Predictors of left ventricular thrombus formation in patients with dilated cardiomyopathy: Role of activated protein C resistance

Coronary Artery Disease

Volumn 15, Issue 2, 2004, Pages 107-110

  Erbay, Ali Riza ^a   Turhan, Hasan ^a   Senen, Kubilay ^a   Yetkin, Funda ^b   Ayaz, Selime ^c   Kara, Fusun ^a   Buyukasik, Naciye S ^d   Yetkin, Ertan ^b  

^a GAZI UNIVERSITY FACULTY OF MEDICINE   (Turkey)

^b INONU UNIVERSITY   (Turkey)

^c GAZI UNIVERSITY   (Turkey)

^d ANKARA NUMUNE HOSPITAL   (Turkey)

Author keywords

Activated protein c resistance; Dilated cardiomyopathy; Left ventricular thrombus

Indexed keywords

ACTIVATED PROTEIN C; ANTITHROMBIN; FIBRINOGEN; PROTEIN S;

ADULT; ARTICLE; CARDIOMYOPATHY; CONGESTIVE CARDIOMYOPATHY; ECHOCARDIOGRAPHY; FEMALE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART VENTRICLE THROMBOSIS; HEMATOLOGICAL PARAMETERS; HUMAN; INTRACARDIAC THROMBOSIS; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; THROMBOSIS;

ACTIVATED PROTEIN C RESISTANCE; ANTITHROMBIN III; CARDIOMYOPATHY, DILATED; CHI-SQUARE DISTRIBUTION; CORONARY THROMBOSIS; FEMALE; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROTEIN S; REGRESSION ANALYSIS; RISK FACTORS;

EID: 1842505385     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019501-200403000-00006     Document Type: Article

References (18)

1. Fuster V, Gersh BJ, Giuliani ER, Tajik AJ, Brandenburg RO, Frye RL. The natural history of idiopathic dilated cardiomyopathy. Am J Cardiol 1981; 47:525-530.
2. Wilensky RL, Jung SC. Thromboembolism in patients with decreased left ventricular function: incidence, risk, and treatment. J Cardiovasc Risk 1995; 2:91-96.
3. Roberts WC, Siegel RJ, McManus BM. Idiopathic dilated cardiomyopathy: analysis of 152 necropsy patients. Am J Cardiol 1987; 60:1340-1355.
4. Yokota Y, Kawanishi H, Hayakawa M, Kumaki T, Takarada A, Nakanishi O, et al. Cardiac thrombus in dilated cardiomyopathy. Relationship between left ventricular pathophysiology and left ventricular thrombus. Jpn Heart J 1989; 30:1-11.
5. Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to actuated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90:1004-1008.
6. Dahlback B. Factor V gene mutation causing inherited resistance to activated protein C as a basis for venous thromboembolism. J Intern Med 1995; 237:221-227.
7. Griffin JH, Evatt B, Wideman C, Fernandez JA. Anticoagulant protein C pathway defective in majority of thrombophilic patients. Blood 1993; 82:1989-1993.
8. Koster T, Rosendaal FR, de Ronde H, Briet E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C resistance: Ledien Thrombophilia study. Lancet 1993; 342:517-522.
9. Sharma ND, McCullough PA, Philbin EF, Weaver WD. Left ventricular thrombus and subsequent thromboembolism in patients with severe systolic dysfunction. Chest 2000; 117:314-320.
10. Asinger RW, Mikell FL, Elsperger J, Hodges M. Incidence of left ventricular thrombosis after acute transmural myocardial infarction: serial evaluation by two-dimensional echocardiography. New Engl J Med 1981; 305:297-302.
11. Bertina RM, Koeleman B, Kosler T, Rosendaal FR, Dirven RJ, de Ronde H, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994, 369:64-67
12. Dahlback B. Inherited thrombophilia: resistance to activated protein C as a pathogenetic risk factor for venous thromboembolism. Blood 1995; 85:607-614.
13. Swenson P, Dahlback B. Resistance to activated protein C as a basis for venous thrombosis. New Engl J Med 1994; 330:517-522.
14. Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V leiden. Blood 1995; 85:1504-1508.
15. Yetkin E, Erbay AR, Ayaz S, Ileri M, Yanik A, Yetkin G, et al. Predictors of left ventricular thrombus formation in patients with anterior myocardial infarction: Role of activated protein C resistance. Coron Artery Dis 2000; 11:269-272.
16. Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nishioka K, et al. Left ventricular apical thrombus formation in a patient with suspected takotsubo-like left ventricular dysfunction. Circ J 2003; 67:556-558.
17. Hisar I, Ileri M, Yetkin E, Atak R, Senen K, Kosar F, et al. Role of activated protein C resistance in left atrial thrombogenesis in patients with mitral stenosis. Angiology 2000; 51:855-860.
18. Bloemenkamp KW, Rosendaal FR, Helmerhorst FM, Buller HR, Vandenbroucke JP. Enhancement by factor Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third-generation progestogen. Lancet 1995; 346:1593-1596.