Analysis of Solution Nonideality of a Pseudomorphic Drug System Through a Comprehensive Thermodynamic Framework for the Design of a Crystallization Process

Journal of Pharmaceutical Sciences

Volumn 93, Issue 4, 2004, Pages 995-1004

  Nordstrom, Fredrik L ^a   Rasmuson, Ake ^a   Sheikh, Ahmad Y ^b  

^a ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^b PFIZER INC   (United States)

Author keywords

Enthalpy entropy compensation; Pseudopolymorphism; Solubility; Van't Hoff plots

Indexed keywords

3,5 DICHLORO 2 HYDROXY [[2 [[[3 HYDROXY 5 [(1,4,5,6 TETRAHYDRO 5 HYDROXYPYRIMIDIN 2 YL)AMINO]PHENYL]CARBONYL]AMINO]ACETYL]AMINO]BENZENEPROPANOIC ACID; ACETONITRILE; ALPHA5BETA3 INTEGRIN ANTAGONIST; INTEGRIN; INTEGRIN ANTAGONIST; RECEPTOR BLOCKING AGENT; SOLVENT; UNCLASSIFIED DRUG; WATER;

ARTICLE; CRYSTALLIZATION; DRUG SOLUBILITY; DRUG SOLUTION; ENTHALPY; ENTROPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHASE TRANSITION; QUANTITATIVE ANALYSIS; SOLUBILIZATION; STRUCTURE ANALYSIS; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

EID: 1842534343     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10592     Document Type: Article

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