Therapy for Acute Nonpurulent Rhinosinusitis with Cineole: Results of a Double-Blind, Randomized, Placebo-Controlled Trial

Laryngoscope

Volumn 114, Issue 4, 2004, Pages 738-742

  Kehrl, Wolfgang ^a,d   Sonnemann, Uwe ^b   Dethlefsen, Uwe ^c  

^a Klink/Ambulatorium F HNO Frankeiten ^*  (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c McKnight Laboratories   (Germany)

^d Marienkrankenhaus   (Germany)

Author keywords

Cineole; Mucociliary clearance; Rhinosinusitis

Indexed keywords

ANTIBIOTIC AGENT; CINEOLE; PLACEBO; C REACTIVE PROTEIN; CYCLOHEXANOL DERIVATIVE; TERPENE; TOPICAL ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC THERAPY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG CAPSULE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLOW UP; GENERAL CONDITION DETERIORATION; HEADACHE; HEARTBURN; HUMAN; MAJOR CLINICAL STUDY; MALE; MUCOCILIARY CLEARANCE; NOSE OBSTRUCTION; NOSE SECRETION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RASH; RHINOSINUSITIS; SIDE EFFECT; SYMPTOMATOLOGY; TREATMENT OUTCOME; TRIGEMINAL NERVE; ACUTE DISEASE; METABOLISM; SINUSITIS;

ACUTE DISEASE; ADULT; ANTI-INFECTIVE AGENTS, LOCAL; C-REACTIVE PROTEIN; CYCLOHEXANOLS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MONOTERPENES; PROSPECTIVE STUDIES; SINUSITIS;

EID: 1842505639     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-200404000-00027     Document Type: Article

References (23)

1. Dorow P. What influence does cineole have on mucociliary clearance? Therapiewoche 1989;39:2652.
2. Kaspar P, Petro W, Swoboda M. Influence of etheric oils on the activity of human cilia. Pneumologie 1990;44:1062.
3. Kaspar P, Repges R, Dethlefsen U, Petro W. Comparison of secretolytics: change of ciliary frequency and lung function after therapy with cineole and Ambroxol. Atemwegs Lungenkrankheiten 1994;20:605-614.
4. Kreutle O. Treatment of acute and chronic sinusitis with Gelomyrtol forte. Therapiewoche 1980;30:2109-2111.
5. Laszig R, Hesse G, Lütgebrune T. Treatment of acute sinusitis with secretolytics. Z Allerg Med 1989;65:19-21.
6. Perleth M, Jakubowski E, Busse R. Assessment of procedures for diagnostic of acute sinusitis maxillaris in adults [abstract]. In: Epidemiologie, Sozialmedizin und Gesundheitsforschung. Hannover: Med Hochschule Hannover, 1999.
7. Wei LJ, Lachin JM. Two-sample asymptotically distribution-free tests for incomplete multivariate observations. J Am Stat Assoc 1984;79:653-661.
8. Lee KJ, ed. Essential Otolaryngology Head and Neck Surgery, 6th ed. Norwalk, CT: Appleton & Lange, 1995.
9. Becker W, Naumann HH, Pfaltz CR. Ear, Nose, and Throat Disease: A Pocket Reference. 2nd ed, rev. New York: Thieme Medical, 1994.
10. Cummings CW, Fredrickson JM, Harker LA, et al., eds. Otolaryngology Head and Neck Surgery, 3rd ed, vol 2. St. Louis, MO: Mosby-Year Book, 1998.
11. Desforges JF. Sinusitis in children. N Engl J Med 1992;323:319-323.
12. Evans KL. Diagnosis and management of sinusitis. BMJ 1994;309:1415-1422.
13. Yonkers A. Sinusitis: inspecting the causes and treatment. Ear Nose Throat J 1991;71:258-262.
14. Clifford K, Huck W, Shan M. Double-blind comparative trial of ciprofloxacin versus clarithromycin in the treatment of acute bacterial sinusitis. Ann Otol Rhinol Laryngol 1999;108:360-367.
15. Edelstein DR, Avner SE, Chow JM, et al. Once-a-day therapy for sinusitis: a comparison study of cefixime and amoxicillin. Laryngoscope 1993;103:33-41.
16. Min YG, Lee CH, Rhee CS, et al. Ciliary beat frequency in cultured human nasal epithelial cells. Ann Otol Rhinol Laryngol 2001;110:1011-1016.
17. van Buchem FL, Knotternus VJJ, Schrijnemaekers M, Peeters F. Primary-care-based randomised placebo-controlled trial of antibiotic treatment in acute maxillary sinusitis. Lancet 1997;349:683-687.
18. Beuscher N, Kietzmann M, Bien E, Champeroux P. Interference of Myrtol standardized with inflammatory and allergic mediators. Arzneim Forsch Drug Res 1998;10:985-989.
19. Federspil P, Wulokow R, Zimmermann T. Efficacy of Myrtol standardized in the therapy of acute sinusitis: results of a double blind, randomised, placebo-controlled multicentre trial. Laryngorhinootologie 1997;76:23-27.
20. Juergens UR, Stöber M, Vetter H. Steroid-like inhibition of monocyte arachidonic acid metabolism and IL-1β production by Eucalyptole (1.8-cineole). Atemwegs Lungenerkrankungen 1998;24:3-11.
21. Behrbohm H, Kaschke O, Sydow K. Influence of the secretolytic drug Gelomyrtol forte on mucociliary clearance of the maxillary sinus. Laryngorhinootologie 1995;74:733-737.
22. Meister R, Wittig T, Beuscher N, de Mey C. Efficacy and tolerability of Myrtol standardized in long-term treatment of chronic bronchitis. Arzneim Forsch Drug Res 1999;4:351-358.
23. Wittmann M, Petro W, Kaspar P, Repges R, Dethlefsen U. Therapy with expectorants in COPD patients: a double-blind randomised study comparing Ambroxol and cineole. Atemwegs Lungenkrankheiten 1998;12:67-74.