Methadone and QT prolongation: A dose-dependent effect?

American Journal of Cardiology

Volumn 93, Issue 7, 2004, Pages 952-

  Krantz, Mori J ^a   Mehler, Philip S ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

METHADONE;

CHRONIC PAIN; CLINICAL TRIAL; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG SAFETY; HEART REPOLARIZATION; HUMAN; NOTE; OPIATE ADDICTION; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; STATISTICAL SIGNIFICANCE; TORSADE DES POINTES;

EID: 1842476934     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2003.11.066     Document Type: Letter

References (5)

1. Gil M., Sala M., Anguera I., Chapinal O., Cervantes M., Guma J.R., Segura F. QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone. Am J Cardiol. 92:2003;995-997.
2. Thompson K.A., Murray J.J., Blair I.A., Woosley R.L., Roden D.M. Plasma concentrations of quinidine, major metabolites, and dihydroquinidine in patients with Torsades de Pointes. Clin Pharmacol Ther. 43:1988;636-642.
3. Krantz M.J., Kutinsky H.B., Robertson A.D., Mehler P.S. Dose-related effects of methadone on QT prolongation in a series of patients with Torsade de Pointes. Pharmacotherapy. 23:2003;802-805.
4. Martell B.A., Ray B., Gourevitch M.N. The impact of methadone induction on cardiac conduction in opiate users. Ann Int Med. 139:2003;E-154-E-155.
5. Huber A., Ling W., Fradis J., Charuvastra V.C. Comparison of the effects of methadone and LAAM on the electrocardiogram. (abstr) Drug Alcohol Depend. 63:2001;S70.