Off-pump CABG reduces complement activation but does not significantly affect peripheral endothelial function: A prospective randomized study

Scandinavian Cardiovascular Journal

Volumn 38, Issue 1, 2004, Pages 53-58

  Johansson Synnergren, Mats ^a   Nilsson, Folke ^a   Bengtsson, Anders ^a   Jeppsson, Anders ^a   Wiklund, Lars ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

CABG; Endothelial function; Inflammatory response; OPCAB

Indexed keywords

ACETYLCHOLINE; COMPLEMENT COMPONENT C3A; CYTOKINE; ENDOTHELIN 1; INTERLEUKIN 8; NEOPTERIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CARDIOPULMONARY BYPASS; CARDIOVASCULAR FUNCTION; COMPLEMENT ACTIVATION; COMPLEMENT BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE RELEASE; ELECTIVE SURGERY; FEMALE; FOREARM; HUMAN; MAJOR CLINICAL STUDY; MALE; OFF PUMP CORONARY SURGERY; PLETHYSMOGRAPHY; POSTOPERATIVE INFLAMMATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZATION; STATISTICAL SIGNIFICANCE; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; AREA UNDER CURVE; BIOLOGICAL MARKERS; CARDIOPULMONARY BYPASS; COMPLEMENT ACTIVATION; COMPLEMENT C3A; CORONARY ARTERY BYPASS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; FEMALE; FOREARM; HUMANS; INTERLEUKIN-8; MALE; MIDDLE AGED; NEOPTERIN; NITROPRUSSIDE; PROSPECTIVE STUDIES; REGIONAL BLOOD FLOW; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA; VASODILATION; VASODILATOR AGENTS;

EID: 1842535395     PISSN: 14017431     EISSN: None     Source Type: Journal    
DOI: 10.1080/14017430410024847     Document Type: Article

References (30)

1. Moat NE, Shore DF, Evans TW. Organ dysfunction and cardiopulmonary bypass. Eur J Cardiothorac Surg 1993; 7: 563-573.
2. Kirklin JK, Westaby S, Blackstone EH, Kirklin JW, Chenoweth DE, Pacifico AD. Complement and the damaging effects of cardiopulmonary bypass. J Thorac Cardiovasc Surg 1983; 86: 845-857.
3. Frering B, Philip I, Dehoux M, Rolland C, Langlois JM, Desmonts JM. Circulating cytokines in patients undergoing normothermic cardiopulmonary bypass. J Thorac Cardiovasc Surg 1994; 108: 636-641.
4. Kestin AS, Valeri CR, Khuri SF, et al. The platelet function defect of cardiopulmonary bypass. Blood 1993; 82: 107-117.
5. Sellke FW, Boyle EM, Jr, Verrier ED. Endothelial cell injury in cardiovascular surgery: The pathophysiology of vasomotor dysfunction. Ann Thorac Surg 1996; 62: 1222-1228.
6. Cavarocchi NC, England MD, Scaff HV, et al. Oxygen free radical generation during cardiopulmonary bypass. Circulation 1986; 74 Suppl: III130-III133.
7. Khuri SF, Valeri CR, Loscalzo J, et al. Heparin causes platelet dysfunction and induces fibrinolysis before cardiopulmonary bypass. Ann Thorac Surg 1995; 60: 1008-1014.
8. Buffolo E, de Andrade JCS, Branco JNR, Teles CA, Aguiar LF, Gomes WJ. Coronary artery bypass grafting without cardiopulmonary bypass. Ann Thorac Surg 1996; 61: 63-66.
9. Wiklund L, Johansson M, Bugge M, Rådberg G, Brandrup-Wognsen G, Berglin E. Early outcome and graft patency in mammary artery grafting of left anterior descending artery with sternotomy or anterior minithoracotomy. Ann Thorac Surg 2000; 70: 79-83.
10. Poirier NC, Carrier M, Lesperance J, et al. Quantitative angiographic assessment of coronary anastomoses performed without cardiopulmonary bypass. J Thorac Cardiovasc Surg 1999; 117: 292-297.
11. Cleveland JC, Shroyer ALW, Chen AY, Peterson E, Grover FL. Off-pump coronary artery bypass grafting decreases risk-adjusted mortality and morbidity. Ann Thorac Surg 2001; 72: 1282-1289.
12. Magee MJ, Jablonski KA, Stamou SC, et al. Elimination of cardiopulmonary bypass improves early survival for multivessel coronary artery bypass patients. Ann Thorac Surg 2002; 73: 1196-1203.
13. Angelini GD, Taylor FC, Reeves BC, Ascione R. Early and midterm outcome after off-pump and on-pump surgery in beating heart against cardioplegic arrest studies (BHACAS 1 and 2): A pooled analysis of two randomized controlled trials. Lancet 2002; 359: 1194-1199.
14. van Dijk D, Nierich AP, Jansen EWL, et al. Early outcome after off-pump versus on-pump coronary bypass surgery. Circulation 2001; 104: 1761-1766.
15. Fransen E, Maessen J, Dentener M, Senden N, Geskes G, Buurman W. Systemic inflammation present in patients undergoing CABG without extracorporeal circulation. Chest 1998; 113: 1290-1295.
16. Gulielmos V, Menschikowski M, Dill H, et al. Interleukin-1, interleukin-6 and myocardial enzyme response after coronary artery bypass grafting - a prospective randomized comparison of the conventional and three minimally invasive surgical techniques. Eur J Cardiothorac Surg 2000; 18: 594-601.
17. Brasil LA, Gomes WJ, Salomao R, Buffolo E. Inflammatory response after myocardial revascularization with or without cardiopulmonary bypass. Ann Thorac Surg 1998; 66: 56-59.
18. Ascione R, Lloyd CL, Underwood MJ, Lotto AA, Pitsis AA, Angelini GD. Inflammatory response after coronary revascularization with or without cardiopulmonary bypass. Ann Thorac Surg 2000; 69: 1198-1204.
19. Wiklund L, Johansson M, Brandrup-Wognsen G, Bugge M, Radberg G, Berglin E. Difficulties in the interpretation of coronary angiogram early after coronary artery bypass surgery on the beating heart. Eur J Cardiothorac Surg 2000; 17: 46-51.
20. Lindholm L, Bengtsson A, Hansdottir V, Lundquist M, Rosengren L, Jeppsson A. Regional oxygenation and systemic inflammatory response during cardiopulmonary bypass: Influence of temperature and blood flow variations. J Cardiothorac Vasc Anesth.: In press 2004.
21. Whitney RJ. The measurements of volume changes in human limbs. J Physiol 1953; 121: 1-27.
22. Diegeler A, Doll N, Rauch T, et al. Humoral immune response during coronary artery bypass grafting: A comparison of limited approach, "oFT-pump" technique, and conventional cardiopulmonary bypass. Circulation 2000; 102 Suppl 3: III95-III100.
23. del Balzo UH, Levi R, Polley MJ. Cardiac dysfunction caused by purified C3a anaphylatoxin. Proc Natl Sci USA 1985; 82: 886-890.
24. Wan S, Izzat MB, Lee TW, Wan IY, Tang NL, Yim AP. Avoiding cardiopulmonary bypass in multivessel CABG reduces cytokine response and myocardial injury. Ann Thorac Surg 1999; 68: 52-57.
25. de Haan J, Boonstra PW, Tabuchi N, van Oeveren W, Elbes T. Retransfusion of thoracic wound blood during heart surgery obscures biocompatibility of the extracorporeal circuit. J Thorac Cardiovasc Surg 1996; 111: 272-275.
26. Cale A, Ricagna F, Wiklund L, McGregor C, Miller V. Mononuclear cells from dogs with acute lung allograft rejection cause contraction of pulmonary arteries. Circulation 1994; 90: 952-958.
27. Angdin M, Settergren G, Waage J. Better preserved pulmonary endothelium-dependent vasodilatation with off-pump coronary surgery. Scand Cardiovasc J 2001; 35: 226-227.
28. Vanhoutte PM, Rubanyi GM, Miller VM, Houston DS. Modulation of vascular smooth muscle contraction by the endothelium. Annu Rev Physiol 1986; 48: 307-320.
29. Korn RL, Fisher CA, Livingstone ER, et al. The effects of Carmeda Bioactive Surface on human blood components during simulated extracorporeal circulation. J Thorac Cardiovasc Surg 1996; 111: 1073-1084.
30. Czerny M, Baumer H, Kilo, et al. Inflammatory response and myocardial injury following coronary artery bypass grafting with or without cardiopulmonary bypass. Eur J Cardiothorac Surg 2000; 17: 737-742.