Is DNA polymerase β important in thermal radiosensitization?

International Journal of Hyperthermia

Volumn 20, Issue 2, 2004, Pages 140-143

  Raaphorst, G P ^a   Yang, D P ^a   Niedbala, G ^a  

^a OTTAWA REGIONAL CANCER CENTRE   (Canada)

Author keywords

DNA polymerase ; Thermal radiosensitization

Indexed keywords

DNA DIRECTED DNA POLYMERASE BETA;

ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CARCINOMA CELL; CELL STRAIN MCF 7; CONTROLLED STUDY; EXCISION REPAIR; GENETIC TRANSFECTION; HEAT SENSITIVITY; HUMAN; HUMAN CELL; HYPERTHERMIA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RADIATION INJURY; RADIOSENSITIZATION; TEMPERATURE;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DNA POLYMERASE BETA; DNA REPAIR; HUMANS; HYPERTHERMIA, INDUCED; MICE; MICE, KNOCKOUT; RADIATION TOLERANCE;

EID: 1842525168     PISSN: 02656736     EISSN: None     Source Type: Journal    
DOI: 10.1080/02656730310001597555     Document Type: Article

References (14)

1. Li GC, Evans RG, Hahn GM. Modification and inhibition of repair of potentially lethal x-ray damage by hyperthermia. Rad Res 1976; 67: 491-501.
2. Raaphorst GP, Freeman ML, Dewey WC. Radiosensitivity and recovery from radiation damage in cultured CHO cells exposed to hyperthermia at 42.5°C or 45.5°C. Rad Res 1979; 79: 390-402.
3. Raaphorst GP. Thermal radiosensitization in vitro. In: Urano M, Douple E, eds. Hyperthermia and Oncology, Vol. II, Utrecht, VSP, 1989: 17-51.
4. Wang TSF. Eukaryotic DNA polymerases. Ann Rev Biochemistry 1991; 60: 513-552.
5. Spiro IJ, Denman DL, Dewey WC. Effect of hyperthermia on isolated DNA polymerase β. Rad Research 1983; 95: 68-77.
6. Chu GL, Dewey WC. Effect of cycloheximide on heat-induced cell killing, radiosensitization and loss of cellular DNA polymerase activities in Chinese hamster ovary cells. Rad Research 1987; 112: 575-580.
7. Dikomey E, Jung H. Correlation between thermal radiosensitization and heat-induced loss of DNA polymerase β activity in CHO cells. Int J Rad Biol 1993; 2: 215-221.
8. Raaphorst GP, Feeley MM. Hyperthermia radiosensitization in human glioma cells, comparison of recovery of polymerase activity, survival and potentially lethal damage repair. Int J Rad Oncol 1994; 29: 133-139.
9. Kampinga HH, Horritsma JBM, Burgman P, Konings AWT. Differences in heat-induced cell killing as determined in three mammalian cell lines do not correspond with the extent of heat radiosensitization. Int J Rad Biol 1986; 50: 675-684.
10. Jorritsma JBM, Burgman P, Kampinga HH, Konings AWT. DNA polymerase activity in heat killing and hyperthermic radiosensitization of mammalian cells as observed after fractionated heat treatments. Rad Res 1986; 105: 307-319.
11. Sobol RW, Horton JK, Kuhn R, Gu H, Singhal RK, Prasad R, et al. Requirement of mammalian DNA polymerase β in base excision repair. Nature 1996; 379: 183-186.
12. Raaphorst GP, Cybulski S, Ng CE. The response of human breast tumour cell lines with altered polymerase β levels to cisplatin and radiation. AntiCancer Res 2001; 21: 2079-2084.
13. Raaphorst GP, Yang DP, Sobol R, Ng CE. Comparison of response to radiation, hyperthermia and cisplatin in parental and polymerase β knockout cells. Int J Hyperthermia 2002; 15: 33-39.
14. Raaphorst GP, Heller DP, Bussey A, Ng CE. Thermal radiosensitization by 41°C hyperthermia during low dose-rate irradiation in human normal and tumor cell lines. Int J Hyperthermia 1994; 10: 263-270.