Sexual functioning in cancer patients

Sexuality and Disability

Volumn 20, Issue 4, 2002, Pages 277-295

  Monga, Uma ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Radiotherapy Service   (United States)

Author keywords

Cancer; Infertility; Pregnancy; Sexual functioning

Indexed keywords

BLEOMYCIN; BUSERELIN; CHLORMETHINE; CISPLATIN; CYCLOPHOSPHAMIDE; ESTROGEN; FOLLITROPIN; GONADORELIN; GONADORELIN DERIVATIVE; LUTEINIZING HORMONE; PREDNISONE; PROCARBAZINE; PROGESTERONE; TESTOSTERONE; VINBLASTINE; VINCRISTINE;

AZOOSPERMIA; CANCER CHEMOTHERAPY; CANCER HORMONE THERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURGERY; COLON CANCER; CYSTECTOMY; DYSPAREUNIA; EJACULATION DISORDER; ERECTILE DYSFUNCTION; FAMILY COUNSELING; HODGKIN DISEASE; HUMAN; INFERTILITY; LIBIDO DISORDER; LYMPH NODE DISSECTION; ORCHIECTOMY; ORGASM DISORDER; OVARY CANCER; OVARY INSUFFICIENCY; PARASYMPATHETIC INNERVATION; PATIENT EDUCATION; PLASTIC SURGERY; PRACTICE GUIDELINE; PSYCHOSOCIAL DISORDER; RADICAL HYSTERECTOMY; RECTUM CANCER; REVIEW; SEXUAL DYSFUNCTION; SEXUAL FUNCTION; TESTIS ATROPHY; TESTIS CANCER; TREATMENT OUTCOME; UTERINE CERVIX CANCER; UTERUS CANCER; VAGINA CANCER; VULVECTOMY;

EID: 1842479985     PISSN: 01461044     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021609530248     Document Type: Review

References (131)

1. Monga U: Sexuality in Cancer Patients. In: Sexuality and Disability, State of the Art Reviews: Physical Medicine and Rehabilitation. Philadelphia, Hanley & Belfus, 9:2:417-442,1995.
2. Derogatis L, Kourlesis SM,: An approach to evaluation of sexual problems in cancer patient Ca A Cancer J Clinics 31:46-50,1981.
3. Gulp DA, Graf RA, Hasctek H: Testicular tumor. J Urol 89:843-850,1963.
4. Sabri S, Cotton LT: Sexual function following aortoiliac reconstruction. Lancet 2:1218-1219,1971.
5. Whitelaw GP, Smithwick RH: Some secondary effects of sympathectomy with particular reference to disturbance of sexual function. New Eng J Med 245:121-130,1951.
6. Leiter E, Brendler H: Loss of ejaculation following bilateral retroperitoneal lymphadenectomy. J Urol 98:375-378,1967.
7. Tavel FR, Osius TG, Parker JW, Goodfriend RB, McGonigle DJ, Jassie MP, Simmons EL, Tobenkin MI, Schulte JW: Retroperitoneal lymph node dissection J Urol 89:241-245,1963.
8. Balslev I, Harling H: Sexual dysfunction following operation of carcinoma of the rectum. Dis Colon Rectum 26:785-788,1983.
9. La Monica G, Audisio RA, Tamburini M, et al Incidence of sexual dysfunction in male patients treated surgically for rectal malignancy. Dis Colon Rectum 28:937-940,1985.
10. Santangelo ML, Romano G, Sassaroli C: Sexual function after resection for rectal cancer. Am J Surg 154:502-504,1987.
11. Koukouras D, Spiliotis J, Scopa CD, Kalfarenztos F, Tzoracoleftherakis E, Androulakis J: Radical consequences in the sexuality of male patients operated for colorectal carcinoma Eur J Surg Oncol 17:285-288,1991.
12. Tomoda H, Furosawa M: Sexual and urinary dysfunction following surgery for sigmoid colon cancer. Jpn J Surg 15:355-360,1985.
13. Yeager SE, Van Heerden JA: Sexual dysfunction following proctocolectomy and abdominoperineal resection. Ann Surg 191:169-170,1980.
14. Nazareth I, Lewin J, King M: Sexual dysfunction after treatment for testicular cancer: a systematic review. J Psychosom Res 51:735-743,2001.
15. Jonker-Pool G, Van de Wiel HB, Hoekstra HJ, et al., Sexual functioning after treatment for testicular cancer-review and meta-analysis of 36 emperical studies between 1975-2000. Arch Sex Behav 30:55-74,2001.
16. Bloom JR, Fobair P, Gritz E, Wellisch D, et al., Psychosocial outcomes of cancer: a comparative analysis of Hodgkin's disease and testicular cancer. J Clin Oncol 11:979-988,1993.
17. Gritz ER, Wellisch DK, Wang HJ, et al., Long term effects of testicular cancer on sexual functioning in married couples. Cancer 64:1560,1989.
18. Grossfeld GD, Small EJ: Long-term side effects of treatment for testis cancer. Urol Clin North Am 25:503-515,1998.
19. Schover LR, von Eschenbach AC: Sexual and marital relationships after treatment for non-seminomatous testicular cancer. Urology 25:251-255,1985.
20. Donohue JP, Foster RS, Rowland RG, et al.: Nerve sparing retroperitoneal lymphadenectomy with preservation of ejaculation. J Urol 144:287-292,1990.
21. Jewett MAS, Kong YP, Godberg SD, et al: Retroperitoneal lymphadenectomy for testis tumor with nerve sparing for ejaculation. J Urol 139:1220-1224,1988.1
22. Schover LR, von Eschenbach AC: Sexual and marital relationships after treatment for non-seminomatous testicular cancer. Urology 25:251-255,1985.
23. Coogan CL, Hejase MJ, Wahle GR, et al., Nerve sparing post-chemotherapy retroperitoneal lymph node dissection for advanced testicular cancer. J Urol 156:1656-1658,1996.
24. Jonker-Pool G, van Basten JP, Hoekstra HJ, et al., Sexual functioning after treatment for testicular cancer: comparison of treatment modalities. Cancer 80:454-464,1997.
25. Bachers ES: Sexual dysfunction after treatment for genitourinary cancers Sem One Nsg 1:18-24,1985.
26. Schover LR, Evans RB, von Eschenbach AC: Sexual rehabilitation and male radical cystectomy J Urol 136:1015-1017,1986.
27. Henningsohn L, Steven K, Kallestrup EB, Steineck G: Distressful symptoms and well being after radical cystectom and orthotopic bladder substitution compared with a matched control population. J Urol 168:168-174,2002.
28. Hurny C, Holland JC: Psychosocial sequelae of ostomies in cancer patients. CA 36:170-183,1985.
29. Walsh PC, Schlegel PN: Radical pelvic surgery with preservation of sexual function. Ann Surg 208:391-400,1988.
30. Andersen BL: Sexual functioning morbidity among cancer survivors. Current status and future research directions. Cancer 55:1835-1842,1985.
31. Andersen BL, Andersen B, deProsse C: Controlled prospective longitudinal study of women with cancer:I Sexual functioning outcomes J Consult Clin Psychol 57:683-691,1989a.
32. Andersen BL, Andersen B, deProsse C: Controlled prospective longitudinal study of women with cancer:II. Psychological outcomes. J Consult Clin Psychol 57:692-697,1989b.
33. Lalos O, Lalos A: Urinary, climateric and sexual symptoms one year after treatment of endometrial and cervical cancer. Eur J Gynaecol Oncol 17:128-136,1996.
34. Schover LR, Fife M, Gershenson DM: Sexual dysfunction and treatment for early cervical cancer. Cancer 63:204-212,1989.
35. Vincent CE, Vincent B, Greiss FC, Linton EB: Some marital sexual concomitants of carcinoma of the cervix. South Med J 68:52-58,1975.
36. Flay LD, Matthews JH: The effects of radiotherapy and surgery on the sexual function of women treated for cervical cancer. Int J Radiat Oncol Biol Phys 31:399-404,1995.
37. Seibel MM, Freeman MM, Graves WL: Carcinoma of the cervix and sexual function. Obstetrics and Gynecology 55:484-487,1980.
38. Andreasson B, Moth J, Jensen SB, Bock JE: Sexual function and somatopsychic reactions in vulvectomy-operated women and their partners. Acta Obstet Gynecol Scand 65:7-10,1986.
39. Andersen BL, Hacker NF: Psychosexual adjustment after vulvar surgery. Obstet Gynecol 62:457-462,1983.
40. Moth I, Andreasson B, Soren BJ, Bock JE: Sexual function and somatopsychic reactions after vulvectomy. Danish Medical Bulletin 30:27-34,1983.
41. Weijmar Schultz WCM, van de Wiel HBM, Bouma J, Janssens J, Littlewood J: Psychosocial functioning after the treatment of cancer of the vulva. Cancer 66:402-407,1990.
42. Stellman RE, Goodwill JM, Robinson J, Dansak D, Hilgers RD: Psychological effects of vulvectomy. Psychosomatics 25:779-783,1984.
43. Breitbart W, Holland J: Psychosocial aspects of head and neck cancer. Semin Oncol 15:61-69,1988.
44. Dropkin MJ: Coping with disfigurement and dysfunction after head and neck cancer surgery: a conceptual framework. Semin Oncol Nurs 5:213-219,1989.
45. Koster META, Bersman J: Problems and coping behavior of facial cancer patients. Soc Sci Med 5:569-578,1990.
46. Bolund G: Suicide and cancer II: Medical and care factors in suicide by cancer patients in Sweden. J Psychosoc Oncol 3:31-52,1985.
47. Hientanen P, Lonnqvist J: Cancer and suicide. Ann Oncol 2:19-23,1991.
48. Gamba A, Romano M, Grasso IM, Tamburini M, Cantu G, Molinari R, Ventafridda V: Psychsocial adjustment of patients surgically treated for head and neck cancer. Head and Neck May/June 218-223,1992.
49. Dhillon RS, Palmer BV, Pittam MR, Shaw HJ: Rehabilitation after major head and neck surgery-the patients view Clin Otolaryngol 7:319-324,1982.
50. Monga U, Tan G, Ostermann HJ, Monga TN: Sexuality in Head and Neck Cancer Patients. Arch Phys Med Rehabil 78:298-303,1996.
51. Derogatis L, Kourlesis SM: An approach to evaluation of sexual problems in cancer patient Ca A Cancer J Clinics 31:46-50,1981.
52. Dropkin MJ: Coping with disfigurement and dysfunction after head and neck cancer surgery: a conceptual framework. Semin Oncol Nurs 5:213-219,1989.
53. Ofman US, Auchincloss SS: Sexual dysfunction in cancer patients. Current Opinion in Oncol 4:605-613,1992.
54. Sutherland AM, Orbach CE, Dyk RB, Bard M: The psychological impact of cancer surgery: I. adaptation to the dry colostomy: preliminary report and summary of findings. Cancer 5:857-872,1952.
55. Gloeckner MR, Startling JR: Providing sexual information to ostomy patients Dis Colon Rectum 25:575-579,1982.
56. Nilsson LO, Kock NG, Kylberg F, Myrvold HE, Palsclius I: Sexual adjustment in ileostomy patients before and after conversion to continent ileostomy. Dis Col Rect 24:287-290,1981.
57. Bagshaw MA, Cox RS, Ray GR: Status of radiation treatment of prostate cancer at Stanford University. NCI Mongr. 7:47-60,1988.
58. Banker FL: The preservation of potency after external beam radiation for prostate cancer. 15:219-220,1988.
59. van Heeringen C, De Schryver A, Verbeek E: Sexual function disorders after local radiotherapy for carcinoma of the prostate. Radiother Oncol 13:47-52,1988.
60. Zinreich ES, Derogatis LR, Herpst J, Auvil G, Paintadosi S, Order SE: Pretreatment evaluation of sexual function in patients with adenocarcinoma of the prostate. Int J Radiat Oncol Biol Phys 19:1001-1004,1990.
61. Hussey DH: The Testicle: In Moss' Radiation Oncolgy James D Cox ED. St Louis, 1994.
62. Rowley MJ, Leach DR, Warner GA, Heller CG: Effect of graded doses of ionizing radiation on the human testis. Radiat Res 59:665-675,1974.
63. Zuckerman S: The sensitivity of the gonads to radiation. Clin Radiol 26:1-15,1965.
64. Gordon W, Siegmund K, Stanisic TH, et al., A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711) Southwest Oncology Group. Int J Radiat Oncol Biol Phys 38:83-94,1997.
65. Fossa SD, Horwich A, Russell JM, et al., Optimal planning target volume for stage I testicular seminima: A medical Research Council randomized trial. Medical Rsearch Council Testicular Tumor Working Group. J Clin Oncol 17:1146,1999.
66. Glucksmann A: The effects of radiation on reproductive organs. Br J Radiol 20(suppl 1):101-109,1947.
67. Lushbaugh CC, Ricks RC: Some cytokinetic and histopathological considerations of irradiated male and female gonadal tissues Front Radiat Ther One 6:228-248,1972.
68. Ash P: The influence of radiation on fertility in man. Brit J Rad 53:271-1980.
69. Hahn EW, Feingold SM, Simpson L et al. Recovery from aspermia induced by low dose radiation in seminoma patients. Cancer 50:337-340,1980.
70. Buchanan JD, Fairley KF, Barrie JU: Return of spermatogenesis after stopping cyclophosphamide therapy. Lancet 2:156-157,1975.
71. Cheviakoff S, Calmera JC, Morgenfeld M, Mancini RE: Recovery of spermatogenesis in patients with lymphoma after treatment with chlorambucil J Reprod Peril 33:155,1973.
72. Slanina J: Long term side effects of irradiation in patients with Hodgkin's disease. Int J Rad Oncol Biol Phys 2:1-1977.
73. Shamberger RC, Sherins RJ, Rosenberg SA: The effects of postoperative adjunct chemotherapy and radiotherapy on testicular function in men undergoing treatment for soft tissue sarcoma. Cancer 47:2368-2374,1981.
74. Million RR: The lymphomatous disease, In Fletcher GH, ed. Textbook of Radiotherapy, Philadelphia, Lea & Febiger, 1980.
75. Tomic R, Bergman B, Damber JE, Littbrand B, Lofroth: Effects of external radiation therapy for cancer of the prostate on the serum concentration of testosterone, follicle stimulating hormone, luteinizing hormone and prolactin. 130:287-289,1983.
76. Schover LR, Montague DK, Schain WS: Sexual problems. In DeVita VT, Hellman S, Rosenberg SA (eds): Cancer Principles and Practice of Oncology. JB Lippincott Company 1993, pp 2467.
77. Bracken RB, Smith KD: Is semen cropreservation helpful in testicular cancer. Urology 15:581,1980.
78. Chapman RM, Sutcliffe SB, Malpas JS: Male gonadal dysfunction in Hodgkin's disease. JAMA 245:1323-1328,1981.
79. Redman JR, Bajorunas DR, Golsrein MC, et al. Semen cryopreservation and artificial insemination for Hodgkin's disease. J Clin Oncol 5:233-238,1987.
80. Sanger WG, Armitage JO, Schmidt MA: Feasibility of semen cryopreservation in patients with malignant disease. JAMA 244:789-790,1980.
81. Thachil JV, Jewett MAS, Ridder WD: The effects of cancer and cancer therapy on male fertility. J Urology 126:141-145,1981.
82. Adelusi B: Coital function after radiotherapy for carcinoma of the cervix uteri. Br J Gynaecol 87:821-823,1980.
83. Peck WS, McGreer JT, Kretschmar NR et al. Castration of the female by irradiation. Radiology 34:176-186,1940.
84. Qureshi MS, Pennington JH, Goldsmith HJ, et al.: Cyclophosphamide therapy and sterility. Lancet 2:1290-1291,1972.
85. Chapman RM, Sutcliffe, SB, Rees LH, et al.: Cyclical combination and gonadal function: Retrospective study in males. Lancet 1:265-269,1979.
86. Chapman RM, Sutcliffe SB, Rees L, et al. Prospective study: The effects of Hodgkin's disease and nitrogen mustard, vincristine, procarbazine and prednisolone on male gonadal function. Proc Am Soc Clin Oncol 20:321-,1979.
87. Kreuser ED, Hetzel WD, Heit W, et al.: Reproductive and endocrine gonad functions in adults following multidrug chemotherapy for acute lymphoblastic or undifferentiated leukemia. J Clin Oncol 6:588-595,1988.
88. Vivani S, Santoro A, Ragri G, et al: Gonadal toxicity after combination chemotherapy for Hodgkin's disease: Comparative results of MOPP vs ABVD. Eur J Cancer Clin Oncol 21:601-605,1985.
89. Miller JJ, Williams GF, Leissring JC: Multiple late complications of therapy with cyclophosphamide including ovarian destruction. Am J Med 50:530-535,1971.
90. Richter P, Calamera JC, Morgenfeld MC, et al.: Effects of chlorambucil on spermatogenesis in the human with malignant lymphoma. Cancer 25:1026-1030,1970.
91. Cheviakoff S, Calmera JC, Morgenfeld M, Mancini RE: Recovery of spermatogenesis in patients with lymphoma after treatment with chlorambucil J Reprod Peril 33:155,1973.
92. Sherins RJ, DeVita VT Jr: Effect of drug treatment for lymphoma on male reproductive capacity. Studies of men in remission after therapy. Ann Intern Med 79:216-220,1973.
93. Drasga RE, Einhora LH, Williams SD, et al., Fertility after chemotherapy for testicular cancer J Clin Oncol 1:179-183,1983.
94. Kreuser ED, Harsch U, Hetzel WD, Schreml W: Chronic gonadal toxicity in patients with testicular cancer after chemotherapy. Eup J Cancer Clin Oncol 22:289-294,1986.
95. Andrieu JM, Ochoa-Molina ME: Menstrual cycle, pregnancies and offspring before and after MOPP therapy for Hodgkin's disease. Cancer 52:435-438,1983.
96. Chapman RM, Sutcliffe SB, Malpas JS: Cytotoxic induced ovarian failure in women with Hodgkin's disease. I. Hormone function JAMA 242:1877-1881,1979.
97. Gershenson DM: Menstrual and reproductive function after treatment with combination chemotherapy for malignant ovarian germ cell tumors. J Clin Oncol 6:270-275,1988.
98. Rose DP, Davis TE: Ovarian function in patients receiving adjunct chemotherapy for breast cancer. Lancet 1:1174-1176,1977.
99. Warne GL, Fairley KF, Hobbs JB, et al.: Cyclophosphamide induced ovarian failure. N Engl J Med 289:1159-1162,1973.
100. Whitehead E, Shalet SM, Blackledge G, et al. The effect of combination chemotherapy on ovarian function in women treated for Hodgkin's disease. Cancer 52:988-993,1983.
101. Sobrinho LG, Levine RA, DeConti RC: Amenorrhea in patients with Hodgkin's disease treated with antineoplastic agents. Am J Obstet Gynecol 109:135-139,1971.
102. Li FP, Fine W, Jaffe N, et al.: Offspring of patients treated for cancer in childhood. J Natl Cancer Inst 62:1193-1197,1979.
103. Ross GT: Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms. Cancer 37:1043-1047,1976.
104. Van Thiel DH, Ross GT, Lipsett MB: Pregnancies after chemotherapy of trophoblastic neoplasms. Science 169:1326-1327,1970.
105. Schover LR: Sexuality and fertility in urologie cancer patients. Cancer 60:553-558,1987.
106. Peeling WB: Phase III studies to compare goserelin with orchiectomy and with diethylstilbestrol in treatment of prostatic carcinoma. Urology (Suppl) 33:45-52,1989.
107. Monga U, Garber S, Kerrigan AJ, Monga TN: Pre-and Post-Radiotherapy Sexual Functioning in Prostate Cancer Patients. Sexuality and Disability 19:239-252,2002.
108. Trimbos JB, Mass CP, Deruiter MC, Peters AA, Kenter GG: Int J Gynecol Cancer 11:180-186,2000.
109. Nature Medicine 7:1073-1074,2001.
110. Kedia S, Zippe CD, Agarwal A, Nelson DR, Lakin MM: Treatment of erectile dysfunction with Sildenafil citrate (Viagra) after radiation therapy for prostate cancer. Urology 54:308-312,1999.
111. Incrocci L, Koper PC, Hop WC, Slob AK: Sildenafil citrate (Viagra) and erectile dysfunction following external beam radiotherapy for prostate cancer: a randomized, double-blind, placebo-controlled, cross-over study. Int J Radiat Oncol Biol Phys 51:1190-1195,2001.
112. Baniel J, Israilov S, Segenreich E, Livne PM: Comparative evaluation of treatments for erectile dysfunction in patients with prostate cancer after radical retropubic prostatectomy. BJU Int 88:58-62,2001.
113. Valicenti RK, Choi E, Chen C, Lu JD, Hirsch IH, Mulholland GS et al., Sildenafil citrate effectively reverses sexual dysfunction induced three-dimensional conformal radiation therapy. Urology 57:769-737,2001.
114. Paige NM, Hays RD, Litwin MS, Rajfer J, Shapiro MF: Improvement in emotional well-being and relationships of users of Sildenafil. J Urol 166:1774-1778,2001.
115. Dupont WD, Page DL: Menopausal estrogen replacement therapy and breast cancer. Arch Intern Med 151:67-72,1991.
116. Monga U, Beyond Intercourse: An alternative perspective on sexual function (commentary), Contemporary Urology April 1999.
117. Schover LR, Evans RB, von Eschenbach AC: Sexual rehabilitation in a cancer center: Diagnosis and outcome in 384 consultations. Arch Sex Behav 16:445-461,1987.
118. Tan G, Monga U, Thornby J, Monga TN: Sexual Functioning - Age, and Depression Revisited. Sexuality and Disability 77-86, 1998.
119. Schover LR. Randers-Pehrson M: Sexuality and cancer - For the women who have cancer and her partner. Atlanta; American Cancer Society, 1991.
120. Schover LR, Randers-Pehrson M: Sexuality and cancer - For the men who have cancer and his partner. Atlanta; American Cancer Society, 1991.
121. Gibbons W: In-vitro fertilization as therapy for male factor infertility. Urol Clin N Am 14:563-567,1987.
122. Scammell GE, White N, Stedronska J, et al.: Cryopreservation of semen in men with testicular tumor or Hodgkin's disease: Results of artificial insemination of their partners. Lancet 2:31-32,1985.
123. Redman JR, Bajorunas DR, Golsrein MC, et al. Semen cryopreservation and artificial insemination for Hodgkin's disease. J Clin Oncol 5:233-238,1987.
124. Reed E, Sanger WG, Armitage JO: Results of semen cryopreservation in young men with testicular carcinoma and lymphoma. J Clin Oncol 4:537-539,1986.
125. Hatch KD: Neovaginal reconstruction. Cancer Supp. 71:1660-1663,1992.
126. Morley GW, Lindenauer SM, Youngs D: Vaginal reconstruction following pelvic exenteration: Surgical and psychological considerations. Am J Obstet Gynecol 116:996-1002,1973.
127. Vera MI: Quality of life following pelvic exenteration. Gynecol Oncol 12:355-366,1981.
128. Bertani A, Riccio, Belligolli A: Vuvlar reconstruction after cancer excision: the island groin flap technique. Br J Plastic Surgery 43:159-161,1990.
129. Hurwitz DJ, Zwiebel PC: Gluteal thigh flap repair of chronic perineal wounds. Am J Surg 150:386-391,1985.
130. Rutledge F, Sinclair M: Treatment of intraepithelial carcinoma of the vulva by skin excision and graft. Am J Obstet Gynecol 102:807-811,1968.
131. Fordney DS: Dyspareunia and vaginismus. Clin Obstet Gynecol 21:205-221,1978.