Tuberoinfundibular peptide of 39 residues produces anxiolytic and antidepressant actions

NeuroReport

Volumn 15, Issue 5, 2004, Pages 881-885

  LaBuda, Christopher J ^a,b   Dobolyi, Arpad ^a,c   Usdin, Ted B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b ADOLOR CORPORATION   (United States)

^c EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Anxiety; Behavior; Depression; Immediate early gene; Neuropeptide; Parathyroid hormone 2 receptor

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CELL PROTEIN; PARATHYROID HORMONE RECEPTOR 2; PARATHYROID HORMONE RELATED PROTEIN; PEPTIDE; PROTEIN TIP39; TUBEROINFUNDIBULAR PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ANXIETY; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DEPRESSION; FORCED SWIMMING TEST; LIMBIC SYSTEM; MAZE TEST; NONHUMAN; OPEN FIELD BEHAVIOR; PEPTIDE ANALYSIS; PONS; PREOPTIC AREA; PRIORITY JOURNAL; RECEPTOR DENSITY; THALAMUS; TRANQUILIZING ACTIVITY;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; BRAIN; CHOICE BEHAVIOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; EXPLORATORY BEHAVIOR; IMMOBILIZATION; IMMUNOHISTOCHEMISTRY; MALE; NEUROPEPTIDES; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SWIMMING; TIME FACTORS;

EID: 1842504414     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200404090-00030     Document Type: Article

References (25)

1. Usdin TB, Hoare SRJ, Wang T, Mezey É and Kowalak JA. TIP39: a new neuropeptide and PTH2-recepor agonist from hypothalamus. Nature Neurosci 2, 941-943 (1999).
2. Dobolyi A, Palkovits M and Usdin TB. Expression and distribution of tuberoinfundibular peptide of 39 residues in the rat central nervous system. J Comp Neurol 455, 547-566 (2003).
3. Wang T, Palkovits M, Rusnak M, Mezey E and Usdin TB. Distribution of parathyroid hormone-2 receptor-like immunoreactivity and messenger RNA in the rat nervous system. Neuroscience 100, 629-649 (2000).
4. Dobolyi A, Ueda H, Uchida H, Palkovits M and Usdin TB. Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. Proc Natl Acad Sci USA 99, 1651-1656 (2002).
5. Ward HL, Small CJ, Murphy KG, Kennedy AR, Ghatei MA and Bloom SR. The actions of tuberoinfundibular peptide on the hypothalamopituitary axes. Endocrinology 142, 3451-3456 (2001).
6. Drevets WC. Neuroimaging studies of mood disorders. Biol Psychiatry 48, 813-829 (2000).
7. Kent JM and Rauch SL. Neurocircuitry of anxiety disorders. Curr Psychiatry Rep 5, 266-273 (2003).
8. Manji HK, Drevets WC and Charney DS. The cellular neurobiology of depression. Nature Med 7, 541-547 (2001).
9. Menard J and Treit D. Effects of centrally administered anxiolytic compounds in animal models of anxiety. Neurosci Biobehav Rev 23, 591-613 (1999).
10. Pellow S, Chopin P, File SE and Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14, 149-167 (1985).
11. Cryan JF, Markou A and Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 23, 238-245 (2002).
12. Hoare SR, Clark JA and Usdin TB. Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity. J Biol Chem 275, 27274-27283 (2000).
13. Singewald N, Salchner P and Sharp T. Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. Biol Psychiatry 53, 275-283 (2003).
14. Duncan GE, Knapp DJ and Breese GR. Neuroanatomical characterization of Fos induction in rat behavioral models of anxiety. Brain Res 713, 79-91 (1996).
15. Campeau S, Falls WA, Cullinan WE and Helmreich DL, Davis M, Watson SJ. Elicitation and reduction of fear: behavioural and neuroendocrine indices and brain induction of the immediate-early gene c-fos. Neuroscience 78, 1087-1104 (1997).
16. Pezzone MA, Lee WS, Hoffman GE and Rabin BS. Induction of c-Fos immunoreactivity in the rat forebrain by conditioned and unconditioned aversive stimuli. Brain Res 597, 41-50 (1992).
17. Sullivan RM and Gratton A. Lateralized effects of medial prefrontal cortex lesions on neuroendocrine and autonomie stress responses in rats. J Neurosci 19, 2834-2840 (1999).
18. Feldman S and Conforti N. Modifications of adrenocortical responses following frontal cortex simulation in rats with hypothalamic deafferentations and medial forebrain bundle lesions. Neuroscience. 15, 1045-1047 (1985).
19. Dobrakovova M, Kvetnansky R, Torda T and Murgas K. Changes of plasma and adrenal catecholamines and corticosterone in stressed rats with septal lesions. Physiol Behav 29, 41-45 (1982).
20. Seggie J. Differential responsivity of corticosterone and prolactin to stress following lesions of the septum or amygdala: implications for psychoneuroendocrinology. Prog Neuropsychopharmacol Biol Psychiatry 11, 315-324 (1987).
21. Viau V and Meaney MJ. The inhibitory effect of testosterone on hypothalamic-pituitary-adrenal responses to stress is mediated by the medial preoptic area. J Neurosci 16, 1866-1876 (1996).
22. Feldman S, Conforti N and Saphier D. The preoptic area and bed nucleus of the stria terminalis are involved in the effects of the amygdala on adrenocortical secretion. Neuroscience 37, 775-779 (1990).
23. Stogner KA and Holmes PV. Neuropeptide-Y exerts antidepressant-like effects in the forced swim test in rats. Eur J Pharmacol 387, R9-R10 (2000).
24. Borowsky B, Durkin MM, Ogozalek K, Marzabadi MR, DeLeon J, Lagu B et al. Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nature Med 8, 825-830 (2002).
25. Rupniak NM. New insights into the antidepressant actions of substance P (NK1 receptor) antagonists. Can J Physiol Pharmacol 80, 489-494 (2002).