Nodular Regenerative Hyperplasia of the Liver: An under-recognized Cause of Portal Hypertension in Hematological Disorders

American Journal of Hematology

Volumn 75, Issue 4, 2004, Pages 225-230

  Al Mukhaizeem, Khalid A ^a,b   Rosenberg, Arthur ^a   Sherker, Averell H ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b AL AMIRI HOSPITAL   (Kuwait)

^c WASHINGTON HOSPITAL CENTER   (United States)

Author keywords

Liver; Nodular regenerative hyperplasia; Portal hypertension

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; NADOLOL; PROPRANOLOL; SOMATOSTATIN; SOMATOSTATIN DERIVATIVE;

BLOOD DYSCRASIA; CLINICAL FEATURE; COLLAGEN DISEASE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DISEASE COURSE; ENDOSCOPIC SCLEROTHERAPY; ESOPHAGUS VARICES BLEEDING; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL HEMORRHAGE; HEMATOLOGIC DISEASE; HEMATOLOGIC MALIGNANCY; HUMAN; LIVER BLOOD FLOW; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FIBROSIS; LIVER FUNCTION; LIVER HYPERPLASIA; LIVER SINUSOID; LYMPHOPROLIFERATIVE DISEASE; MYELOPROLIFERATIVE DISORDER; PATHOGENESIS; PORTAL HYPERTENSION; PORTOSYSTEMIC ANASTOMOSIS; PRIORITY JOURNAL; SHORT SURVEY; VASCULAR DISEASE;

DIAGNOSIS, DIFFERENTIAL; FOCAL NODULAR HYPERPLASIA; HEMATOLOGIC DISEASES; HYPERTENSION, PORTAL; LIVER REGENERATION;

EID: 1842479432     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.20024     Document Type: Short Survey

References (28)

1. Shaldon S, Sherlock S. Portal hypertension in the myeloproliferative syndrome and reticuloses. Am J Med 1962;32:758.
2. Stromeyer F, Ishak K. Nodular transformation (nodular "regenerative" hyperplasia) of the liver. Hum Pathol 1981;12:60-71.
3. Rosen A, Iseri O, Fishbein G, Knodell R. Nodular regenerative hyperplasia: a cause of ascites and hepatomegaly after chemotherapy for leukemia. Am J Gastroenterol 1991;86:86-88.
4. Al-Mukhaizeem KA, Lamoureux E, Rosenberg A, Sherker AH. Nodular regenerative hyperplasia of the liver and focal global glomerulosclerosis associated with sickle cell anemia. Dig Dis Sci 2002;47:443-447.
5. Ranstrom S. Miliary hepatocellular adenomatosis. Acta Pathol Microbiol Scand 1953;33:225-229.
6. Steiner P. Nodular regenerative hyperplasia of the liver. Am J Pathol 1959;35:943.
7. Blendis L, Parkinson M, Shilkin K, Williams R. Nodular regenerative hyperplasia of the liver in Felty's syndrome. Q J Med 1974; 43:25.
8. Wanless IR. Micronodular transformation (nodular regenerative hyperplasia) of the liver: a report of 64 cases among 2,500 autopsies and a new classification of benign hepatocellular nodules. Hepatology 1990;11:787-797.
9. Moran C, Mullick F, Ishak K. Nodular regenerative hyperplasia of the liver in children. Am J Surg Pathol 1991;15:449-454.
10. Nakanuma Y, Hoso M, Sasaki M, et al. Histopathology of the liver in non-cirrhotic portal hypertension of unknown aetiology. Histopathology 1996;28:195-204.
11. Rous P, Larimore L. Relation of the portal blood flow to liver maintenance. J Exp Med 1920;31:609.
12. Shimamatsu K, Wanless IR. Role of ischemia in causing apoptosis, atrophy, and nodular hyperplasia in human liver. Hepatology 1997;26:343-350.
13. Wanless IR, Godwin TA, Allen F, Feder A. Nodular regenerative hyperplasia of the liver in hematologic disorders: a possible response to obliterative portal venopathy. A morphometric study of nine cases with an hypothesis on the pathogenesis. Medicine 1980; 59:367-379.
14. Goritsas C, Repanti M, Papadaki E, Lazarou N, Andonopoulos A. Intrahepatic bile duct injury and nodular regenerative hyperplasia of the liver in a patient with polyarteritis nodosa. J Hepatol 1997;26.
15. McDonald J, Painter DM, Gallagher ND, McCaughan GW, Nodular regenerative hyperplasia mimicking cirrhosis of the liver. Gut 1990;31:725-727.
16. Kingham J, Levison D, Stansfeld A, Dawson A. Non-cirrhotic intrahepatic portal hypertension: a long-term follow-up study. Q J Med 1981;199:259-268.
17. Portmann B, Stewart S, Higenbottam T, Clayton P, Lloyd J, Williams R. Nodular transformation of the liver associated with portal and pulmonary arterial hypertension. Gastroenterology 1993;104:616-621.
18. Diaz de Otazu R, Garcia-Campos F, Basterra G, Lopez-Barbarin J. Nodular regenerative hyperplasia and focal nodular hyperplasia of the liver associated with severe cholestasis. Report of a case with autopsy findings. Liver 1986;6:30-34.
19. International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995;22:983-993.
20. Nzeako U, Goodman Z, Ishak K. Hepatocellular carcinoma and nodular regenerative hyperplasia: possible pathogenetic relationship. Am J Gastroenterol 1996;91:879-884.
21. Groszmann R, Atterbury C. Clinical applications of the measurement of portal venous pressure. Stud Clin Liver Dis 1980;2:379-386.
22. Ueno S, Tanabe G, Sueyoshi K, et al. Hepatic hemodynamics in a patient with nodular regenerative hyperplasia. Am J Gastroenterol 1996;91:1012-1015.
23. Dachman AH, Ros PR, Goodman ZD, Olmsted WW, Ishak KG. Nodular regenerative hyperplasia of the liver: clinical and radiologic observations. Am J Roentgenol 1987;148:717-722.
24. Siegelman ES, Outwater EK, Furth EE, Rubin R. MR imaging of hepatic nodular regenerative hyperplasia. J Magn Reson Imaging 1995;5:730-732.
25. Cano-Ruiz A, Martin-Scapa MA, Larraona JL, Gonzalez-Martin JA, Moreno-Caparros A, Garcia-Plaza A. Laparoscopic findings in seven patients with nodular regenerative hyperplasia of the liver. Am J Gastroenterol 1985;80:796-800.
26. Solis Herruzo JA, Duran A, Colina F, et al. Laparoscopic and histological problems in the diagnosis of nodular regenerative hyperplasia of the liver. Endoscopy 1985;17:105-108.
27. Pagliaro L, D'Amico G, Sorensen TI, al. Prevention of first bleeding in cirrhosis. A meta-analysis of randomized trials of nonsurgical treatment, Ann Intern Med 1992;117:59-70.
28. Elariny HA, Mizrahi SS, Hayes DH, Boudreaux JP, Hussey JL, Farr GH Jr. Nodular regenerative hyperplasia: a controversial indication for orthotopic liver transplantation. Transplant Int 1994;7:309-313.