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Volumn 1012, Issue , 2004, Pages 94-114

Nutritional iron deprivation attenuates kainate-induced neurotoxicity in rats: Implications for involvement of iron in neurodegeneration

Author keywords

Epilepsy; Hippocampus; Iron; Kainate; Microglia; Neurodegeneration; Oxidative stress; Piriform cortex; Thalamus; Zinc

Indexed keywords

IRON; KAINIC ACID; ZINC;

EID: 1842504330     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1306.008     Document Type: Article
Times cited : (19)

References (80)
  • 1
    • 0029896297 scopus 로고    scopus 로고
    • Neuronal synchrony in relation to burst discharge in epileptic human temporal lobes
    • COLOER, B.W. et al. 1996. Neuronal synchrony in relation to burst discharge in epileptic human temporal lobes. J. Neurophysiol. 75: 2496-2508.
    • (1996) J. Neurophysiol. , vol.75 , pp. 2496-2508
    • Coloer, B.W.1
  • 2
    • 0021921141 scopus 로고
    • Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy
    • BEN-ARI, Y. 1985. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14: 375-403.
    • (1985) Neuroscience , vol.14 , pp. 375-403
    • Ben-Ari, Y.1
  • 3
    • 0019501929 scopus 로고
    • Kainic acid induced limbic seizures: Metabolic, behavioral, electroencephalographic, and neuropathological correlates
    • LOTHMAN, E.W. & R.C. COLLINS. 1981. Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic, and neuropathological correlates. Brain Res. 218: 299-318.
    • (1981) Brain Res. , vol.218 , pp. 299-318
    • Lothman, E.W.1    Collins, R.C.2
  • 4
    • 0026705552 scopus 로고
    • Modulation of pH by neuronal activity
    • CHESLER, M. & K. KAILA. 1992. Modulation of pH by neuronal activity. TINS 15: 396-402.
    • (1992) TINS , vol.15 , pp. 396-402
    • Chesler, M.1    Kaila, K.2
  • 5
    • 0021689422 scopus 로고
    • The role of brain edema in epileptic brain damage induced by systemic kainic acid injection
    • LASSMAN, H. et al. 1984. The role of brain edema in epileptic brain damage induced by systemic kainic acid injection. Neuroscience 13: 691-704.
    • (1984) Neuroscience , vol.13 , pp. 691-704
    • Lassman, H.1
  • 6
    • 0030044858 scopus 로고    scopus 로고
    • Apoptotic features of selective neuronal death in ischemia, epilepsy, and gp120 toxicity
    • CHARRIAUT-MARLANGUE, D., A. AGOUN-ZOUAOUI, Y. REPRESA & Y. BEN-ARI. 1996. Apoptotic features of selective neuronal death in ischemia, epilepsy, and gp120 toxicity. TINS 19: 109-114.
    • (1996) TINS , vol.19 , pp. 109-114
    • Charriaut-Marlangue, D.1    Agoun-Zouaoui, A.2    Represa, Y.3    Ben-Ari, Y.4
  • 7
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • COYLE, J.T. & P. PUTTFARCKEN. 1993. Oxidative stress, glutamate, and neurodegenerative disorders. Science 262: 689-695.
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 8
    • 0030872357 scopus 로고    scopus 로고
    • Kainate-induced hippocampal DNA damage is attenuated in superoxide dismutase transgenic mice
    • HIRATA, H. & J.L. CADET. 1997. Kainate-induced hippocampal DNA damage is attenuated in superoxide dismutase transgenic mice. Mol. Brain Res. 48: 145-148.
    • (1997) Mol. Brain Res. , vol.48 , pp. 145-148
    • Hirata, H.1    Cadet, J.L.2
  • 9
    • 0030934087 scopus 로고    scopus 로고
    • DNA fragmentation and prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase
    • KONDO, T. et al. 1997. DNA fragmentation and prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase. J. Cereb. Blood Flow Metab. 17: 241-256.
    • (1997) J. Cereb. Blood Flow Metab. , vol.17 , pp. 241-256
    • Kondo, T.1
  • 10
    • 0033011225 scopus 로고    scopus 로고
    • The antioxidant melatonin reduces cortical neuronal death after intrastriatal injection of kainate in the rat
    • CHEN, S.T. & J.I. CHUANG. 1999. The antioxidant melatonin reduces cortical neuronal death after intrastriatal injection of kainate in the rat. Exp. Brain Res. 124: 241-247.
    • (1999) Exp. Brain Res. , vol.124 , pp. 241-247
    • Chen, S.T.1    Chuang, J.I.2
  • 11
    • 0035937495 scopus 로고    scopus 로고
    • Protective effect of the antioxidant 6-ethoxy-2,2-pentamethylen-1,2- dihydroquinoline (S 33113) in models of cerebral neurodegeneration
    • LOCKHART, B. et al. 2001. Protective effect of the antioxidant 6-ethoxy-2,2-pentamethylen-1,2-dihydroquinoline (S 33113) in models of cerebral neurodegeneration. Eur. J. Pharmacol. 416: 59-68.
    • (2001) Eur. J. Pharmacol. , vol.416 , pp. 59-68
    • Lockhart, B.1
  • 12
    • 0034683193 scopus 로고    scopus 로고
    • Phenidone prevents kainate-induced neurotoxicity via antioxidant mechanisms
    • KIM, H.C. et al. 2000. Phenidone prevents kainate-induced neurotoxicity via antioxidant mechanisms. Brain Res. 874: 15-23.
    • (2000) Brain Res. , vol.874 , pp. 15-23
    • Kim, H.C.1
  • 13
    • 0034678528 scopus 로고    scopus 로고
    • Intracellular glutathione levels determine cerebellar granule neuron sensitivity to excitotoxic injury by kainic acid
    • CECCON, M. et al. 2000. Intracellular glutathione levels determine cerebellar granule neuron sensitivity to excitotoxic injury by kainic acid. Brain Res. 862: 83-89.
    • (2000) Brain Res. , vol.862 , pp. 83-89
    • Ceccon, M.1
  • 14
    • 0033402469 scopus 로고    scopus 로고
    • Excitotoxicity, oxidative stress, and the neuroprotective potential of melatonin
    • SKAPER, S.D. et al. 1999. Excitotoxicity, oxidative stress, and the neuroprotective potential of melatonin. Ann. N.Y. Acad. Sci. 890: 107-118.
    • (1999) Ann. N.Y. Acad. Sci. , vol.890 , pp. 107-118
    • Skaper, S.D.1
  • 15
    • 0021351203 scopus 로고
    • Oxygen toxicity, oxygen radicals, transition metals, and disease
    • HALLIWELL, B.J. & J.M.C. GUTTERIDGE. 1984. Oxygen toxicity, oxygen radicals, transition metals, and disease. Biochem. J. 219: 1-14.
    • (1984) Biochem. J. , vol.219 , pp. 1-14
    • Halliwell, B.J.1    Gutteridge, J.M.C.2
  • 17
    • 1642555537 scopus 로고    scopus 로고
    • Iron involvement in neural damage and microgliosis in models of neurodegenerative diseases
    • Noisy-Le-Grand
    • SHOHAM, S. & M.B.H. YOUDIM. 2000. Iron involvement in neural damage and microgliosis in models of neurodegenerative diseases. Cell. Mol. Biol. (Noisy-Le-Grand) 46: 743-760.
    • (2000) Cell. Mol. Biol. , vol.46 , pp. 743-760
    • Shoham, S.1    Youdim, M.B.H.2
  • 18
    • 0025622915 scopus 로고
    • The role of monoamine oxidase, iron-melatonin interaction, and intracellular calcium in Parkinson's disease
    • YOUDIM, M.B.H., D. BEN-SHACHAR & P. RIEOERER. 1990. The role of monoamine oxidase, iron-melatonin interaction, and intracellular calcium in Parkinson's disease. J. Neural Transm. Suppl. 32: 239-248.
    • (1990) J. Neural Transm. Suppl. , vol.32 , pp. 239-248
    • Youdim, M.B.H.1    Ben-Shachar, D.2    Rieoerer, P.3
  • 19
    • 0027329926 scopus 로고
    • The role of iron in senescence of dopaminergic neurons in Parkinson's disease
    • YOUDIM, M.B.H. & P. RIEDERER. 1993. The role of iron in senescence of dopaminergic neurons in Parkinson's disease. J. Neural Transm. Suppl. 40: 57-67.
    • (1993) J. Neural Transm. Suppl. , vol.40 , pp. 57-67
    • Youdim, M.B.H.1    Riederer, P.2
  • 20
    • 3042530369 scopus 로고    scopus 로고
    • Iron in normal and pathological brain
    • Elsevier. Amsterdam. In press
    • YOUDIM, M.B.H. & P. RIEDERER. 2003. Iron in normal and pathological brain. In Encyclopedia of Neuroscience. Elsevier. Amsterdam. In press.
    • (2003) Encyclopedia of Neuroscience
    • Youdim, M.B.H.1    Riederer, P.2
  • 21
    • 0025980955 scopus 로고
    • The iron chelator desferrioxamine (desferal) retards 6-hydroxydopamine- induced degeneration of nigrostriatal neurons
    • BEN-SHACHAR, D., G. ESHEL, J.P.M. FINBERG & M.B.H. YOUDIM. 1991. The iron chelator desferrioxamine (desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal neurons. J. Neurochem. 56: 1441-1444.
    • (1991) J. Neurochem. , vol.56 , pp. 1441-1444
    • Ben-Shachar, D.1    Eshel, G.2    Finberg, J.P.M.3    Youdim, M.B.H.4
  • 22
    • 0242684415 scopus 로고    scopus 로고
    • Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinson's disease
    • KAUR, D. et al. 2003. Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. Neuron 37: 899-909.
    • (2003) Neuron , vol.37 , pp. 899-909
    • Kaur, D.1
  • 23
    • 1842621271 scopus 로고    scopus 로고
    • Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lesion in rats
    • In press
    • BEN-SHACHAR, D. et al. 2003. Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lesion in rats. Neuropharmacology. In press.
    • (2003) Neuropharmacology
    • Ben-Shachar, D.1
  • 24
    • 0030666415 scopus 로고    scopus 로고
    • Excessive iron accumulation in the brain: A possible potential risk of neurodegeneration in Parkinson's disease
    • LAN, J. & D.H. JIANG. 1997. Excessive iron accumulation in the brain: a possible potential risk of neurodegeneration in Parkinson's disease. J. Neural Transm. 104: 649-660.
    • (1997) J. Neural Transm. , vol.104 , pp. 649-660
    • Lan, J.1    Jiang, D.H.2
  • 25
    • 1842516707 scopus 로고    scopus 로고
    • Effect of dietary iron on motor behaviour and neuronal death in an experimental model of parkinsonism
    • In press
    • LEVENSON, C.W. et al. 2003. Effect of dietary iron on motor behaviour and neuronal death in an experimental model of parkinsonism. J. Am. Aging Assoc. In press.
    • (2003) J. Am. Aging Assoc.
    • Levenson, C.W.1
  • 26
    • 0021329973 scopus 로고
    • The regional distribution and cellular localization of iron in the rat brain
    • HILL, J.M. & C. SWITZER III. 1984. The regional distribution and cellular localization of iron in the rat brain. Neuroscience 11: 596-603.
    • (1984) Neuroscience , vol.11 , pp. 596-603
    • Hill, J.M.1    Switzer III, C.2
  • 27
    • 0036197931 scopus 로고    scopus 로고
    • Increase in ferric and ferrous iron in the rat hippocampus with time after kainate-induced excitotoxic injury
    • WANG, X.S., W.Y. ONG & J.R. CONNOR. 2002. Increase in ferric and ferrous iron in the rat hippocampus with time after kainate-induced excitotoxic injury. Exp. Brain Res. 143: 137-148.
    • (2002) Exp. Brain Res. , vol.143 , pp. 137-148
    • Wang, X.S.1    Ong, W.Y.2    Connor, J.R.3
  • 28
    • 0036434205 scopus 로고    scopus 로고
    • A light and electron microscopic study of divalent metal transporter-1 distribution in the rat hippocampus, after kainate-induced neuronal injury
    • WANG, X.S., W.Y. ONG & J.R. CONNOR. 2002. A light and electron microscopic study of divalent metal transporter-1 distribution in the rat hippocampus, after kainate-induced neuronal injury. Exp. Neurol. 177: 193-201.
    • (2002) Exp. Neurol. , vol.177 , pp. 193-201
    • Wang, X.S.1    Ong, W.Y.2    Connor, J.R.3
  • 29
    • 0037491244 scopus 로고    scopus 로고
    • Quinacrine attenuates increases in divalent metal transporter-1 and iron levels in the rat hippocampus, after kainate-induced neuronal injury
    • WANG, X.S., W.Y. ONG & J.R. CONNOR. 2003. Quinacrine attenuates increases in divalent metal transporter-1 and iron levels in the rat hippocampus, after kainate-induced neuronal injury. Neuroscience 120: 21-29.
    • (2003) Neuroscience , vol.120 , pp. 21-29
    • Wang, X.S.1    Ong, W.Y.2    Connor, J.R.3
  • 30
    • 0026475580 scopus 로고
    • Iron accumulation in the rat basal ganglia after excitatory amino acid injections - Dissociation from neuronal loss
    • SHOHAM, S., E. WERTMAN & P. EBSTEIN. 1992. Iron accumulation in the rat basal ganglia after excitatory amino acid injections - dissociation from neuronal loss. Exp. Neurol. 118: 227-241.
    • (1992) Exp. Neurol. , vol.118 , pp. 227-241
    • Shoham, S.1    Wertman, E.2    Ebstein, P.3
  • 31
    • 0032994492 scopus 로고    scopus 로고
    • A nuclear microscopic study of elemental changes in the rat hippocampus after kainite-induced neuronal injury
    • ONG, W.Y. et al. 1999. A nuclear microscopic study of elemental changes in the rat hippocampus after kainite-induced neuronal injury. J. Neurochem. 72: 1574-1579.
    • (1999) J. Neurochem. , vol.72 , pp. 1574-1579
    • Ong, W.Y.1
  • 32
    • 0032144474 scopus 로고    scopus 로고
    • Kainic acid induction of heme oxygenase in vivo and in vitro
    • MATSUOKA, Y. et al. 1998. Kainic acid induction of heme oxygenase in vivo and in vitro. Neuroscience 85: 1223-1233.
    • (1998) Neuroscience , vol.85 , pp. 1223-1233
    • Matsuoka, Y.1
  • 33
    • 0016742687 scopus 로고
    • Brain iron: Persistent deficiency following short term iron deprivation in the young rat
    • DALLMAN, P.R., M.N. SIIMES & E.C. MANIES. 1975. Brain iron: persistent deficiency following short term iron deprivation in the young rat. Br. J. Haematol. 31: 209-215.
    • (1975) Br. J. Haematol. , vol.31 , pp. 209-215
    • Dallman, P.R.1    Siimes, M.N.2    Manies, E.C.3
  • 34
    • 0018014346 scopus 로고
    • Iron deficiency and neurotransmitter synthesis and function
    • YOUDIM, M.B. & A.R. GREEN. 1978. Iron deficiency and neurotransmitter synthesis and function. Proc. Nutr. Soc. 37: 173-179.
    • (1978) Proc. Nutr. Soc. , vol.37 , pp. 173-179
    • Youdim, M.B.1    Green, A.R.2
  • 35
    • 0024434025 scopus 로고
    • Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior
    • YOUDIM, M.B.H., D. BEN-SHACHAR & S. YEHUDA. 1989. Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior. Am. J. Clin. Nutr. 50: 607-617.
    • (1989) Am. J. Clin. Nutr. , vol.50 , pp. 607-617
    • Youdim, M.B.H.1    Ben-Shachar, D.2    Yehuda, S.3
  • 36
    • 0018875855 scopus 로고
    • The effects of iron deficiency on brain biogenic monoamine biochemistry and function in rats
    • YOUDIM, M.B. et al. 1980. The effects of iron deficiency on brain biogenic monoamine biochemistry and function in rats. Neuropharmacology 19: 259-267.
    • (1980) Neuropharmacology , vol.19 , pp. 259-267
    • Youdim, M.B.1
  • 37
    • 0002404319 scopus 로고    scopus 로고
    • Brain iron: Function and dysfunction in relation to cognitive processes
    • Libbey. London
    • SHOHAM, S., Y. GLINKA, Z. TANNE & M.B.H. YOUDIM. 1996. Brain iron: function and dysfunction in relation to cognitive processes. In Iron Nutrition in Health and Disease, pp. 205-218. Libbey. London.
    • (1996) Iron Nutrition in Health and Disease , pp. 205-218
    • Shoham, S.1    Glinka, Y.2    Tanne, Z.3    Youdim, M.B.H.4
  • 39
    • 0023833925 scopus 로고
    • Zinc neurotoxicity in cortical cell culture
    • CHOI, D.W., M. YOKOYAMA & J. KOH. 1988. Zinc neurotoxicity in cortical cell culture. Neuroscience 24: 67-79.
    • (1988) Neuroscience , vol.24 , pp. 67-79
    • Choi, D.W.1    Yokoyama, M.2    Koh, J.3
  • 40
    • 0024477326 scopus 로고
    • Translocation of zinc may contribute to seizure-induced death of neurons
    • FREDERICKSON, C.J., M.D. HERNANDEZ & J.F. MCGINTY. 1989. Translocation of zinc may contribute to seizure-induced death of neurons. Brain Res. 480: 317-321.
    • (1989) Brain Res. , vol.480 , pp. 317-321
    • Frederickson, C.J.1    Hernandez, M.D.2    McGinty, J.F.3
  • 41
    • 0032588001 scopus 로고    scopus 로고
    • Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures
    • KIM, E.Y. et al. 1999. Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures. Eur. J. Neurosci. 11: 327-334.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 327-334
    • Kim, E.Y.1
  • 42
    • 84971195191 scopus 로고
    • Studies in iron metabolism. 1. The experimental production of iron deficiency in the growing rat
    • MCCALL, M.G. et al. 1960. Studies in iron metabolism. 1. The experimental production of iron deficiency in the growing rat. Br. J. Nutr. 16: 297-304.
    • (1960) Br. J. Nutr. , vol.16 , pp. 297-304
    • McCall, M.G.1
  • 43
    • 0028234844 scopus 로고
    • Ultrastructural and cytochemical changes in the heart of iron-deficient rats
    • TANNE, Z. et al. 1994. Ultrastructural and cytochemical changes in the heart of iron-deficient rats. Biochem. Pharmacol. 47: 1759-1766.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 1759-1766
    • Tanne, Z.1
  • 44
    • 0022654236 scopus 로고
    • Long-term consequence of early iron-deficiency on dopaminergic neurotransmission in rats
    • BEN-SHACHAR, D., R. ASHKENAZI & M.B. YOUDIM. 1986. Long-term consequence of early iron-deficiency on dopaminergic neurotransmission in rats. Int. J. Dev. Neurosci. 4: 81-88.
    • (1986) Int. J. Dev. Neurosci. , vol.4 , pp. 81-88
    • Ben-Shachar, D.1    Ashkenazi, R.2    Youdim, M.B.3
  • 45
    • 84886639406 scopus 로고
    • Kainic acid-induced seizures: Dose-relationship of behavioural, neurochemical, and histopathological changes
    • SPERK, G. et al. 1985. Kainic acid-induced seizures: dose-relationship of behavioural, neurochemical, and histopathological changes. Brain Res. 338: 289-295.
    • (1985) Brain Res. , vol.338 , pp. 289-295
    • Sperk, G.1
  • 46
    • 0025337139 scopus 로고
    • Golgi-like demonstration of "dark" neurons with an argyrophil III method for experimental neuropathology
    • GALLYAS, F., F.H. GULDNER, G. ZOLTAGY & R. WOLFF. 1990. Golgi-like demonstration of "dark" neurons with an argyrophil III method for experimental neuropathology. Acta Neuropathol. 79: 620-628.
    • (1990) Acta Neuropathol. , vol.79 , pp. 620-628
    • Gallyas, F.1    Guldner, F.H.2    Zoltagy, G.3    Wolff, R.4
  • 47
    • 0031258524 scopus 로고    scopus 로고
    • The distribution of beta amyloid precursor protein in rat cortex after kainate-induced seizures
    • SHOHAM, S. & R.P. EBSTEIN. 1997. The distribution of beta amyloid precursor protein in rat cortex after kainate-induced seizures. Exp. Neurol. 147: 361-376.
    • (1997) Exp. Neurol. , vol.147 , pp. 361-376
    • Shoham, S.1    Ebstein, R.P.2
  • 49
    • 15844427058 scopus 로고    scopus 로고
    • Hemoglobin potentiates excitotoxic injury in cortical cell culture
    • REGAN, R.F. & S.S. PANTER. 1996. Hemoglobin potentiates excitotoxic injury in cortical cell culture. Neurotrauma 13: 223-231.
    • (1996) Neurotrauma , vol.13 , pp. 223-231
    • Regan, R.F.1    Panter, S.S.2
  • 50
    • 0028917654 scopus 로고
    • Oxygen free radicals in rat limbic structures after kainate-induced seizures
    • BRUCE, A.J. & M. BAUDRY. 1995. Oxygen free radicals in rat limbic structures after kainate-induced seizures. Free Radical Biol. Med. 18: 993-1002.
    • (1995) Free Radical Biol. Med. , vol.18 , pp. 993-1002
    • Bruce, A.J.1    Baudry, M.2
  • 51
    • 0034787748 scopus 로고    scopus 로고
    • Selective vulnerability to kainate-induced oxidative damage in different rat brain regions
    • CANDELARIO-JALIL, E. et al. 2001. Selective vulnerability to kainate-induced oxidative damage in different rat brain regions. J. Appl. Toxicol. 21: 403-407.
    • (2001) J. Appl. Toxicol. , vol.21 , pp. 403-407
    • Candelario-Jalil, E.1
  • 52
    • 0033384479 scopus 로고    scopus 로고
    • Reactive oxidant species in piriform cortex extracellular fluid during seizures induced by systemic kainic acid in rats
    • LAYTON, M.E. & T.L. PAZDERNIK. 1999. Reactive oxidant species in piriform cortex extracellular fluid during seizures induced by systemic kainic acid in rats. J. Mol. Neurosci. 13: 63-68.
    • (1999) J. Mol. Neurosci. , vol.13 , pp. 63-68
    • Layton, M.E.1    Pazdernik, T.L.2
  • 55
    • 0027337274 scopus 로고
    • 45Ca uptake and acute toxicity mediated by the N-methyl-D-aspartate receptor: The effect of metal binding agents and transition metal ions
    • 45Ca uptake and acute toxicity mediated by the N-methyl-D-aspartate receptor: the effect of metal binding agents and transition metal ions. J. Neurochem. 61: 518-525.
    • (1993) J. Neurochem. , vol.61 , pp. 518-525
    • Eimerl, S.1    Schramm, M.2
  • 56
    • 17444437198 scopus 로고    scopus 로고
    • Effect of systemic zinc administration on delayed neuronal death in the gerbil hippocampus
    • MATSUSHITA, K. et al. 1996. Effect of systemic zinc administration on delayed neuronal death in the gerbil hippocampus. Brain Res. 743: 362-365.
    • (1996) Brain Res. , vol.743 , pp. 362-365
    • Matsushita, K.1
  • 57
    • 0023735768 scopus 로고
    • Protective effects of mossy fiber lesions against kainic acid-induced seizures and neuronal degeneration
    • OKAZAKI, M.M. & J. V. NADLER. 1988. Protective effects of mossy fiber lesions against kainic acid-induced seizures and neuronal degeneration. Neuroscience 26: 763-781.
    • (1988) Neuroscience , vol.26 , pp. 763-781
    • Okazaki, M.M.1    Nadler, J.V.2
  • 58
    • 0036387570 scopus 로고    scopus 로고
    • The effects of iron deficiency and iron and zinc supplementation on rat hippocampus ferritin
    • SHOHAM, S. & M.B.H. YOUDIM. 2002. The effects of iron deficiency and iron and zinc supplementation on rat hippocampus ferritin. J. Neural Transm. 109: 1241-1256.
    • (2002) J. Neural Transm. , vol.109 , pp. 1241-1256
    • Shoham, S.1    Youdim, M.B.H.2
  • 59
    • 0026555734 scopus 로고
    • Kainic acid seizures in the developing brain: Status epilepticus and spontaneous recurrent seizures
    • STAFSTROM, C.E., J.L. THOMPSON & G.L. HOLMES. 1992. Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures. Dev. Brain Res. 65: 227-236.
    • (1992) Dev. Brain Res. , vol.65 , pp. 227-236
    • Stafstrom, C.E.1    Thompson, J.L.2    Holmes, G.L.3
  • 60
    • 0034672398 scopus 로고    scopus 로고
    • Neuroprotective signaling and the aging brain: Take away my food and let me run
    • MATTSON, M.P. 2000. Neuroprotective signaling and the aging brain: take away my food and let me run. Brain Res. 886: 47-53.
    • (2000) Brain Res. , vol.886 , pp. 47-53
    • Mattson, M.P.1
  • 61
    • 0032078775 scopus 로고    scopus 로고
    • Iron accumulation in aging: Modulation by dietary restriction
    • COOK, C.I. & B.P. YU. 1998. Iron accumulation in aging: modulation by dietary restriction. Mech. Ageing Dev. 102: 1-13.
    • (1998) Mech. Ageing Dev. , vol.102 , pp. 1-13
    • Cook, C.I.1    Yu, B.P.2
  • 62
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • SOHAL, R.S. & R. WEINDRUCH. 1996. Oxidative stress, caloric restriction, and aging. Science 273: 59-63.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 63
    • 0026702955 scopus 로고
    • Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
    • BOJE, K.M. & P.K. ARORA. 1992. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 587: 250-256.
    • (1992) Brain Res. , vol.587 , pp. 250-256
    • Boje, K.M.1    Arora, P.K.2
  • 64
    • 0037704398 scopus 로고    scopus 로고
    • Modification of microglia function protects from lesion-induced neuronal alterations and promotes sprouting in the hippocampus
    • EYUPOGLU, I.Y., I. BECHMANN & R. NITSCH. 2003. Modification of microglia function protects from lesion-induced neuronal alterations and promotes sprouting in the hippocampus. FASEB J. 17: 1110-1111.
    • (2003) FASEB J. , vol.17 , pp. 1110-1111
    • Eyupoglu, I.Y.1    Bechmann, I.2    Nitsch, R.3
  • 65
    • 0030858597 scopus 로고    scopus 로고
    • Role of iron in NF-kB activation and cytokine gene expression by rat hepatic macrophages
    • LIN, M. et al. 1997. Role of iron in NF-kB activation and cytokine gene expression by rat hepatic macrophages. Am. J. Physiol. 272: G1355-G1364.
    • (1997) Am. J. Physiol. , vol.272
    • Lin, M.1
  • 66
    • 0033373789 scopus 로고    scopus 로고
    • The pivotal role of iron in NF-kappa B activation and nigrostriatal dopaminergic neurodegeneration: Prospects for neuroprotection in Parkinson's disease with iron chelators
    • YOUDIM, M.B., E. GRUNBLATT & S. MANDEL. 1999. The pivotal role of iron in NF-kappa B activation and nigrostriatal dopaminergic neurodegeneration: prospects for neuroprotection in Parkinson's disease with iron chelators. Ann. N.Y. Acad. Sci. 890: 7-25.
    • (1999) Ann. N.Y. Acad. Sci. , vol.890 , pp. 7-25
    • Youdim, M.B.1    Grunblatt, E.2    Mandel, S.3
  • 67
    • 0031172065 scopus 로고    scopus 로고
    • NF-kB: A crucial transcription factor for glial and neuronal cell function
    • O'NEILL, L.A.J. & C. KALTSCMIDT. 1997. NF-kB: a crucial transcription factor for glial and neuronal cell function. TINS 20: 252-258.
    • (1997) TINS , vol.20 , pp. 252-258
    • O'Neill, L.A.J.1    Kaltscmidt, C.2
  • 68
    • 0028281546 scopus 로고
    • Time course of purine protection against kainate-induced increase in hippocampal [3H]-PK11195 binding
    • MILLER, W.J., D.G. MACGREGOR & T.W. STONE. 1994. Time course of purine protection against kainate-induced increase in hippocampal [3H]-PK11195 binding. Brain Res. Bull. 34: 133-136.
    • (1994) Brain Res. Bull. , vol.34 , pp. 133-136
    • Miller, W.J.1    MacGregor, D.G.2    Stone, T.W.3
  • 69
    • 0035876916 scopus 로고    scopus 로고
    • Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia
    • TIKKA, T.M. & J.E. KOISTINAHO. 2001. Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J. Immunol. 166: 7527-7533.
    • (2001) J. Immunol. , vol.166 , pp. 7527-7533
    • Tikka, T.M.1    Koistinaho, J.E.2
  • 70
    • 0028356960 scopus 로고
    • Modulation of GABA-mediated synaptic transmission by endogenous zinc in the immature rat hippocampus in vitro
    • XIE, X., R.C. HIDER & T.G. SMART. 1994. Modulation of GABA-mediated synaptic transmission by endogenous zinc in the immature rat hippocampus in vitro. J. Physiol. 478(pt. 1): 75-86.
    • (1994) J. Physiol. , vol.478 , Issue.1 PART , pp. 75-86
    • Xie, X.1    Hider, R.C.2    Smart, T.G.3
  • 71
    • 0032801853 scopus 로고    scopus 로고
    • Monocytic cells secrete factors that evoke excitatory synaptic activity in rat hippocampal cultures
    • HEGG, C.C. & S.A. THAYER. 1999. Monocytic cells secrete factors that evoke excitatory synaptic activity in rat hippocampal cultures. Eur. J. Pharmacol. 385: 231-237.
    • (1999) Eur. J. Pharmacol. , vol.385 , pp. 231-237
    • Hegg, C.C.1    Thayer, S.A.2
  • 72
    • 0023944385 scopus 로고
    • Xanthine oxidase-derived hydrogen peroxide and iron contribute to ischemia-reperfusion-induced edema in gerbil brain
    • PATT, A. et al. 1988. Xanthine oxidase-derived hydrogen peroxide and iron contribute to ischemia-reperfusion-induced edema in gerbil brain. J. Clin. Invest. 81: 1556-1564.
    • (1988) J. Clin. Invest. , vol.81 , pp. 1556-1564
    • Patt, A.1
  • 73
    • 0025057335 scopus 로고
    • Iron depletion or chelation reduces ischemia-reperfusion-induced edema in gerbil brains
    • PATT, A. et al. 1990. Iron depletion or chelation reduces ischemia-reperfusion-induced edema in gerbil brains. J. Pediatr. Surg. 25: 224-236.
    • (1990) J. Pediatr. Surg. , vol.25 , pp. 224-236
    • Patt, A.1
  • 74
    • 0000612305 scopus 로고
    • Proteins of iron regulation in the brain in Alzheimer's disease
    • CRC Press. Boca Raton, FL
    • CONNOR, J.R. 1992. Proteins of iron regulation in the brain in Alzheimer's disease. In Iron and Human Disease, pp. 366-395. CRC Press. Boca Raton, FL.
    • (1992) Iron and Human Disease , pp. 366-395
    • Connor, J.R.1
  • 75
    • 0025606922 scopus 로고
    • Brain iron and ferritin in Parkinson's and Alzheimer's diseases
    • JELLINGER, K. et al. 1990. Brain iron and ferritin in Parkinson's and Alzheimer's diseases. J. Neural Transm. Parkinson's Dis. Dementia Sect. 2: 327-340.
    • (1990) J. Neural Transm. Parkinson's Dis. Dementia Sect. , vol.2 , pp. 327-340
    • Jellinger, K.1
  • 77
    • 0026558337 scopus 로고
    • Electrophysiology of dentate granule cells after kainate-induced synaptic reorganization of the mossy fibres
    • CRONIN, J., A. OBENHAUS, C.R. HOUSER & F.E. DUDEK. 1992. Electrophysiology of dentate granule cells after kainate-induced synaptic reorganization of the mossy fibres. Brain Res. 573: 305-310.
    • (1992) Brain Res. , vol.573 , pp. 305-310
    • Cronin, J.1    Obenhaus, A.2    Houser, C.R.3    Dudek, F.E.4
  • 78
    • 0026594823 scopus 로고
    • Possible functional consequences of synaptic reorganization in the dentate gyms of kainate-treated rats
    • SLOVITER, R.S. 1992. Possible functional consequences of synaptic reorganization in the dentate gyms of kainate-treated rats. Neurosci. Lett. 137: 91-96.
    • (1992) Neurosci. Lett. , vol.137 , pp. 91-96
    • Sloviter, R.S.1
  • 79
    • 0025832553 scopus 로고
    • Synaptic reorganization by mossy fibres in human epileptic fascia dentata
    • BABB, T.L. et al. 1991. Synaptic reorganization by mossy fibres in human epileptic fascia dentata. Neuroscience 42: 351-363.
    • (1991) Neuroscience , vol.42 , pp. 351-363
    • Babb, T.L.1
  • 80
    • 0031047193 scopus 로고    scopus 로고
    • Treatment of temporal lobe epilepsy
    • OJEMANN, G.A. 1997. Treatment of temporal lobe epilepsy. Annu. Rev. Med. 48: 317-328.
    • (1997) Annu. Rev. Med. , vol.48 , pp. 317-328
    • Ojemann, G.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.