A Randomized Controlled Trial of Silver Sulfadiazine, Biafine, and Saline-soaked Gauze in the Treatment of Superficial Partial-thickness Burn Wounds in Pigs

Academic Emergency Medicine

Volumn 11, Issue 4, 2004, Pages 339-342

  Glesinger, Ronen ^a,c   Cohen, Arnon D ^b,c   Bogdanov Berezovsky, Alex ^a,c   Krieger, Yuval ^a,c   Rosenberg, Lior ^a,c  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b CLALIT HEALTH SERVICES   (Israel)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Biafine; Burns; Partial thickness burns; Re epithelialization; Silver sulfadiazine

Indexed keywords

ALGINIC ACID; BIAFINE; SULFADIAZINE SILVER; WATER OIL CREAM;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BURN; CONTROLLED STUDY; DISEASE SEVERITY; MULTIVARIATE ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RANDOMIZATION; SKINFOLD THICKNESS; STATISTICAL SIGNIFICANCE; SWINE; THICKNESS; WOUND DRESSING;

EID: 1842487561     PISSN: 10696563     EISSN: None     Source Type: Journal    
DOI: 10.1197/j.aem.2003.11.015     Document Type: Article

References (14)

1. Papini RP, Wilson AP, Steer JA, McGrouther DA, Parkhouse N. Wound management in burn centres in the United Kingdom. Br J Surg. 1995; 82:505-9.
2. Singer AJ, Berrutti L, Thode HC Jr, McClain SA. Octylcyanoacrylate for the treatment of partial-thickness burns in pigs: a randomized, controlled experiment. Acad Emerg Med. 1999; 6:688-92.
3. Stern HS. Silver sulphadiazine and the healing of partial thickness burns: a prospective clinical trial. Br J Plast Surg. 1989; 42:581-5.
4. Cruse CW, Daniels S. Minor burns: treatment using a new drug delivery system with silver sulfadiazine. South Med J. 1989; 82:1135-7.
5. Deitch EA, Sittig K, Heimbach D, et al. Results of a multicenter outpatient burn study on the safety and efficacy of Dimac-SSD, a new delivery system for silver sulfadiazine. J Trauma. 1989; 29:430-4.
6. Wassermann D, Schlotterer M, Lebreton F, Levy J, Guelfi MC. Use of topically applied silver sulphadiazine plus cerium nitrate in major burns. Burns. 1989; 15:257-60.
7. Subrahmanyam M. A prospective randomised clinical and histological study of superficial partial-thickness burns healing with honey and silver sulfadiazine. Burns. 1998; 24:157-61.
8. Marone P, Monzillo V, Perversi L, Carretto E. Comparative in vitro activity of silver sulfadiazine, alone and in combination with cerium nitrate, against staphylococci and gram-negative bacteria. J Chemother. 1998; 10:17-21.
9. Coulomb B, Friteau L, Dubertret L. Biafine applied on human epidermal wounds is chemotactic for macrophages and increases the IL-1/IL-6 ratio. Skin Pharmacol. 1997; 10:281-7.
10. Le Coz CJ, Scrivener Y, Santinelli F, Heid E. [Contact sensitization in leg ulcers.] Sensibilisation de contact au cours des ulceres de jambe. Ann Dermatol Venereol. 1998; 125:694-9.
11. Sullivan TP, Eaglstein WH, Davis SC, Mertz P. The pig as a model for human wound healing. Wound Repair Regen. 2001; 9:66-76.
12. Singer AJ, Thode HC Jr, McClain SA. The effects of epidermal debridement of partial-thickness burns on infection and reepithelialization in swine. Acad Emerg Med. 2000; 7:114-9.
13. Winter GD. Effect of air exposure and occlusion on experimental human skin wounds. Nature. 1963; 194:377.
14. Winter GD. Formation of the scab and the rate of epithelialization of superficial wounds in the skin of the young domestic pig. Nature. 1962; 193:293-4.