ISFET-neuron junction: Circuit models and extracellular signal simulations

Biosensors and Bioelectronics

Volumn 19, Issue 11, 2004, Pages 1487-1496

  Martinoia, Sergio ^a   Massobrio, Paolo ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Circuit model; Extracellular recording; HSPICE simulation; ISFET; Neuro electronic junction; Neuron

Indexed keywords

ADHESION; CAPACITANCE; CIRCUIT THEORY; COMPUTER SIMULATION; COUPLED CIRCUITS; ION SENSITIVE FIELD EFFECT TRANSISTORS; MATHEMATICAL MODELS; NETWORKS (CIRCUITS); SEALING (CLOSING);

ELECTRICAL ACTIVITY; NEURON JUNCTION;

BIOSENSORS;

ACTION POTENTIAL; CELL JUNCTION; CELL MEMBRANE RESISTANCE; CONFERENCE PAPER; ELECTRIC CURRENT; EXPERIMENTAL MODEL; EXTRACELLULAR SPACE; GEOMETRY; ION CURRENT; ION SENSITIVE FIELD EFFECT TRANSISTOR; MATHEMATICAL COMPUTING; MOLECULAR MODEL; NERVE CELL; NERVE CELL MEMBRANE; NERVE CELL NETWORK; PHYSICAL CHEMISTRY; RECORDING; SIGNAL TRANSDUCTION; SIMULATION; TRANSDUCER;

BIOPHYSICS; COMPUTER SIMULATION; ION-SELECTIVE ELECTRODES; MICROELECTRODES; MODELS, BIOLOGICAL; NEURONS;

EID: 1842557957     PISSN: 09565663     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bios.2003.12.003     Document Type: Conference Paper

References (29)

1. Bove M., Massobrio G., Martinoia S., Grattarola M. Realistic simulations of neurons by means of an ad hoc modified version of SPICE. Biol. Cybern. 71:1994;137-145.
2. Bove M., Martinoia S., Grattarola M., Ricci D. The neuron-transistor junction: linking equivalent electric circuit models to microscopic descriptions. Thin Solid Films. 284-285:1996;772-775.
3. Bove M., Martinoia S., Verreschi G., Giugliano M., Grattarola M. Analysis of the signals generated by networks of neurons coupled to planar arrays of microtransducers in simulated experiments. Biosens. Bioelectron. 13:1998;601-612.
4. Chua L.O. Device modeling via basic nonlinear circuit elements. IEEE Trans. Circuits Syst. CAS-27:1980;1014-1044.
5. Destexhe A., Mainen Z., Sejnowski T.J. An efficient method for computing synaptic conductances based on to kinetic model of receptor binding. Neural Comp. 6:1994;14-18.
6. Fromherz P., Offenhausser A., Vetter T., Weiss J.A. Neuron-silicon junction: a retzius cell of the leech on an insulated-gate field-effect transistor. Science. 252:1991;1290-1293.
7. Fromherz P., Muller C.O., Weis A. Neuron transistor: electrical transfer function measured by the patch-clamp technique. Phys. Rev. Lett. 71:1993;4079-4082.
8. Fromherz, P., 2003. Neuroelectronic interfacing: semiconductor chips with ion channels, nerve, cells, and brain. In: Waser, R. (Ed.), Nanoelectronics and Information Technology. Wiley-VCH, Berlin, 2003, pp. 781-810.
9. Grattarola M., Martinoia S. Modeling the neuron-microtransducer junction: from extracellular to patch recording. IEEE Trans. Biomed. Eng. 40:1993;35-41.
10. +-sensitive FET's with SPICE. IEEE Trans. Electron Devices ED-39, 813-819.
11. Gross, G.W., Kowalski, J.M., 1991. Experimental and theoretical analyses of random networks dynamics. In: Antognetti, P., Milutinovic, V. (Eds.), Neural Networks, Concepts, Application and Implementation, vol. IV. Prentice Hall, pp. 47-110.
12. Gross G.W., Azzazy H.M.E., Wu M.C., Rhodes B.K. The use of neuronal networks on multielectrode arrays as biosensors. Biosens. Bioelectron. 10:1995;553-567.
13. Hodgkin A.L., Huxley A.F. A quantitative description of membrane current and its application to conduction in nerve. J. Physiol. 117:1952;500-544.
14. Jenkner M., Muller B., Fromherz P. Interfacing a silicon chip to pairs of snail neurons connected by electrical synapses. Biol. Cybern. 84:2001;239-249.
15. Lorenzelli L., Margesin B., Martinoia S., Tedesco M.T., Valle M. Bioelectrochemical signal monitoring of in-vitro cultured cells by means of an automated microsystem based on solid state sensor-array. Biosens. Bioelectron. 18/5-6:2003;621-626.
16. Maeda E., Robinson H.P.C., Kawana A. The mechanisms of generation and propagation of syncronized bursting in developing networks of cortical neurons. J. Neurosci. 15:1995;6834-6845.
17. Martinoia S., Massobrio G. A behavioral macromodel of the ISFET in SPICE. Sens. Actuators. B62:2000;182-189.
18. Massobrio, G., Antognetti, P., 1993. Semiconductor Device Modeling with SPICE, second ed. McGraw-Hill.
19. Meta-Software Inc., 1992. HSPICE User's Manual. Campbell, CA, USA.
20. Newman J. Resistance for flow of current to a disk. J. Electrochem. Soc. 113:1966;501-502.
21. Owicki J.C., Parce J.W. Biosensors based on the energy metabolism of living cell: the physical chemistry and cell biology of extracellular acidification. Biosens. Bioelectron. 7:1992;255-272.
22. Rutten W., Mouveroux J.M., Buitenweg J., Heida C., Ruardij T., Marani E., Lakke E. Neuro-electronic interfacing with cultured multi electrode arrays toward a cultured probe. Proc. IEEE. 89:2001;1013-1029.
23. Schatzthauer R., Fromherz P. Neuron-silicon junction with voltage-gated ionic currents. Eur. J. Neurosci. 10:1998;1956-1962.
24. Segev, I., Fleshman, J.W., Miller, J.P., Bunow, B., 1989. Compartmental models of complex neurons. In: Koch, C., Segev, I. (Eds.), Methods in Neuronal Modeling. From Synapses to Network. Bradford Book. MIT Press, Cambridge, MA, pp. 63-96.
25. Storace M., Bove M., Grattarola M., Parodi M. Simulations of the behavior of synaptically driven neurons via time-invariant circuit models. IEEE Trans. Biomed. Eng. 44:1997;1282-1287.
26. Vassanelli S., Fromherz P. Transistor-records of excitable neurons from rat brain. Appl. Phys. A. 66:1998;459-463.
27. Vassanelli S., Fromherz P. Transistor probes local potassium conductances in the adhesion region of cultured rat hippocampal neurons. J. Neurosci. 19(16):1999;6767-6773.
28. Yates D.E., Levine S., Healy T.W. Site-binding model of the electrical double layer at the oxide/water interface. J. Chem. Soc. Faraday Trans. 70:1974;1807-1818.
29. Zeck G., Fromherz P. Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip. Proc. Natl. Acad. Sci. U.S.A. 98:2001;10457-10462.