Mitogenic signalling by insulin in a T-cell lymphoma, the LB cell line, devoid of IGF-I receptors: Evidence for the lack of involvement of the RAS-MAP kinase pathway and for a possibly novel IRS-like molecule

Experimental and Clinical Endocrinology and Diabetes

Volumn 104, Issue , 1996, Pages 52-53

  Urs⊘, Birgitte ^a   Christoffersen, Claus T ^a   Tornqvist, Hans ^a   De Meyts, Pierre ^a   Ouwens, Margriet ^b   Vlahos, Chris ^c   White, Morris ^d   Naor, David ^e  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b LEIDEN UNIVERSITY   (Netherlands)

^c ELI LILLY AND COMPANY   (United States)

^d JOSLIN DIABETES CENTER   (United States)

^e HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 1842470630     PISSN: 09477349     EISSN: 14393646     Source Type: Journal    
DOI: 10.1055/s-0029-1211533     Document Type: Article

References (5)

1. Ish-Shalom D, Tzivion G, Christoffersen CT, Urs⊘ B, De Meyts P, Naor D (1995). Mitogenic potential of insulin on lymphoma cells lacking IGF-I receptors. Ann. N. Y. Acad. Sci. 766: 409-415.
2. Schäffer, L (1994). A model for insulin binding to the insulin receptor. Eur. J. Biochem. 221: 1127-1132.
3. De Meyts P, (1994). The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling. Diabetologia 37: S 135-48.
4. Hondo MM, Damholdt A, Cunningham B, Wells JA, De Meys P, and Shymko RM (1994). Receptor dimerization determines the effect of growth hormone in primary rat adipocytes and cultured IM-9 lymphocytes. Endocrinology 134: 2397-2403.
5. De Meyts P, Urs⊘ B, Christoffersen CT, Shymko RM, (1995). Mechanism of insulin and IGF-I receptor activation and signal transduction specificity Receptor dimer cross-linking, bell-shaped curves, and sustained versus transient signaling. Ann. N. Y. Acad. Sci. 766: 388-401.