Perillyl alcohol inhibits human breast cancer cell growth in vitro and in vivo

Breast Cancer Research and Treatment

Volumn 84, Issue 3, 2004, Pages 251-260

  Yuri, Takashi ^a   Danbara, Naoyuki ^a   Tsujita Kyutoku, Miki ^a   Kiyozuka, Yasuhiko ^a   Senzaki, Hideto ^a   Shikata, Nobuaki ^a   Kanzaki, Hideharu ^a   Tsubura, Airo ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Breast cancer; Cyclin D1; Cyclin E; Monoterpene; p21Cip1 Waf1; Perillyl alcohol

Indexed keywords

CYCLIN A; CYCLIN D1; CYCLIN E; ESTROGEN RECEPTOR; PERILLYL ALCOHOL; PROTEIN P21; PROTEIN P53; TERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN KPL 1; CELL STRAIN MCF 7; CELL STRAIN MDA MB 231; CELL STRAIN MKL F; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE METASTASIS; METASTASIS; MOUSE; NONHUMAN; NUDE MOUSE; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE; CYCLINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFUSIONS, PARENTERAL; MICE; MICE, NUDE; MONOTERPENES; NEOPLASM METASTASIS; PROLIFERATING CELL NUCLEAR ANTIGEN; RECEPTORS, ESTROGEN; TUMOR CELLS, CULTURED;

EID: 1842482587     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:BREA.0000019966.97011.4d     Document Type: Article

References (33)

1. Crowell PL, Siar Ayoubi A, Burke YD: Antitumorigenic effects of limonene and perillyl alcohol against pancreatic and breast cancer. Adv Exp Med Biol 401: 131-136, 1996
2. Elegbede JA, Elson CE, Qureshi A, Tanner MA, Gould MN: Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene. Carcinogenesis 5: 661-664, 1984
3. Elson CE, Maltzman TH, Boston JL, Tanner MA, Gould MN: Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis. Carcinogenesis 9: 331-332, 1988
4. Maltzman TH, Hurt LH, Elson CE, Tanner MA, Gould MN: The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil. Carcinogenesis 10: 781-783, 1989
5. Gould MN: Prevention and therapy of mammary cancer by monoterpenes. J Cell Biochem Suppl 22: 139-144, 1995
6. Haag JD, Lindstrom MJ, Gould MN: Limonene-induced regression of mammary carcinomas. Cancer Res 52: 4021-4026, 1992
7. Simonsen JL, Owen LN: The Terpenes. Vol. 1, Cambridge University Press, London, 1953
8. Haag JD, Gould MN: Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene. Cancer Chemother Pharmacol 34: 477-483, 1994
9. Crowell PL: Monoterpenes in breast cancer chemoprevention. Breast Cancer Res Treat 46: 191-197, 1997
10. Lantry LE, Zhang Z, Gao F, Crist KA, Wang Y, Kelloff GJ, Lubet RA, You M: Chemopreventive effect of perillyl alcohol on 4-(methylnitrosoamino)-1-(3- pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung. J Cell Biochem Suppl 27: 20-25, 1997
11. Reddy BS, Wang CX, Samaha H, Lubet R, Steele VE, Kelloff GJ, Rao CV: Chemoprevention of colon carcinogenesis by dietary perillyl alcohol. Cancer Res 57: 420-425, 1997
12. Mills JJ, Chari RS, Boyer IJ, Gould MN, Jirtle RL: Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. Cancer Res 55: 979-983, 1995
13. Stark MJ, Burke YD, McKinzie JH, Ayoubi AS, Crowell PL: Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol. Cancer Lett 96: 15-21, 1995
14. Belanger JT: Perillyl alcohol: applications in oncology. Altern Med Rev 3: 448-457, 1998
15. Shi W, Gould MN: Induction of cytostasis in mammary carcinoma cells treated with the anticancer agent perillyl alcohol. Carcinogenesis 23: 131-142, 2002
16. Bardon S, Picard K, Martel P: Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 expression in human breast cancer cell lines. Nutr Cancer 32: 1-7, 1998
17. Ariazi EA, Satomi Y, Ellis MJ, Haag JD, Shi W, Sattler CA, Gould MN: Activation of the transforming growth factor β signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. Cancer Res 59: 1917-1928, 1999
18. Crowell PL, Chang RR, Ren Z, Elson CE, Gould MN: Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites. J Biol Chem 266: 17679-17685, 1991
19. Kurebayashi J, Kurosumi M, Sonoo H: A new human breast cancer cell line, KPL-1, secretes tumor-associated antigens and grows rapidly in female athymic nude mice. Br J Cancer 71: 845-853, 1995
20. Soule HD, Vazguez J, Long A, Albert S, Brennan M: A human cell line from a pleural effusion derived from a breast carcinoma. J Natl Cancer Inst 51: 1409-1416, 1973
21. McLeskey SW, Zhang L, Kharbanda S, Kurebayashi J, Lippman ME, Dickson RB, Kern FG: Fibroblast growth factor overexpressing breast carcinoma cells as models of angiogenesis and metastasis. Breast Cancer Res Treat 39: 103-117, 1996
22. Cailleau R, Young R, Olive M, Reeves Jr WJ: Breast tumor cell lines from pleural effusions. J Natl Cancer Inst 53: 661-674, 1974
23. Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB: Evaluation of a tetrazolium-based semiautomated colonmetric assay: assessment of chemosensitivity testing. Cancer Res 47: 936-942, 1987
24. Geran RI, Greenberg NH, MacDonald MM, Schumacher AM, Abbott BJ: Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemother Rep 3: 1-103, 1972
25. Labat-Moleur F, Guillermet C, Lorimier P, Robert C, Lantuejoul S, Brambilla E, Negoescu A: TUNEL apoptotic cell detection in tissue sections: critical evaluation and improvement. J Histochem Cytochem 46: 327-334, 1998
26. Ripple GH, Gould MN, Arzoomanian RZ, Alberti D, Feierabend C, Simon K, Binger K, Tutsch KD, Pomplun M, Wahamaki A, Marnocha R, Wilding G, Bailey HH: Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day. Clin Cancer Res 6: 390-396, 2000
27. Sherr CJ: G1 phase progression: cyclin on cue. Cell 79: 551-555, 1994
28. Jacks T, Weinberg RA: Cell-cycle control and its watchman. Nature 381: 643-644, 1996
29. Sherr CJ, Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13: 1501-1512, 1999
30. Cayrol C, Knibiehler M, Ducommun B: p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. Oncogene 16: 311-320, 1998
31. Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G: Cyclin A is required at two points in the human cell cycle. EMBO J 11: 961-971, 1992
32. Bardon S, Foussard V, Fournel S, Loubat A: Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. Cancer Lett 181: 187-194, 2002
33. Lluria-Prevatt M, Morreale J, Gregus J, Alberts DS, Kaper F, Giaccia A, Powell MB: Effects of perillyl alcohol on melanoma in the TPras mouse model. Cancer Epidemiol Biomarkers Prev 11: 573-579, 2002