Expression of estrogen receptor α and β in the uterus and vagina of immature rats treated with 17-ethinyl estradiol

Journal of Veterinary Medical Science

Volumn 65, Issue 12, 2003, Pages 1293-1297

  Kang, Tin Seok ^a   Lee, Beom Jun ^b   Ahn, Byeongwoo ^b   Kim, Dae Joong ^b   Nam, Sang Yoon ^b   Yun, Young Won ^b   Nam, Ki Taek ^a   Choi, Mina ^a   Kim, Hyung Sik ^a   Jang, Dong Deuk ^a   Lee, Yong Soon ^c   Yang, Ki Hwa ^a  

^a Korea Food and Drug Administration   (South Korea)

^b Chungbuk National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

17 ethinyl estradiol; Estrogen receptor and ; Uterus; Vagina

Indexed keywords

ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ETHINYLESTRADIOL; MESSENGER RNA;

ANIMAL; ARTICLE; BODY WEIGHT; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HISTOLOGY; ORGAN SIZE; PHYSIOLOGY; RAT; SEXUAL MATURATION; SPRAGUE DAWLEY RAT; UTERUS; VAGINA;

ANIMALS; BODY WEIGHT; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ETHINYL ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RNA, MESSENGER; SEXUAL MATURATION; UTERUS; VAGINA;

EID: 1842556420     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.65.1293     Document Type: Article

References (22)

1. Alarid, E. T., Bakopoulos, N. and Solodin, N. 1999. Proteasome-mediated proteolysis of estrogen receptor: a novel component in autologous down-regulation. Mol. Endocrinol. 13: 1522-1534.
2. Archer, D. F. 1999. Endometrial histology during use of a low-dose estrogen-desogestrel oral contraceptive with a reduced hormone-free interval. Contraception 60: 151-154.
3. Branham, W. S., Lyn-Cook, B. D., Andrews, A. and Sheehan, D. M. 1993. Growth of separated and recombined neonatal rat uterine luminal epithelium and stroma on extracellular matrix: effects of in vivo tamoxifen exposure. In Vitro Cell Dev. Biol. Anim. 29A: 408-414.
4. Cotroneo, M. S., Wang, J., Eltoum, I. A. and Lamartiniere, C. A. 2001. Sex steroid receptor regulation by genistein in the pre-pubertal rat uterus. Mol. Cell Endocrinol. 173: 135-145.
5. Davis, D. L. and Bradlow, H. L. 1995. Can environmental estrogens cause breast cancer? Sci. Am. 273: 167-172.
6. Diel, P., Schulz, T., Smolnikar, K., Strunck, E., Vollmer, G. and Michna, H. 2000. Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity. J. Steroid Biochem. Mol. Biol. 73: 1-10.
7. Endrikat, J., Dusterberg, B., Ruebig, A., Gerlinger, C. and Strowitzki, T. 1999. Comparison of efficacy, cycle control, and tolerability of two low-dose oral contraceptives in a multicenter clinical study. Contraception 60: 269-274.
8. Enmark, E., Pelto-Huikko, M., Grandien, K., Lagercrantz, S., Lagercrantz, J., Fried, G., Nordenskjold, M. and Gustafsson, J. A. 1997. Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J. Clin. Endocrinol. Metab. 82: 4258-4265.
9. Gustafsson, J. A. 2000. Novel aspects of estrogen action. J. Soc. Gynecol. Investig. 7: S8-S9.
10. Kaunitz, A. M. 1999. Oral contraceptive health benefits: perception versus reality. Contraception 59: 29S-33S.
11. Kuiper, G. G., Enmark, E., Pelto-Huikko, M., Nilsson, S. and Gustafsson, J. A. 1996. Cloning of a novel receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. U.S.A. 93: 5925-5930.
12. Kupfer, D. 1987. Critical evaluation of methods for detection and assessment of estrogenic compounds in mammals: strengths and limitations for application to risk assessment. Reprod. Toxicol. 1. 147-153.
13. Lubahn, D. B., Moyer, J. S., Golding, T. S., Couse, J. F., Korach, K. S. and Smithies, O. 1993. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc. Natl. Acad. Sci. U.S.A. 90: 11162-11166.
14. McCormack, S. A. and Glasser, S. R. 1980. Differential response of individual uterine cell types from immature rats treated with estradiol. Endocrinology 106: 1634-1649.
15. Parczyk, K., Madjno, R., Michna, H., Nishino, Y. and Schneider, M. R. 1997. Progesterone receptor repression by estrogens in rat uterine epithelial cells. J. Steroid Biochem. Mol. Biol. 63: 309-316.
16. Saunders, P. T., Maguire, S. M., Gaughan, J. and Millar, M. R. 1997. Expression of oestrogen receptor beta (ER beta) in multiple rat tissues visualised by immunohistochemistry. J. Endocrinol. 154: R13-R16.
17. Shupnik, M. A., Gordon, M. S. and Chin, W. W. 1989. Tissue-specific regulation of rat estrogen receptor mRNAs. Mol. Endocrinol. 3: 660-665.
18. Taylor, A. H. and Al Azzawi, F. 2000. Immunolocalisation of oestrogen receptor beta in human tissues. J. Mol. Endocrinol. 24: 145-155.
19. Tremblay, G. B., Tremblay, A., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Labrie, F. and Giguere, V. 1997. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol. Endocrinol. 11: 353-365.
20. Weihua, Z., Saji, S., Makinen, S., Cheng, G., Jensen, E. V., Warner, M. and Gustafsson, J. A. 2000. Estrogen receptor (ER) beta, a modulator of ERalpha in the uterus. Proc. Natl. Acad. Sci. U.S.A. 97: 5936-5941.
21. Yang, J., Nakagawa, H., Tsuta, K. and Tsubura, A. 2000. Influence of perinatal genistein exposure on the development of MNU- induced mammary carcinoma in female Sprague-Dawley rats. Cancer Lett. 149: 171-179.
22. Zhou, Y., Chorich, L. P., Mahesh, V. B. and Ogle, T. F. 1993. Regulation of estrogen receptor protein and messenger ribonucleic acid by estradiol and progesterone in rat uterus. J. Steroid Biochem. Mol. Biol. 46: 687-698.