Leg Blood Flow and V̇O2 during Peak Cycle Exercise in Younger and Older Women

Medicine and Science in Sports and Exercise

Volumn 36, Issue 4, 2004, Pages 623-631

  Proctor, David N ^a   Koch, Dennis W ^a   Newcomer, Sean C ^a   Le, Khoi U ^a   Smithmyer, Sandra L ^a   Leuenberger, Urs A ^a,b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; Cardiac output; Oxygen extraction; Sex; Vasodilation

Indexed keywords

LACTIC ACID;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BLOOD FLOW VELOCITY; BODY COMPOSITION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYCLING; ENDURANCE; EXTRACTION; FEMALE; FEMORAL VEIN; HEART OUTPUT; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; LACTATE BLOOD LEVEL; LEG BLOOD FLOW; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; OXYGEN BLOOD LEVEL; OXYGEN CONSUMPTION; THERMODILUTION;

ADULT; AGE FACTORS; AGED; AGING; ANAEROBIC THRESHOLD; CARDIAC OUTPUT; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; LEG; MIDDLE AGED; OXYGEN CONSUMPTION; PENNSYLVANIA; PHYSICAL FITNESS; PULMONARY GAS EXCHANGE; REGIONAL BLOOD FLOW;

EID: 1842557846     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1249/01.MSS.0000121951.10417.B5     Document Type: Article

References (34)

1. AMERICAN COLLEGE OF SPORTS MEDICINE. ACSM's Guidelines for Exercise Testing and Prescription, 6th Ed. Philadelphia: Lippincott Williams & Wilkins, 2000
2. ANDERSEN, P., and B. SALTIN. Maximal perfusion of skeletal muscle in man. J. Physiol. 366:233-249, 1985.
3. BELL, C., K. D. MONAHAN, A. J. DONATO, B. E. HUNT, D. R. SEALS, and K. C. BECK. Use of acetylene breathing to determine cardiac output in young and older adults. Med. Sci. Sports Exerc. 35:58-64, 2003.
4. BINDER, E. F., S. J. BIRGE, R. SPINA, et al. Peak aerobic power is an important component of physical performance in older women. J. Gerontol. A Biol. Sci. Med. Sci. 54:M353-M356, 1999.
5. BLAIR, S. N., H. W. KOHL, 3rd, R. S. PAFFENBARGER, Jr., D. G. CLARK, K. H. COOPER, and L. W. GIBBONS. Physical fitness and all-cause mortality: a prospective study of healthy men and women. JAMA 262:2395-2401, 1989.
6. CELERMAJER, D. S., K. E. SORENSEN, D. J. SPIEGELHALTER, D. GEORGAKOPOULOS, J. ROBINSON, and J. E. DEANFIELD. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J. Am. Coll. Cardiol. 24:471-476, 1994.
7. COBB, F. R., M. J. SULLIVAN, M. B. HIGGINBOTHAM, and D. KITZMAN. Aging: can the effects be prevented? In: Exercise and Circulation in Health and Disease, B. Saltin, R. Boushel, N. Secher, and J. Mitchell (Eds.). Champaign, IL: Human Kinetics, 2000, pp. 245-256.
8. COGGAN, A. R., R. J. SPINA, D. S. KING, et al. Histochemical and enzymatic comparison of the gastrocnemius muscle of young and elderly men and women. J. Gerontol. 47:B71-B76, 1992.
9. CONLEY, K. E., S. A. JUBRIAS, and P. C. ESSELMAN. Oxidative capacity and ageing in human muscle. J. Physiol. 526(Pt. 1):203-210, 2000.
10. COOK, J. J., T. D. WAILGUM, U. S. VASTHARE, H. N. MAYROVITZ, and R. F. TUMA. Age-related alterations in the arterial microvasculature of skeletal muscle. J. Gerontol. 47:B83-B88, 1992.
11. FITZGERALD, M. D., H. TANAKA, Z. V. TRAN, and D. R. SEALS. Age-related declines in maximal aerobic capacity in regularly exercising vs. sedentary women: a meta-analysis. J. Appl. Physiol. 83:160-165, 1997.
12. FLEG, J. L., F. O'CONNOR, G. GERSTENBLITH, et al. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J. Appl. Physiol. 78:890-900, 1995.
13. HOSSACK, K. F., F. KUSUMI, and R. A. BRUCE. Approximate normal standards of maximal cardiac output during upright exercise in women. Am. J. Cardiol. 47:1080-1086, 1981.
14. JANSSEN, I., S. B. HEYMSFIELD, Z. M. WANG, and R. ROSS. Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J. Appl. Physiol. 89:81-88, 2000.
15. MAEDA, S., T. TANABE, T. MIYAUCHI, et al. Aerobic exercise training reduces plasma endothelin-1 concentration in older women. J. Appl. Physiol. 95:336-341, 2003.
16. MARTIN, W. H., 3rd, T. OGAWA, W. M. KOHRT, et al. Effects of aging, gender, and physical training on peripheral vascular function. Circulation 84:654-664, 1991.
17. MCCOLE, S. D., M. D. BROWN, G. E. MOORE, J. M. ZMUDA, J. D. CWYNAR, and J. M. HAGBERG. Cardiovascular hemodynamics with increasing exercise intensities in postmenopausal women. J. Appl. Physiol. 87:2334-2340, 1999.
18. MOREAU, K. L., A. J. DONATO, H. TANAKA, P. P. JONES, P. E. GATES, and D. R. SEALS. Basal leg blood flow in healthy women is related to age and hormone replacement therapy status. J. Physiol. 547: 309-316, 2003.
19. MULLER-DELP, J., S. A. SPIER, M. W. RAMSEY, et al. Effects of aging on vasoconstrictor and mechanical properties of rat skeletal muscle arterioles. Am. J. Physiol. Heart Circ. Physiol. 282: H1843-H1854, 2002.
20. MULLER-DELP, J. M., S. A. SPIER, M. W. RAMSEY, and M. D. DELP. Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles. Am. J. Physiol. Heart Circ. Physiol. 283: H1662-H1672, 2002.
21. OGAWA, T., R. J. SPINA, W. H. MARTIN, 3rd, et al. Effects of aging, sex, and physical training on cardiovascular responses to exercise. Circulation 86:494-503, 1992.
22. 2 relationships during submaximal cycle ergometry. J. Appl. Physiol. 84:599-605, 1998.
23. PROCTOR, D. N., and M. J. JOYNER. Skeletal muscle mass and the reduction of VO2max in trained older subjects. J. Appl. Physiol. 82:1411-1415, 1997.
24. PROCTOR, D. N., D. W. KOCH, S. C. NEWCOMER, K. U. LE, and U. A. LEUENBERGER. Impaired leg vasodilation during dynamic exercise in healthy older women. J. Appl. Physiol. 95:1963-1970, 2003.
25. PROCTOR, D. N., S. C. NEWCOMER, D. W. KOCH, K. U. LE, D. A. MACLEAN, and U. A. LEUENBERGER. Leg blood flow during submaximal cycle ergometry is not reduced in healthy older normally active men. J. Appl. Physiol. 94:1859-1869, 2003.
26. RADEGRAN, G., and B. SALTIN. Human femoral artery diameter in relation to knee extensor muscle mass, peak blood flow, and oxygen uptake. Am. J. Physiol. Heart Circ. Physiol. 278:H162-H 167, 2000.
27. SEALS, D. R., and M. D. ESLER. Human ageing and the sympathoadrenal system. J. Physiol. 528:407-417, 2000.
28. SHIH, R., Z. WANG, M. HEO, W. WANG, and S. B. HEYMSFIELD. Lower limb skeletal muscle mass: development of dual-energy X-ray absorptiometry prediction model. J. Appl. Physiol. 89:1380-1386, 2000.
29. SNELL, P. G., W. H. MARTIN, J. C. BUCKEY, and C. G. BLOMQVIST. Maximal vascular leg conductance in trained and untrained men. J. Appl. Physiol. 62:606-610, 1987.
30. SPINA, R. J., T. OGAWA, W. H. MARTIN, 3rd, A. R. COGGAN, J. O. HOLLOSZY, and A. A. EHSANI. Exercise training prevents decline in stroke volume during exercise in young healthy subjects. J. Appl. Physiol. 72:2458-2462, 1992.
31. STARLING, R. D., M. J. TOTH, W. H. CARPENTER, D. E. MATTHEWS, and E. T. POEHLMAN. Energy requirements and physical activity in free-living older women and men: a doubly labeled water study. J. Appl. Physiol. 85:1063-1069, 1998.
32. STRANDELL, T. Cardiac output in old age. In: Cardiology in Old Age, F. I. Caird, J. L. C. Dall, and R. D. Kennedy (Eds.). New York: Plenum Press, 1976, pp. 81-100.
33. TRIEBWASSER, J. H., R. L. JOHNSON, R. P. BURPO, J. C. CAMPBELL, W. C. REARDON, and C. G. BLOMQVIST. Noninvasive determination of cardiac output by a modified acetylene rebreathing procedure utilizing mass spectrometer measurements. Aviat. Space Environ. Med. 48:203-209, 1977.
34. VAN PELT, R. E., K. P. DAVY, E. T. STEVENSON, et al. Smaller differences in total and regional adiposity with age in women who regularly perform endurance exercise. Am. J. Physiol. 275:E626-E634, 1998.