Autoimmune renal injury in C3- and C4-deficient mice: A histological and functional study

Nephron - Experimental Nephrology

Volumn 96, Issue 1, 2004, Pages

  Kouki, P ^a   Marsh, J E ^a   Sacks, S H ^a   Sheerin, N S ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

Autoantibodies; Autoimmunity; Complement deficiency; Glomerulonephritis; Knockout mice

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; AUTOANTIBODY; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GLOMERULUS; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; KIDNEY FUNCTION; KIDNEY INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE; AUTOIMMUNITY; COMPLEMENT DEFICIENCY; GLOMERULONEPHRITIS; IMMUNE RESPONSE; KNOCKOUT MOUSE;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; COMPLEMENT C3; COMPLEMENT C4; FEMALE; FROZEN SECTIONS; GLOMERULONEPHRITIS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOHISTOCHEMISTRY; KIDNEY GLOMERULUS; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, MUTANT STRAINS;

EID: 1842507201     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000075572     Document Type: Article

References (34)

1. Fujita T: Evolution of the lectin-complement pathway and its role in innate immunity. Nat Rev Immunol 2002;2:346-353.
2. Sahu A, Lambris JD: Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunol Rev 2001;180:35-48.
3. Prodeus AP, Zhou X, Maurer M, Galli SJ, Carroll MC: Impaired mast cell-dependent natural immunity in complement C3 deficient mice. Nature 1997;390:172-175.
4. Wessels MR, Butko P, Ma M, Warren HB, Lage AL, Carroll MC: Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. Proc Natl Acad Sci USA 1995;92:11490-11494.
5. Ochsenbein AF, Pinschewer DD, Odermatt B, Carroll MC, Hengartner H, Zinkernagel RM: Protective T cell-independent antiviral antibody responses are dependent on complement. J Exp Med 1999;190:1165-1174.
6. Spear GT, Hart M, Olinger GG, Hashemi FB, Saifuddin M: The role of the complement system in virus infections. Antibodies Viral Infect 2001;260:229-245.
7. Carroll MC, Pozdnyakova OO, Paul E, Prodeus AP, Shen L: A critical role of complement in regulation of self-reactive B cells. FASEB J 1999;13:A955.
8. Fearon DT, Carroll MC: Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu Rev Immunol 2000;18:393-422.
9. Dempsey PW, Allison ME, Akkaraju S, Goodnow CC, Fearon DT: C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity. Science 1996;271:348-350.
10. Kerekes K, Prechl J, Bajtay Z, Jozsi M, Erdei A: A further link between innate and adaptive immunity: C3 deposition on antigen-presenting cells enhances the proliferation of antigenspecific T cells. Int Immunol 1998;10:1923-1930.
11. Cornacoff JB, Hebert LA, Smead WL, Vanaman ME, Birmingham DJ, Waxman FJ: Primate erythrocyte-immune complex-clearing mechanism. J Clin Invest 1983;71:236-247.
12. Schifferli JA, Morris SM, Dash A, Peters DK: Complement-mediated solubilization in patients with systemic lupus-erythematosus, nephritis or vasculitis. Clin Exp Immunol 1981;46:557-564.
13. Schifferli JA, Woo P, Peters DK: Complementmediated inhibition of immune precipitation. 1. Role of the classical and alternative pathways. Clin Exp Immunol 1982;47:555-562.
14. Fujigaki Y, Batsford SR, Bittersuermann D, Vogt A: Complement-system promotes transfer of immune-complex across glomerular-filtration barrier. Lab Invest 1995;72:25-33.
15. Sheerin NS, Springall T, Carroll M, Sacks SH: Altered distribution of intraglomerular immune complexes in C3-deficient mice. Immunology 1999;97:393-399.
16. Botto M, Dell'Agnola C, Bygrave AE, Thompson EM, Cook HT, Petry F, Loos M, Pandolfi PP, Walport MJ: Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet 1998;19:56-59.
17. Casciolal-Rosen LA, Anhalt G, Rosen A: Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994;179:1317-1730.
18. Topaloglu R, Bakkaloglu A, Slingsby JH, Aydintug O, Besbas N, Saatci U, Walport MJ: Survey of Turkish systemic lupus erythematosus patients for a particular mutation of C1q deficiency. Clin Exp Rheumatol 2000;18:75-77.
19. Mitchell DA, Taylor PR, Cook HT, Moss J, Bygrave AE, Walport MJ, Botto M: Cutting edge: C1q protects against the development of glomerulonephritis independently of C3 activation. J Immunol 1999;162:5676-5679.
20. Taylor PR, Carugati A, Fadok VA, Cook HT, Andrews M, Carroll MC, Savill JS, Henson PM, Botto M, Walport MJ: A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J Exp Med 2000;192:359-366.
21. Chen ZB, Koralov SB, Kelsoe G: Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. J Exp Med 2000;192:1339-1351.
22. Paul E, Pozdnyakova OO, Mitchell E, Carroll MC: Anti-DNA autoreactivity in C4-deficient mice. Eur J Immunol 2002;32:2672-2679.
23. Fischer MB, Ma M, Goerg S, Zhou X, Xia J, Finco O, Han S, Kelsoe G, Howard RG, Rothstein TL, Kremmer E, Rosen FS, Carroll MC: Regulation of the B cell response to T-dependent antigens by classical pathway complement. J Immunol 1996;157:549-556.
24. Chen A, Sheu LF, Ho YS, Lin YF, Chou WY, Chou TC, Lee WH: Experimental focal segmental glomerulosclerosis in mice. Nephron 1998;78:440-452.
25. Amoura Z, Cabre H, Koutouzov S, Lotton C, Cabrespines A, Bach JF, Jacob L: Nucleosome-restricted antibodies are detected before anti-ds DNA and/or antihistone antibodies in serum of MRL-MP LPR/LPR and +/+-mice, and are present in kidney eluates of lupus mice with proteinuria. Arthritis Rheum 1994;37:1684-1688.
26. Sheerin NS, Springall T, Carroll MC, Hartley B, Sacks SH: Protection against anti-glomerular basement membrane (GBM)-mediated nephritis in C3-and C4-deficient mice. Clin Exp Immunol 1997;110:403-409.
27. Ravirajan CT, Sarraf CE, Anilkumar TV, Golding MH, Alison MR, Isenberg DA: An analysis of apoptosis in lymphoid organs and lupus disease in murine systemic lupus erythematosus (SLE). Clin Exp Immunol 1996;105:306-312.
28. Prodeus A, Goerg S, Xia JR, Ma MH, Carroll MC: Role of complement C4 in regulation of autoreactive B cells in lprlpr mice. Arthritis Rheum 1997;40:552.
29. Mitchell DA, Pickering MC, Warren J, Fossati-Jimack L, Cortes-Hernandez J, Gok HT, Botto M, Wulport MJ: C1q deficiency and autoimmunity: The effects of genetic background on disease expression. J Immunol 2002;168:2538-2543.
30. Murakami M, Nakajima K, Yamazaki K, Muraguchi T, Serikawa T, Honjo T: Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice. J Exp Med 1997;185:791-794.
31. Saravia Fernandez F, Durant S, El Hasnaoui A, Dardenne M, HomoDelarche F: Environmental and experimental procedures leading to variations in the incidence of diabetes in the nonobese diabetic (NOD) mouse. Autoimmunity 1996;24:113-121.
32. Ahearn JM, Fischer MB, Croix D, Goerg S, Ma M, Xia J, Zhou X, Howard RG, Rothstein TL, Carroll MC: Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity 1996;4:251-262.
33. Cutler AJ, Botto M, van Essen D, Rivi R, Davies KA, Gray D, Walport MJ: T cell-dependent immune response in C1q-deficient mice: Defective interferon gamma production by antigen-specific T cells. J Exp Med 1998;187:1789-1797.
34. Marsh JE, Farmer CT, Jurcevic S, Wang Y, Carroll MC, Sacks SH: The allogeneic T and B cell response is strongly dependent on complement components C3 and C4. Transplantation 1902;72:1310-1318.