Cytomegalovirus viral load monitoring after allogeneic bone marrow transplantation in patients receiving antiviral prophylaxis

Bone Marrow Transplantation

Volumn 32, Issue 8, 2003, Pages 795-800

  Howden, Benjamin P ^a,b   Michaelides, A ^a   Spelman, D W ^a   Spencer, A ^a   Schwarer, A P ^a   Wesselingh, S ^a   Kotsimbos, T C ^a  

^a ALFRED HOSPITAL   (Australia)

^b AUSTIN HEALTH   (Australia)

Author keywords

Cytomegalovirus; Viral load

Indexed keywords

ANTIVIRUS AGENT; CYCLOPHOSPHAMIDE; CYCLOSPORIN; FLUDARABINE; GANCICLOVIR; THYMOCYTE ANTIBODY; VALACICLOVIR;

ACUTE LEUKEMIA; ADOLESCENT; ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CHRONIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; FEMALE; GRAFT VERSUS HOST REACTION; HERPES SIMPLEX; HUMAN; MALE; MEASUREMENT; NONHODGKIN LYMPHOMA; PATIENT MONITORING; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECIPIENT; SERODIAGNOSIS; STANDARDIZATION; VIRUS DETECTION; VIRUS LOAD;

ACUTE DISEASE; ADOLESCENT; ADULT; ANTIVIRAL AGENTS; BONE MARROW TRANSPLANTATION; CHRONIC DISEASE; CYTOMEGALOVIRUS INFECTIONS; FEMALE; FOLLOW-UP STUDIES; GANCICLOVIR; GRAFT VS HOST DISEASE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; VIRAL LOAD;

EID: 1842534037     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1704230     Document Type: Article

References (14)

1. Einsele H, Hebart H. Cytomegalovirus infection following stem cell transplantation. Haematologica 1999; 84 (Suppl. EHA-4): 46-49.
2. Enright H, Haake R, Weisdorf D et al. Cytomegalovirus pneumonia after bone marrow transplantation. Risk factors and response to therapy. Transplantation 1993; 55: 1339-1346.
3. Miller W, Flynn P, McCullough J et al. Cytomegalovirus infection after bone marrow transplantation: An association with acute graft-v-host disease. Blood 1986; 67: 1162-1167.
4. Machida U, Kami M, Fukui T et al. Real-time automated PCR for early diagnosis and monitoring of cytomegalovirus infection after bone marrow transplantation. J Clin Microbiol 2000; 38: 2536-2542.
5. Gor D, Sabin C, Prentice HG et al. Longitudinal fluctuations in cytomegalovirus load in bone marrow transplant patients: Relationship between peak virus load, donor/recipient sero-status, acute GVHD and CMV disease. Bone Marrow Transplant 1998; 21: 597-605.
6. Emery VC, Sabin CA, Cope AV et al. Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation. Lancet 2000; 355: 2032-2036.
7. Qamruddin AO, Oppenheim BA, Guiver M et al. Screening for cytomegalovirus (CMV) infection in allogeneic bone marrow transplantation using a quantitative whole blood polymerase chain reaction (PCR) method: analysis of potential risk factors for CMV infection. Bone Marrow Transplant 2001; 27: 301-306.
8. Boeckh M. Current antiviral strategies for controlling cytomegalovirus in hematopoietic stem cell transplant recipients: prevention and therapy. Transplant Infect Dis 1999; 1: 165-178.
9. Przepiorka D, Weisdorf D, Martin P et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant 1995; 15: 825-828.
10. Ljungman P, Plotkin SA. Workshop of CMV disease: Definitions, clinical severity scores and syndromes. Scand J Infect Dis-Suppl 1995; 99: 87-89.
11. Humar A, O'Rourke K, Lipton J et al. The clinical utility of CMV surveillance cultures and antigenemia following bone marrow transplantation. Bone Marrow Transplant 1999; 23: 45-51.
12. Ljungman P, Aschan J, Lewensohn-Fuchs I et al. Results of different strategies for reducing cytomegalovirus-associated mortality in allogeneic stem cell transplant recipients. Transplantation 1998; 66: 1330-1334.
13. Michaelides A, Liolios L, Glare EM et al. Increased human cytomegalovirus (HCMV) DNA load in peripheral blood leukocytes after lung transplantation correlates with HCMV pneumonitis. Transplantation 2001; 72: 141-147.
14. Grob JP, Grundy JE, Prentice HG et al. Immune donors can protect marrow transplant recipients from severe cytomegalovirus infections. Lancet 1987: 1: 774-776.