The Influence of Single or Repeated Low-Level Sarin Exposure on Immune Functions of Inbred BALB/c Mice

Basic and Clinical Pharmacology and Toxicology

Volumn 94, Issue 3, 2004, Pages 139-143

  Kassa, Jiří ^a   Krocova Z ^a   Sevelova L ^a   Sheshko, V ^a   Kasalova I ^a   Neubauerova V ^a  

^a DEPARTMENT OF TOXICOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CONCANAVALIN A; LIPOPOLYSACCHARIDE; MITOGENIC AGENT; NITRIC OXIDE; ORGANOPHOSPHATE INSECTICIDE; SARIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BACTERICIDAL ACTIVITY; BLOOD; CHEMICAL WARFARE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; HELPER CELL; IMMUNOTOXICITY; IN VITRO STUDY; INBRED STRAIN; INHALATION; LUNG; LUNG ALVEOLUS MACROPHAGE; LYMPHOCYTE PROLIFERATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; SPLEEN LYMPHOCYTE; T LYMPHOCYTE;

ANIMALIA;

EID: 1842523064     PISSN: 17427835     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2004.pto940307.x     Document Type: Article

References (36)

1. Abraham, E., A. A. Freitas & A. A. Countiho: Purification and characterization of intraparenchymal lung lymphocytes. J. Immunol. 1990, 144, 2117-2122.
2. Bajgar, J.: Biological monitoring of exposure to nerve agents. Brit. J. Ind Med. 1992, 49, 648-653.
3. Casale, G. P., S. D. Cohen & R. A. DiCapua: The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice. Toxicol. Appl. Pharmacol. 1983, 68, 198-205.
4. Casale, G. P., S. D. Cohen & R. A. DiCapua: Parathion-induced suppression of humoral immunity in inbred mice. Toxicol. Lett. 1984, 23, 239-247.
5. Ellman, G. L., D. K. Courtney, V. Jr. Andres & R. N. Feartherstone: A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 1961, 7, 88-91.
6. Hermanowitz, A. & S. Kossman: Neutrophil function and infectious disease occupationally exposed to phosphoorganic pesticides: Role of mononuclear-derived chemotactic factor for neutrophils. Clin. Immunol. Immunopathol. 1984, 33, 13-22.
7. Johnson, V. J., A. M. Rosenberg, K. Lee & B. R. Blakley: Increased T-lymphocyte dependent antibody production in female SJL/J mice following exposure to commercial grade malathion. Toxicology 2002, 170, 119-129.
8. Kant, G. J., T. M. Shih, E. W. Bernton, H. G. Fein, R. C. Smallridge & E. H. Mongey: Effects of soman on neuroendocrine and immune function. Neurotoxicol. Teratol. 1991, 13, 223-228.
9. Kassa, J., Z. Kročová & J. Vachek: Long term alteration of immune functions following low level exposure to sarin in rats. Acta Med. (Hradec Králové) 2000, 43, 91-94.
10. Kassa, J., Z. Kročová, L. Ševelová, V. Shesho, I. Kasalová & V. Neubaerová: Low-level sarin-induced alteration of immune system reaction in inbred BALB/c mice. Toxicology 2003, 187, 195-203.
11. Kawashima, K. & T. Fujii: The lymphocytic cholinergic system and its biological function. Life Sci. 2003, 72, 2101-2109.
12. Li, Q., Y. Hirata, S. Piao & M. Minami: The by-products generated during sarin synthesis in the Tokyo sarin disaster induced inhibition of natural killer and cytotoxic T lymphocyte activity. Toxicology 2000, 146, 209-220.
13. Li, Q., N. Nagahara, H. Takahashi, K. Takeda & K. Okumura: Organophosphorus pesticides markedly inhibit the activities of natural killer, cytotoxic T lymphocyte and lymphocyte-activated killer: a proposed inhibiting mechanism via granzyme inhibition. Toxicology 2002, 172, 181-190.
14. Ling, N. R. & J. E. Kay: Lymphocyte stimulation. North Holland Publishing Company, 1975, p. 398.
15. Marrs, T. C.: Organophosphate poisoning. Pharmacol. Ther. 1993, 58, 51-66.
16. Midtling, J. E., P. G. Barnett & M. J. Coye: Clinical management of organophosphate poisoning. West J. Med. 1985, 142, 514-518.
17. Moncada, S., R. M. J. Palmer & A. Higgs: Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 1991, 43, 109-142.
18. Newball, H. H., M. A. Donlon, L. R. Procell, E. A. Helgeson & D.R. Franz: Organophosphate-induced histamine release from mast cells. J. Pharmacol. Exp. Therap. 1986, 238, 839-845.
19. Newcombe, D. S. & A. H. Esa: Immunotoxicity of organophosphorus compounds. In: Clinical immunotoxicology Eds.: Newcombe D. S., N. R. Rose & J. C. Bloom. New York Raven Press, 1992, pp. 349-363.
20. Ohtomi, S., M. Takase & F. Kumagai: Sarin poisoning in Japan. A clinical experience in Japan Self Defense Force (JSDF) Central Hospital. Int. Rev. Arm. For. Med. Ser. 1996, 69, 97-102.
21. Pospíšil, M., P. Drábek, J. Hofman, K. Nouza & J. Klapáčová: Effect of immunosuppressive agent on the blastogenic response of mouse spleen T and B lymphocytes. Folia Biol. 1978, 24, 185-198.
22. Pruett, S. B. & J. E. Chambers: Effects of paraoxon, p-nitrophenol, phenyl saligenin cyclic phosphate and phenol on the rat inteleukin 2 system. Toxicol. Lett. 1988, 40, 11-20.
23. Pruett, S. B., Y. Han, A. E. Munson & B. A. Fuchs: Assessment of cholinergic influences on a primary humoral immune response. Immunology 1992, 77, 428-435.
24. Queiroz, M. L. S., M. D. Fernandez & M. C. Valadaresm: Neutrophil function in workers exposed to organophosphate and carbamate insecticides. Int. J. Immunopharmacol. 1999, 21, 263-270.
25. Ray, D. E.: Chronic effects of low level exposure to anticholinesterases - a mechanistic review. Toxicol. Lett. 1998, 102-103, 527-533.
26. Samnaliev, I., K. Mladenov & P. Padechky: Investigations into the influence of multiple doses of a potent cholinesterase inhibitor on the host resistance and humoral mediated immunity in rats. Voj. zdrav. Listy 1996, 65, 143-147.
27. Sevaljevic, L., K. Krtolica, G. Poznanovic, S. Marinkovic & B. Boskovic: Soman intoxication-induced increase in the levels of mRNAs coding for acute phase reactants. Life Sci. 1987, 41, 621-627.
28. Sevaljevic, L., S. Marinkovic, D. Bogojevic, S. Matic & B. Boskovic: Soman intoxication-induced changes in serum acute phase protein levels, corticosterone concentration and immunosuppressive potency of the serum. Arch. Toxicol. 1989, 63, 406-411.
29. Sevaljevic, L., G. Poznakovic & S. Ivanovic-Matic: The acute phase of rats to soman intoxication. Toxicology 1992, 75, 1-12.
30. Schwartz, A. & E. Fernandez-Repollet: Standardization for flow cytometry. In: Methods in cell biology. Vol. 42. Academic Press, 1994, pp. 605-626.
31. Sullivan, J. B.: Immunological alterations and chemical exposure. Clin. Toxicol. 1989, 27, 311-343.
32. Tallarida, R. & R. Murray: Manual of pharmacological calculation with computer programs. Springer-Verlag, New York, 1987, p. 145.
33. Taylor, P.: Anticholinesterase agents. In: The pharmacological basis of therapeutics, 9th ed. Eds.: J. G. Hardman & L. E. Limbird. New York, McGraw Hill, 1996, pp. 161-176.
34. Treves, A. J., M. Feldman & H. S. Kaplan: Primary cultures of human spleen macrophages in vitro. J. Immunol. Methods, 1976, 13, 279-287.
35. Vitale, M.: NK function in flow cytometry. Web: http://www.cyto.purdue.edu, Purdue Cytometry CD-ROM Series, Cytometry Vol.2, Cell Function Assay (1996).
36. Wessler, I., H. Kilbinger, F. Bittinger, R. Unger & C. J. Kirkpatrick: The non-neuronal cholinergic system in humans: Expression, function and pathophysiology. Life Sci. 2003, 72, 2055-2061.