Cytomegalovirus Infection after Orthotopic Liver Transplantation Is Restricted by A Pre-Existing Antiviral Immune Response of the Recipient

Journal of Medical Virology

Volumn 73, Issue 1, 2004, Pages 45-53

  Bissinger, A L ^a,c   Oettle, H ^b   Jahn, G ^a   Neuhaus, P ^b   Sinzger, C ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c Institut fur Medizinische Virologie   (Germany)

Author keywords

Cellular immunoreaction; HCMV; Immunohistochemistry; Liver; OLT; Pathogenesis

Indexed keywords

CELL MARKER; CELL PROTEIN; CYTOMEGALOVIRUS ANTIBODY; IMMEDIATE EARLY ANTIGEN; UNCLASSIFIED DRUG; VIRUS ANTIGEN; VIRUS CAPSID ANTIGEN;

ANTIGEN DETECTION; ARTICLE; BILE DUCT; CELL NUCLEUS INCLUSION BODY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; ENDOTHELIUM CELL; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFECTION SENSITIVITY; INFLAMMATION; INFLAMMATORY INFILTRATE; LIVER BIOPSY; LIVER CELL; LIVER DYSFUNCTION; LIVER SINUSOID; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MESENCHYME CELL; ORGAN DONOR; REINFECTION; VIRUS INHIBITION; VIRUS REACTIVATION; VIRUS REPLICATION;

ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOHISTOCHEMISTRY; LIVER; LIVER TRANSPLANTATION; TISSUE DONORS; VIRUS REPLICATION;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 1842508953     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmv.20060     Document Type: Article

References (38)

1. Alford CA, Britt WJ. 1993. Cytomegalovirus. In: Roizman B, Whitley RJ, Lopez C, editors. The human herpesviruses. New York: Raven Press. pp 227-255.
2. Barkholt LM, Ehrnst A, Veress B. 1994. Clinical use of immunohistopathologic methods for the diagnosis of cytomegalovirus hepatitis in human liver allograft biopsy specimens. Scand J Gastroenterol 29:553-560.
3. Bissinger AL, Sinzger C, Kaiserling E, Jahn G. 2002a. Human cytomegalovirus as a direct pathogen: Correlation of multiorgan involvement and cell distribution with clinical and pathological findings in a case of congenital inclusion disease. J Med Virol 67:200-206.
4. Bissinger AL, Rauser G, Hebart H, Frank F, Jahn G, Einsele H. 2002b. Isolation and expansion of human cytomegalovirus-specific cytotoxic T lymphocytes using interferon-gamma secretion assay. Exp Hem 30:1178-1184.
5. Brainard JA, Greenson JK, Vesy CJ, Tesi RJ, Papp AC, Snyder PJ, Western L, Prior TW. 1994. Detection of cytomegalovirus in liver transplant biopsies. A comparison of light microscopy, immunohistochemistry, duplex PCR and nested PCR. Transplantation 57:1753-1757.
6. Bronsther O, Makowka L, Jaffe R, Demetris AJ, Breinig MK, Ho M, Esquivel CO, Gordon RD, Iwatsuki S, Tzakis A, Marsh JW, Mazzaferro V, Van Thiel D, Starzl TE. 1988. Occurrence of cytomegalovirus hepatitis in liver transplant patients. J Med Virol 24:423-434.
7. Cope AV, Sabin C, Burroughs A, Rolles K, Griffiths PD, Emery VC. 1997. Interrelationship among quantity of human cytomegalovirus (HCMV) DNA in blood, donor recipient serostatus, and administration of methylprednisolone as risk factors for HCMV disease following liver transplantation. J Infect Dis 176:1484-1490.
8. Eddleston M, Peacock S, Juniper M, Warrell DA. 1997. Severe cytomegalovirus infection in immunocompetent patients. Clin Infect Dis 24:52-56.
9. Einsele H, Waller HD, Weber P, Frickhofen N, Dette S, Horny HP, Roos A, Roos H, Hebart H, Schmidt H, Mueller CA. 1994. Cytomegalovirus in liver biopsies of marrow transplant recipients: Detection methods, clinical, histological and immunohistological features. Med Microbiol Immunol 183:205-216.
10. Einsele H, Roosnek E, Rufer N, Sinzger C, Riegler S, Loeffler J, Grigoleit GU, Moris A, Rammensee HG, Kanz L, Kleihauer A, Frank F, Jahn G, Hebart H. 2002. Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood 99:3916-3922.
11. Emery VC. 2001. Investigation of CMV disease in immunocompromised patients. J Clin Pathol 54:84-88.
12. Evans PC, Coleman N, Wreghitt TG, Wight DGD, Alexander GJM. 1999. Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts. J Hepatol 31:913-920.
13. Funato T, Satou N, Abukawa D, Satou J, Abe Y, Ishii KK, Iinuma K, Kaku M, Sasaski T. 2001. Quantitative evaluation of cytomegalovirus DNA in infantile hepatitis. J Viral Hepat 8:217-222.
14. Grundy JE, Shanley JD, Griffiths PD. 1987. Is cytomegalovirus interstitial pneumonitis in transplant recipients an immunopathological condition? Lancet 2:996-999.
15. Hebart H, Kanz L, Jahn G, Einsele H. 1998. Management of cytomegalovirus infection after solid-organ or stem-cell transplantation. Current guidelines and future prospects. Drugs 55:59-72.
16. Heson DE, Grimley PM, Strano AJ. 1974. Postnatal cytomegalovirus hepatitis. An autopsy and liver biopsy study. Human Pathol 5:96-103.
17. Klemola E, Essen Rv, Wagner O, Haltia K, Koivuniemi A, Salmi I. 1969. Cytomegalovirus mononucleosis in previously healthy individuals. Five new cases and follow-up of 13 previously published cases. Ann Intern Med 71:11-19.
18. Laskus T, Lupa E, Cianciara J, Slusarczyk J. 1990. Cytomegalovirus infection presenting as hepatitis. Digestion 47:167-171.
19. Lautenschlager I, Hockerstedt K, Jalanko H, Loginov R, Salmela K, Taskinen E, Ahonen J. 1997. Persistent cytomegalovirus in liver allografts with chronic rejection. Hepatology 25:190-194.
20. Mazeron MC, Jahn G, Plachter B. 1992. Monoclonal antibody E-13 (M-810) to human cytomegalovirus recognizes an epitope encoded by exon 2 of the major immediate early gene. J Gen Virol 73:2699-2703.
21. Olver SD, Price P, Shellam GR. 1994. Cytomegalovirus hepatitis: Characterization of the inflammatory infiltrate in resistant and susceptible mice. Clin Exp Immunol 98:375-381.
22. Paya CV, Holley KE, Wiesner RH, Balasubramaniam K, Smith TF, Espy MJ, Ludwig J, Batts KP, Hermans PE, Krom RA. 1990. Early diagnosis of cytomegalovirus hepatitis in liver transplant recipients: Role of immunostaining, DNA hybridization and culture of hepatic tissue. Hepatology 12:119-126.
23. Plachter B, Sinzger C, Jahn G. 1996. Cell types involved in replication and distribution of human cytomegalovirus. Adv Virus Res 46:195-261.
24. Podlech J, Holtappels R, Wirtz N, Steffens HP, Reddehase MJ. 1998. Reconstitution of CD8 T cells is essential for the prevention of multiple-organ cytomegalovirus histopathology after bone marrow transplantation. J Gen Virol 79:2099-2104.
25. Price P, Olver SD, Gibbons AE, Shellam GR. 1993. B-cell activation following murine cytomegalovirus infection: Implications for autoimmunity. Immunology 78:14-21.
26. Ray RA, Lewin KJ, Colonna J, Goldstein LI, Busuttil RW. 1988. The role of liver biopsy in evaluating acute allograft dysfunction following liver transplantation: A clinical histologic correlation of 34 liver transplants. Hum Pathol 19:835-848.
27. Reller LB. 1973. Granulomatous hepatitis associated with acute cytomegalovirus infection. Lancet 1:20-22.
28. Reusser P. 1991. Cytomegalovirus infection and disease after bone marrow transplantation: Epidemiology, prevention, and treatment. Bone Marrow Transplant 7s3:52-56.
29. Reusser P. 1996. The challenge of cytomegalovirus infection after bone marrow transplantation: Epidemiology, prophylaxis, and therapy. Bone Marrow Transplant 18s2:107-109.
30. Riddell SR, Greenberg PD. 2000. T-cell therapy of cytomegalovirus and human immunodeficiency virus infection. J Antimicrob Chemother 45sT3:35-43.
31. Sacks SL, Freeman HJ. 1984. Cytomegalovirus hepatitis: Evidence for direct hepatic viral infection using monoclonal antibodies. Gastroenterology 86:346-350.
32. Singh N, Dummer JS, Kusne S, Breinig MK, Armstrong JA, Makowka L, Starzl TE, Ho M. 1988. Infections with cytomegalovirus and other herpesviruses in 121 liver transplant recipients: Transmission by donated organ and the effect of OKT3 antibodies. J Infect Dis 158:124-131.
33. Sinzger C, Plachter B, Stenglein S, Jahn G. 1993. Immunohistochemical detection of viral antigens in smooth muscle, stromal, and epithelial cells from acute human cytomegalovirus gastritis. J Infect Dis 167:1427-1432.
34. Sinzger C, Grefte A, Plachter B, Gouw AS, The TH, Jahn G. 1995. Fibroblasts, epithelial cells and smooth muscle cells are major targets of human cytomegalovirus infection in lung and gastrointestinal tissues. J Gen Virol 76:741-750.
35. Sinzger C, Bissinger AL, Viebahn R, Oettle H, Radke C, Schmidt CA, Jahn G. 1999. Hepatocytes are permissive for human cytomegalovirus infection in human liver cell culture and in vivo. J Infect Dis 180:976-986.
36. Snover DC, Horwitz CA. 1984. Liver disease in cytomegalovirus mononucleosis: A light microscopical and immunoperoxidase study of six cases. Hepatology 4:408-412.
37. Stratta RJ, Shaeffer MS, Markin RS, Wood RP, Langnas AN, Reed EC, Donovan JP, Woods GL, Bradshaw KA, Pillen TJ, Shaw BW. 1992. Cytomegalovirus infection and disease after liver transplantation. An overview. Dig Dis Sci 37:673-688.
38. Ten Napel HH, Houthoff HJ, The TH. 1984. Cytomegalovirus hepatitis in normal and immune compromised hosts. Liver 4:184-194.