EPR Oximetry in the Beating Heart: Myocardial Oxygen Consumption Rate as an Index of Postischemic Recovery

Magnetic Resonance in Medicine

Volumn 51, Issue 4, 2004, Pages 835-842

  Ilangovan, Govindasamy ^a,b   Liebgott, Thibaut ^a   Kutala, Vijay Kumar ^a   Petryakov, Sergey ^a   Zweier, Jay L ^a   Kuppusamy, Periannan ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b TMRF   (United States)

Author keywords

EPR; Ischemia reperfusion; LiPc; Myocardial oxygen measurements; Oximetry; Rat heart

Indexed keywords

ELECTRON SPIN RESONANCE SPECTROSCOPY; HEART; MICROCRYSTALS; OXYGEN; OXYGENATION; RATS; RECOVERY;

ISCHEMIA REPERFUSION; LIPC; OXIMETRY; OXYGEN MEASUREMENTS; RAT HEART;

PARAMAGNETIC RESONANCE;

LITHIUM DERIVATIVE; PHTHALOCYANINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONVALESCENCE; ELECTRON SPIN RESONANCE; HEART BEAT; HEART MUSCLE CONTRACTILITY; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE PERFUSION; HEART MUSCLE REPERFUSION; HEMODYNAMICS; ISOLATED HEART; MALE; NONHUMAN; OXIMETRY; OXYGEN TISSUE LEVEL; PATHOPHYSIOLOGY; RAT; RELIABILITY; REPERFUSION INJURY;

EID: 1842533391     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.20000     Document Type: Article

References (25)

1. Mason RP, Jeffrey FM, Malloy CR, Babcock EE, Antich PP. A noninvasive assessment of myocardial oxygen tension: 19F NMR spectroscopy of sequestered perfluorocarbon emulsion. Magn Reson Med 1992;27: 310-317.
2. Shukla HP, Mason RP, Bansal N, Antich PP. Regional myocardial oxygen tension: 19F MRI of sequestered perfluorocarbon. Magn Reson Med 1996;35:827-833.
3. Zweier JL, Chzhan M, Ewert U, Schneider G, Kuppusamy P. Development of a highly sensitive probe for measuring oxygen in biological tissues. J Magn Reson B 1994;105:52-57.
4. Friedman BJ, Grinberg OY, Grinberg SA, Swartz HM. Myocardial oxygen tension in isolated erythrocyte-perfused rat hearts and comparison with crystalloid media. J Mol Cell Cardiol 1997;29:2855-2858.
5. Friedman BJ, Grinberg OY, Isaacs KA, Ruuge EK, Swartz HM. Effect of repetitive ischemia on myocardial oxygen tension in isolated perfused and hypoperfused rat hearts. Magn Reson Med 1996;35:214-220.
6. Friedman BJ, Grinberg OY, Isaacs KA, Walczak TM, Swartz HM. Myocardial oxygen tension and relative capillary density in isolated perfused rat hearts. J Mol Cell Cardiol 1995;27:2551-2558.
7. Swartz HM, Glockner JF. Measurement of oxygen by EPRI and EPRS In: Eaton GRE SS, Ohno K, editors. EPR imaging and in vivo EPR. Boca Raton, FL: CRC Press; 1991.
8. Hirata H, Walczak T, Swartz HM. Electronically tunable surface-coil-type resonator for L-band EPR spectroscopy. J Magn Reson 2000;142: 159-167.
9. Ilangovan G, Zweier JL, Kuppusamy P. Electrochemical preparation and EPR studies of lithium phthalocyanine: evaluation of the nucleation and growth mechanism and evidence for potential dependent phase formation. J Phys Chem B 2000;104:4047-4059.
10. Ilangovan G, Zweier JL, Kuppusamy P. Electrochemical preparation and EPR studies of lithium phthalocyanine. 2. Particle size-dependent line broadening by molecular oxygen and its implications as an oximetry probe. J Phys Chem B 2000;104:9404-9410.
11. Ilangovan G, Li H, Zweier JL, Kuppusamy P. Electrochemical preparation and EPR studies of lithium phthalocyanine. 3. Measurement of oxygen concentration in tissues and biochemical reactions. J Phys Chem B 2001;105:5323-5330.
12. Ilangovan G, Zweier JL, Kuppusamy P. Electrochemical preparation and EPR studies of lithium phthalocyanine microcrystals. 4. Adsorption of molecular oxygen. J Phys Chem B 2004 (submitted).
13. Ilangovan G, Li H, Zweier JL, Kuppusamy P. In vivo measurement of tumor redox environment using EPR spectroscopy. J Mol Cell Biochem 2002;234/235:393-398.
14. Ilangovan G, Li H, Zweier JL, Krishna MC, Mitchell JB, Kuppusamy P. In vivo measurement of regional oxygenation and imaging of redox status in RIF-1 murine tumor: effect of carbogen-breathing. Magn Reson Med 2002;48:723-730.
15. Liu KJ, Gast P, Moussavi M, Norby SW, Vahidi N, Walczak T, Wu M, Swartz HM. Lithium phthalocyanine: a probe for electron paramagnetic resonance oximetry in viable biological systems. Proc Natl Acad Sci USA 1993;90:5438-5442.
16. Chzhan M, Kuppusamy P, Zweier JL. Development of an electronically tunable L-band resonator for EPR spectroscopy and imaging of biological samples. J Magn Reson B 1995;108:67-72.
17. Ono M, Ito K, Kawamura N, Hsieh KC, Hirata H, Tsuchihashi N, Kamada H. A surface-coil-type resonator for in vivo ESR measurements. J Magn Reson B 1994;104:180-182.
18. Ono M, Suenaga A, Hirata H. Experimental investigation of RF magnetic field homogeneity in a bridged loop-gap resonator. Magn Reson Med 2002;47:415-419.
19. Kuppusamy P, Chzhan M, Vij K, Shteynbuk M, Lefer DJ, Giannella E, Zweier JL. Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: a technique for imaging tissue metabolism and oxygenation. Proc Natl Acad Sci USA 1994;91:3388-3392.
20. He G, Evalappan SP, Hirata H, Deng Y, Petryakov S, Kuppusamy P, Zweier JL. Mapping of the B1 field distribution of a surface coil resonator using EPR imaging. Magn Reson Med 2002;48:1057-1062.
21. Zweier JL, Thompson-Gorman S, Kuppusamy P. Measurement of oxygen concentrations in the intact beating heart using electron paramagnetic resonance spectroscopy: a technique for measuring oxygen concentrations in situ. J Bioenerg Biomembr 1991;23:855-871.
22. Sommerschild HT, Kirkeboen KA. Preconditioning - endogenous defence mechanisms of the heart. Acta Anaesthes Scand 2002;46:123-137.
23. Askenasy N, Navon G. Continuous monitoring of intracellular volumes in isolated rat hearts during normothermic perfusion and ischemia. J Magn Reson 1997;124:42-50.
24. Shen W, Tian R, Saupe KW, Spindler M, Ingwall JS. Endogenous nitric oxide enhances coupling between O2 consumption and ATP synthesis in guinea pig hearts. Am J Physiol Heart Circ Physiol 2001;281:H838-846.
25. Zhao Y, Richman A, Storey C, Redford NB, Pantano P. In situ fiberoptic oxygen consumption measurements from a working mouse heart. Anal Chem 1999;71:3887-3893.