Hyperfractionated accelerated radiotherapy alone and with concomitant chemotherapy to the head and neck: Treated within and outside of randomized clinical trials

International Journal of Radiation Oncology Biology Physics

Volumn 58, Issue 5, 2004, Pages 1424-1430

  Hehr, Thomas ^a   Classen, Johannes ^a   Schreck, Ulrike ^a   Glocker, Stefan ^a   Bamberg, Michael ^a   Budach, Wilfried ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Head and neck cancer; Radiochemotherapy; Randomization; Selection bias; Survival

Indexed keywords

CHEMOTHERAPY; DISEASES; PATIENT MONITORING; TUMORS;

CLINICAL TRIALS; RADIOCHEMOTHERAPY;

RADIOTHERAPY;

FLUOROURACIL; MITOMYCIN C;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CANCER RISK; CANCER STAGING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; HEAD AND NECK CANCER; HUMAN; MALE; PATIENT SELECTION; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SQUAMOUS CELL CARCINOMA; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; TUMOR LOCALIZATION;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; CARCINOMA, SQUAMOUS CELL; DOSE FRACTIONATION; FEMALE; FOLLOW-UP STUDIES; GERMANY; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; PATIENT SELECTION; SELECTION BIAS; SURVIVAL ANALYSIS;

EID: 1842581487     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2003.08.036     Document Type: Article

References (12)

1. Chen C., Skingley P., Meyer R.M. A comparison of elderly patients with aggressive histology lymphoma who were entered or not entered on to a randomized phase II trial. Leuk Lymphoma. 38:2000;327-334.
2. Gnant M, on behalf of the Austrian Breast & Colorectal Cancer Study Group, Vienna, Austria. Impact of participation in randomized clinical trials on survival of women with early stage breast cancer - An analysis of 7985 patients [Abstract]. Presented at the 36th Annual Meeting of the American Society for Clinical Oncology, 2000
3. Schmoor C., Olschewski M., Schumacher M. Randomized and non-randomized patients in clinical trials Experiences with comprehensive cohort studies. Stat Med. 15:1996;263-271.
4. Internationale Contre le Cancer. TNM classification of malignant tumors. 4th ed:1997;Springer-Verlag, New York.
5. Lee E.T. Statistical methods for survival data analysis. 1992;Wiley, New York.
6. Weissler M.C., Melin S., Sailer S.L., et al. Simultaneous chemoradiation in the treatment of advanced head and neck cancer. Arch Otolaryngol Head Neck Surg. 118:1992;806-810.
7. Budach V., Dinges S., Lammert I., et al. [Radiochemotherapy is more effective than dose escalation in locally advanced head and neck cancer: Results of a german multicentre randomized trial (ARO95-6)]. [in German] Strahlenther Onkol. 178:(Suppl. 1):2002;12.
8. Wendt T.G., Grabenbauer G.G., Rodel C.M., et al. Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer A randomized multicenter study. J Clin Oncol. 16:1998;1318-1324.
9. Jeremic B., Shibamoto Y., Milicic B., et al. Hyperfractionated radiation therapy with or without concurrent low-dose daily cisplatin in locally advanced squamous cell carcinoma of the head and neck A prospective randomized trial. J Clin Oncol. 18:2000;1458-1464.
10. Dobrowsky W., Naude J. Continuous hyperfractionated accelerated radiotherapy with/without mitomycin C in head and neck cancers. Radiother Oncol. 57:2000;119-124.
11. Staar S., Rudat V., Stuetzer H., et al. Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy: Results of a multicentric randomized German trial in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 50:2001;1161-1171.
12. Brizel D.M., Albers M.E., Fisher S.R., et al. Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med. 338:1998;1798-1804.