. J. Hematol. 63(2):2000;105-106.
34. Takahashi M., Shimatsu Y., Kazama T., Kimura K., Otsuka T., Hashimoto T. Paraneoplastic pemphigus associated with bronchiolitis obliterans. Chest. 117(2):2000;603-607.
35. Bowen G.M., Peters N.T., Fivenson D.P.et al. Lichenoid dermatitis in paraneoplastic pemphigus: a pathogenic trigger of epitope spreading? Arch. Dermatol. 136(5):2000;652-656.
36. Bouloc A., Joly P., Saint-Leger E., Wechsler J., Roujeau J.C., Revuz J. Paraneoplastic pemphigus with circulating antibodies directed exclusively against the pemphigus vulgaris antigen desmoglein 3. J. Am. Acad. Dermatol. 43(4):2000;714-717.
37. Borradori L., Lombardi T., Samson J., Girardet C., Saurat J.H., Hugli A. Anti-CD20 monoclonal antibody (rituximab) for refractory erosive stomatitis secondary to CD20 (+) follicular lymphoma-associated paraneoplastic pemphigus. Arch. Dermatol. 137(3):2001;269-272.
38. Heizmann M., Itin P., Wernli M., Borradori L., Bargetzi M.J. Successful treatment of paraneoplastic pemphigus in follicular NHL with rituximab: report of a case and review of treatment for paraneoplastic pemphigus in NHL and CLL. Am. J. Hematol. 66(2):2001;142-144.
39. Marzano A.V., Grammatica A., Cozzani E., Terracina M., Berti E. Paraneoplastic pemphigus. A report of two cases associated with chronic B-cell lymphocytic leukaemia. Br. J. Dermatol. 145(1):2001;127-131.
40. Stevens S.R., Griffiths C.E., Anhalt G.J., Cooper K.D. Paraneoplastic pemphigus presenting as a lichen planus pemphigoides-like eruption. Arch. Dermatol. 129(7):1993;866-869.
41. Joly P., Gilbert D., Thomine E.et al. Immunofluorescence and immunoelectron microscopy analyses of a human monoclonal anti-epithelial cell surface antibody that recognizes a 185-kD polypeptide: a component of the paraneoplastic pemphigus antigen complex? J. Invest. Dermatol. 101(3):1993;339-345.
42. Su W.P., Oursler J.R., Muller S.A. Paraneoplastic pemphigus: a case with high titer of circulating anti-basement membrane zone autoantibodies. J. Am. Acad. Dermatol. 30(5 Pt 2):1994;841-844.
43. Rodot S., Botcazou V., Lacour J.P.et al. Le pemphigus paraneoplastique: revue de la literature, a prppos d'un cas associe a une leucemie lymphoide chronique. Rev. Med. Inerne. 16(12):1995;938-943.
44. Bazarbachi A., Bachelez H., Dehen L., Delmer A., Zittoun R., Dubertret L. Lethal paraneoplastic pemphigus following treatment of chronic lymphocytic leukaemia with fludarabine. Ann. Oncol. 6(7):1995;730-731.
45. Izaki S., Yoshizawa Y., Kitamura K.et al. Paraneoplastic pemphigus: potential therapeutic effect of plasmapheresis. Br. J. Dermatol. 134(5):1996;987-999.
46. Fournier B., Bouscarat F., Le-Bozec P.et al. Pemphigus noeplastique au cours d'une leucemie lymphoide chronique. Ann. Dermatol. Venereol. 123(8):1996;483-486.
47. Segard-Drouard M., Lefebvre I., Catteau B.et al. Pemphigus neoplastoue avec atteinte tracheo-bronchique. Ann. Dermatol. Venereol. 124(9):1997;615-618.
48. Sapadin A.N., Anhalt G.J. Paraneoplastic pemphigus with a pemphigus vegetans-like plaque as the only cutaneous manifestation. J. Am. Acad. Dermatol. 39(5 Pt 2):1998;867-871.
49. Nousari H.C., Brodsky R.A., Jones R.J., Grever M.R., Anhalt G.J. Immunoablative high-dose cyclophosphamide without stem cell rescue in paraneoplastic pemphigus: report of a case and review of this new therapy for severe autoimmune disease. J. Am. Acad. Dermatol. 40(5 Pt 1):1999;750-754.
50. Williams J.V., Marks J.G. Jr., Billingsley E.M. Use of mycophenolate mofetil in the treatment of paraneoplastic pemphigus. Br. J. Dermatol. 142(3):2000;506-508.
51. Martel P., Gilbert D., Labeille B., Kanitakis J., Joly P. A case of paraneoplastic pemphigus with antidesmoglein 1 antibodies as determined by immunoblotting. Br. J. Dermatol. 142(4):2000;812-813.
52. van Mook W.N.K., Fickers M.M., Theunissen P.H.et al. Paraneoplastic pemphigus as the initial presentation of chronic lymphocytic leukemia. Ann. Oncol. 12(1):2001;115-118.
53. Rivollier C., Vaillant L., Machet M.C.et al. Pemphigus neoplastique. Une forme pustuleuse au cours d'une leucemie lymphoide chronique. Ann. Dermatol. Venereol. 128(5):2001;644-648.
54. Gooptu C., Littlewood T.J., Frith P.et al. Paraneoplastic pemphigus: an association with fludarabine? Br. J. Dermatol. 144(6):2001;1255-1261.
55. Jansen T., Plewig G., Anhalt G.J. Paraneoplastic pemphigus with clinical features of erosive lichen planus associated with Castleman's tumor. Dermatology. 190(3):1995;245-250.
56. Lemon M.A., Weston W.L., Huff J.C. Childhood paraneoplastic pemphigus associated with Castleman's tumour. Br. J. Dermatol. 136(1):1997;115-117.
57. Kim S.C., Chang S.N., Lee I.J.et al. Localized mucosal involvement and severe pulmonary involvement in a young patient with paraneoplastic pemphigus associated with Castleman's tumour. Br. J. Dermatol. 138(4):1998;667-671.
58. Wolff H., Kunte C., Messer G., Rappersberger K.et al. Paraneoplastic pemphigus with fatal pulmonary involvement in a woman with a mesenteric Castleman tumour. Br. J. Dermatol. 140(2):1999;313-316.
59. Lee I.J., Kim S.C., Kim H.S.et al. Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma arising from Castleman's tumor. J. Am. Acad. Dermatol. 40(2 Pt 2):1999;294-297.
60. Irsutti M., Paul J.L., Selves J., Railhac J.J. Castleman disease: CT and MR imaging features of a retroperitoneal location in association with paraneoplastic pemphigus. Eur. Radiol. 9(6):1999;1219-1221.
61. Mascaro J.M. Jr., Ferrando J., Sole M.T.et al. Paraneoplastic pemphigus: a case of long-term survival associated with systemic lupus erythematosus and polymyositis. Dermatology. 199(1):1999;63-66.
62. Chorzelski T., Hashimoto T., Maciejewska B., Amagai M., Anhalt G.J., Jablonska S. Paraneoplastic pemphigus associated with Castleman tumor, myasthenia gravis and bronchiolitis obliterans. J. Am. Acad. Dermatol. 41(3 Pt 1):1999;393-400.
63. Hsiao C.J., Hsu M.M., Lee J.Y., Chen W.C., Hsieh W.C. Paraneoplastic pemphigus in association with a retroperitoneal Castleman's disease presenting with a lichen planus pemphigoides-like eruption. A case report and review of literature. Br. J. Dermatol. 44(2):2001;372-376.
64. Chin A.C., Stich D., White F.V., Radhakrishnan J., Holterman M.J. Paraneoplastic pemphigus and bronchiolitis obliterans associated with a mediastinal mass: a rare case of Castleman's disease with respiratory failure requiring lung transplantation. J. Pediatr. Surg. 36(12):2001;E22.
65. Mimouni D., Anhalt G.J., Lazarova Z.et al. Paraneoplastic pemphigus in children and adolescents. Br. J. Dermatol. 147:2002;725-732.
66. Norris D.L., Saywell M.S., Strutton G.M., Stephenson G.J. Pemphigus vulgaris associated with spindle cell thymoma. Australas. J. Dermatol. 34(3):1993;97-102.
67. Ishii M., Izumi J., Fujiwara H., Ito M., Hamada M. Immunoblotting detection of gamma-catenin (plakoglobin) antibody in the serum of a patient with paraneoplastic pemphigus. Br. J. Dermatol. 144(2):2001;377-379.
68. Inaoki M., Kodera M., Fujimoto A., Nousari H.C., Anhalt G.J., Takehara K. Paraneoplastic pemphigus without antidesmoglein 3 or antidesmoglein 1 antibodies. Br. J. Dermatol. 44(3):2001;610-613.
69. Leyn J., Degreef H. Paraneoplastic pemphigus in a patient with a thymoma. Dermatology. 202(2):2001;151-154.
70. Perniciaro C., Kuechle M.K., Colon-Otero G., Raymond M.G., Spear K.L., Pittelkow M.R. Paraneoplastic pemphigus: a case of prolonged survival. Mayo. Clin. Proc. 69(9):1994;851-855.
71. Kirsner R.S., Anhalt G.J., Kerdel F.A. Treatment with alpha interferon associated with the development of paraneoplastic pemphigus. Br. J. Dermatol. 132(3):1995;474-478.
72. Becker L.R., Bastian B.C., Wesselmann U., Karl S., Hamm H., Brocker E.B. Paraneoplastic pemphigus treated with dexamethasone/cyclophosphamide pulse therapy. Eur. J. Dermatol. 8(8):1998;551-553.
73. Dega H., Laporte J.L., Joly P.et al. Paraneoplastic pemphigus associated with Hodgkin's disease. Br. J. Dermatol. 138(1):1998;196-198.
74. Lam S., Stone M.S., Goeken J.A.et al. Paraneoplastic pemphigus, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy in a patient with bronchogenic squamous cell carcinoma. Ophthalmology. 99(1):1992;108-113.
75. Rongioletti F., Truchetet F., Rebora A. Paraneoplastic pemphigoid-pemphigus? Subepidermal bullous disease with pemphigus-like direct immunofluorescence. Int. J. Dermatol. 32(1):1993;48-51.
76. Chamberland M. Pemphigus paraneoplastique et adenocarcinoma du colon. Union Med. Can. 122(3):1993;201-213.
77. Matz H., Milner Y., Frusic-Zlotkin M., Brenner S. Paraneoplastic pemphigus associated with pancreatic carcinoma. Acta. Derm. Venereol. 77(4):1997;289-291.
78. Wong K.C., Ho K.K. Pemphigus with pemphigoid-like presentation, associated with squamous cell carcinoma of the tongue. Australas. J. Dermatol. 41(3):2000;178-180.
79. Berg W.A., Fishman E.K., Anhalt G.J. Retroperitoneal reticulum cell sarcoma: a cause of paraneoplastic pemphigus. South Med. J. 86(2):1993;215-217.
80. Krunic A.L., Kokai D., Bacetic B.et al. Retroperitoneal round-cell liposarcoma associated with paraneoplastic pemphigus presenting as lichen planus pemphigoides-like eruption. Int. J. Dermatol. 36(7):1997;526-529.
81. van der Waal R.I., Pas H.H., Nousari H.C.et al. Paraneoplastic pemphigus caused by an epithelioid leiomyosarcoma and associated with fatal respiratory failure. Oral Oncol. 36(4):2001;390-393.
82. Beele H., Claerhout I., Kestelyn P., Dierckxens L., Naeyaert J.M., De Laey J.J. Bilateral corneal melting in a patient with paraneoplastic pemphigus. Dermatology. 202(2):2001;147-150.
83. Schaeppi H., Bauer J.W., Hametner R.et al. A localized variant of paraneoplastic pemphigus: acantholysis associated with malignant melanoma. Br. J. Dermatol. 44(6):2001;1249-1254.
84. Schoen H., Foedinger D., Derfler K.et al. Immunoapheresis in paraneoplastic pemphigus. Arch. Dermatol. 134(6):1998;706-710.
85. Ostezan L.B., Fabre V.C., Caughman S.W., Swerlick R.A., Korman N.J., Callen J.P. Paraneoplastic pemphigus in the absence of a known neoplasm. J. Am. Acad. Dermatol. 33(2 Pt 1):1995;312-315.
86. Healy C.M., Thornhill M.H. An association between recurrent oro-genital ulceration and non-steroidal anti-inflammatory drugs. J. Oral Pathol. Med. 24(1):1995;46-48.
87. Valsecchi R., Resengheti A., Cainelli A. Bullous and erosive stomatitis induced by nimesulide. Dermatology. 185(1):1992;74-75.
88. Kaziro G.S. Oral ulceration and neutropenia associated with naproxen. Aust. Dent. J. 25(6):1980;333-334.
89. AHFS drug information. Maryland, USA: American Society of Health System Pharmacists; 2002. p. 2037.
90. Neville B.W., Damm D.D., Allen C.M., Bouquot J.E. Oral and maxillofacial pathology. 2nd ed. 2002;676-677 WB Saunders, Philadelphia.
91. Anhalt G.J. Paraneoplastic pemphigus. Adv. Dermatol. 12:1997;77-97.
92. Foroudi F., Tiver K.W. Occult breast carcinoma presenting as axillary metastases. Int. J. Radiat. Oncol. Biol. Phys. 47(1):2000;143-147.
93. Vlastos G., Jean M.E., Mirza A.N.et al. Feasibility of breast preservation in the treatment of occult primary carcinoma presenting with axillary metastases. Ann. Surg. Oncol. 8(5):2001;425-431.