Connexin32-Containing Gap Junctions in Schwann Cells at the Internodal Zone of Partial Myelin Compaction and in Schmidt-Lanterman Incisures

Journal of Neuroscience

Volumn 24, Issue 13, 2004, Pages 3186-3198

  Meier, Carola ^a,b   Dermietzel, Rolf ^a   Davidson, Kimberly G V ^b   Yasumura, Thomas ^b   Rash, John E ^b  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Charcot Marie Tooth disease; Connexon; Freeze fracture; Immunogold labeling; Sciatic nerve; Tight junction

Indexed keywords

CONNEXIN 32; ION; MYELIN;

ANIMAL TISSUE; ARTICLE; CYTOPLASM; FEMALE; FREEZE FRACTURE; GAP JUNCTION; HEREDITARY MOTOR SENSORY NEUROPATHY; IMMUNOCYTOCHEMISTRY; IMMUNOGOLD LABELING; IMMUNOHISTOCHEMISTRY; ION TRANSPORT; MALE; MOUSE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; RANVIER NODE; SCHWANN CELL; SCIATIC NERVE; TIGHT JUNCTION; WATER TRANSPORT;

ANIMALS; CONNEXINS; FEMALE; FREEZE FRACTURING; GAP JUNCTIONS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELIN SHEATH; RANVIER'S NODES; SCHWANN CELLS; SCIATIC NERVE;

EID: 1842454157     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5146-03.2004     Document Type: Article

References (43)

1. Altevogt BM, Kleopa KA, Postma FR, Scherer SS, Paul DL (2002) Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems. J Neurosci 22:6458-6470.
2. Anzini P, Neuberg DH, Schachner M, Nelles E, Willecke K, Zielasek J, Toyka KV, Suter U, Martini R (1997) Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32. J Neurosci 17:4545-4551.
3. Balice-Gordon RJ, Bone LJ, Scherer SS (1998) Functional gap junctions in the Schwann cell myelin sheath. J Cell Biol 142:1095-1104.
4. Bergoffen J, Scherer SS, Wang S, Oronzi-Scott M, Bone L, Paul DL, Chen K, Lensch MW, Chance P, Fischbeck K (1993) Connexin mutations in X-linked Charcot-Marie-Tooth disease. Science 262:2039-2042.
5. Branton D, Bullivant S, Gilula NB, Karnovsky MJ, Moor H, Muhlethaler K, Northcote DH, Packer L, Satir B, Satir P, Speth V, Staehlin LA, Steere RL, Weinstein RS (1975) Freeze-etching nomenclature. Science 190:54-56.
6. Bunge MB, Bunge RP, Cochran ER (1978) Some factors influencing the proliferation and differentiation of myelin forming cells. Neurology 9:59-67.
7. Chandross KJ, Kessler JA, Cohen RI, Simburger E, Spray DC, Bieri P, Dermietzel R (1996) Altered connexin expression after peripheral nerve injury. Mol Cell Neurosci 7:501-518.
8. Chen YA, Scheller RH (2001) SNARE-mediated membrane fusion. Nat Rev Mol Cell Biol 2:98-106.
9. Dermietzel R, Schuenke D, Leibstein A (1978) The oligodendrocytic junctional complex. Cell Tiss Res 193:61-72.
10. Dinchuk JE, Johnson TJ, Rash JE (1987) Postreplication labeling of E-leaflet molecules: membrane immunoglobulins localized in sectioned, labeled replicas examined by TEM and HVEM. J Electron Microsc Tech 7:1-16.
11. Fujimoto K (1995) Freeze-fracture replica electron microscopy combined with SDS digestion for cytochemical labelling of integral membrane proteins. Application to the immunogold labelling of intercellular junctional complexes. J Cell Science 108:3443-3449.
12. Goodenough DA (1975) Methods for the isolation of and structural characterization of hepatocyte gap junctions. In: Methods in membrane biology, Chap 2, Vol III (Korn ED, ed), pp 51-80. New York: Plenum.
13. Kumar NM, Gilula N (1996) The gap junction communication channel. Cell 84:381-388.
14. Larsen WJ (1983) Biological implications of gap junction structure, distribution and composition: a review. Tissue Cell 15:645-671.
15. Li X, Lynn BD, Olson C, Meier C, Davidson KG, Yasumura T, Rash JE, Nagy JI (2002) Connexin29 expression, immunocytochemistry and freeze-fracture replica immunogold labelling (FRIL) in sciatic nerve. Eur J Neurosci 16:795-806.
16. Mambetisaeva FT, Gire V, Evans WH (1999) Multiple connexin expression in peripheral nerve, Schwann cells, and Schwannoma cells. J Neurosci Res 57:166-175.
17. Martini R, Schachner M (1997) Molecular bases of myelin formation as revealed by investigations on mice deficient in glial cell surface molecules. Glia 19:298-310.
18. Massa PT, Mugnaini E (1982) Cell junctions and intramembrane particles of astrocytes and oligodendrocytes: a freeze-fracture study. Neuroscience 7:523-538.
19. Mugnaini E, Osen KK, Schnapp B, Friedrich Jr VL (1977) Distribution of Schwann cell cytoplasm and plasmalemmal vesicles (caveolae) in peripheral myelin sheaths. An electron microscopic study with thin sections and freeze-fracturing. J Neurocytology 6:647-668.
20. Nagaoka T, Oyamada M, Okajima S, Takamatsu T (1999) Differential expression of gap junction proteins connexin26, 32, and 43 in normal and crush-injured rat sciatic nerves. Close relationship between connexin43 and occludin in the perineurium. J Histochem Cytochem 47:937-948.
21. Nelles E, Butzler C, Jung D, Temme A, Gabreil HD, Dahl U, Traub O, Stumpel F, Jungermann K, Zielasek J, Toyka K, Dermietzel R, Willecke K (1996) Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proc Natl Acad Sci USA 93:9565-9570.
22. Pereda A, O'Brien J, Nagy JI, Bukauskas F, Davidson KGV, Yasumura T, Rash J (2003) Connexin35 mediates electrical transmission at mixed synapses on Mauthner cells. J Neurosci 23:7489-7503.
23. Peters A, Palay SL, Webster HD (1991) The fine structure of the nervous system. Neurons and their supporting cells, Ed 3, pp 212-272. Oxford: Oxford UP.
24. Phillips TE, Boyne AF (1984) Liquid nitrogen-based quick freezing: experiments with bounce-free delivery of cholinergic nerve terminals to a metal surface. J Electron Micros Res 1:9-29.
25. Rash JE, Yasumura T (1999) Direct immunogold labeling of connexins and aquaporin-4 in freeze-fracture replicas of liver, brain, and spinal cord: factors limiting quantitative analysis. Cell Tiss Res 296:307-321.
26. Rash JE, Johnson TJA, Dinchuk JE, Duch DS, Levinson SR (1990) Labeling intramembrane particles in freeze-fracture replicas. In: Freeze-fracture studies of membranes (Hui SW, ed), pp 41-59. Boca Raton: CRC.
27. Rash JE, Dillman RK, Morita M, Whalen LR, Guthrie PB, Fay-Guthrie D (1995) Grid-mapped freeze fracture: correlative confocal laser scanning microscopy and freeze-fracture electron microscopy of preselected cells in tissue slices. In: Rapid freezing, freeze fracture, deep etching (Severs NJ, Shotton DM, eds), pp 127-150. New York: Wiley-Liss.
28. Rash JE, Duffy HS, Dudek FE, Bilhartz BL, Whalen LR, Yasumura T (1997) Grid-mapped freeze-fracture analysis of gap junctions in gray and white matter of adult rat central nervous system, with evidence for a "panglial syncytium" that is not coupled to neurons. J Comp Neurol 388:265-292.
29. Rash JE, Yasumura T, Hudson CS, Agre P, Nielsen S (1998). Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proc Natl Acad Sci USA 95:11981-11986.
30. Rash JE, Yasumura T, Dudek FE, Nagy JI (2001) Cell-specific expression of connexins and evidence of restricted gap junctional coupling between glial cells and between neurons. J Neurosci 21:1983-2000.
31. Sandri C, Van Buren JM, Akert K (1977) Membrane morphology of the vertebrate nervous system. Prog Brain Res 46:201-265.
32. Scherer SS, Deschênes SM, Xu Y-T, Grinspan JB, Fischbeck K, Paul DL (1995) Connexin 32 is a myelin-related protein in the PNS and CNS. J Neurosci 15:8281-8294.
33. Scherer SS, Xu Y-T, Nelles E, Fischbeck K, Willecke K, Bone LJ (1998) Connexin 32 null-mutant mice develop a demyelinating peripheral neuropathy. Glia 24:8-20.
34. Smart EJ, Graf GA, McNiven MA, Sessa WC, Engelman JA, Scherer PE, Okamoto T, Lisanti MP (1999) Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol 19:7289-7304.
35. Spray DC, Dermietzel R (1995) X-linked dominant Charcot-Marie-Tooth disease and other potential gap junction diseases of the nervous system. Trends Neurosci 18:256-262.
36. Staehelin LA (1974) Structure and function of intercellular junctions. Internat Rev Cytol 39:191-283.
37. Steere RL, Erbe EF, Moseley JM (1980) Prefracture and cold-fracture images of yeast plasma membranes. J Cell Biol 86:113-122.
38. Tetzlaff W (1982) Tight junction contact events and temporary gap junctions in the sciatic nerve fibres of the chicken during Wallerian degeneration and subsequent regeneration. J Neurocytol 11:839-858.
39. Webster HD (1971) The geometry of peripheral myelin sheaths during their formation and growth in rat sciatic nerves. J Cell Biol 48:348-367.
40. Webster HD, Favilla JT (1984) Development of peripheral nerve fibers. In: Peripheral neuropathy (Dyck JP, Thomas PK, Lambert EH, Bunge R, eds), Vol 1, Ch 15, pp 329-359. Philadelphia: Saunders.
41. Winkler H, Wildhaber H, Gross H (2002) Decoration on the surface of a regular protein layer. Ultramicroscopy 16:331-339.
42. Yoshimura T, Satake M, Kobayashi T (1996) Connexin43 is another gap junction protein in the peripheral nervous system. J Neurochem 67:1252-1258.
43. Zhao S, Fort A, Spray DC (1999) Characteristics of gap junction channels in Schwann cells from wild-type and connexin-null mice. Ann NY Acad Sci 883:533-537.