Glycine-Arginine-α-Ketoisocaproic Acid Improves Performance of Repeated Cycling Sprints

Medicine and Science in Sports and Exercise

Volumn 36, Issue 4, 2004, Pages 583-587

  Buford, Britni N ^a   Koch, Alexander J ^a  

^a TRUMAN STATE UNIVERSITY   (United States)

Author keywords

Amino acids; Exercise performance; Fatigue; Lactate; Supplementation

Indexed keywords

2 OXOISOCAPROIC ACID; ARGININE; GLYCINE; PLACEBO;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BICYCLE ERGOMETER; BLOOD SAMPLING; CONTROLLED STUDY; CYCLING; DIET SUPPLEMENTATION; DIETARY INTAKE; EXERCISE; HUMAN; HUMAN EXPERIMENT; LACTATE BLOOD LEVEL; MALE; NORMAL HUMAN; REST; TASK PERFORMANCE;

ADULT; BICYCLING; BIOMECHANICS; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; EXERCISE TEST; HEXANOIC ACIDS; HUMANS; LACTIC ACID; MALE; MUSCLE FATIGUE; MUSCLE, SKELETAL; PLACEBOS;

EID: 1842453235     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1249/01.MSS.0000122075.14060.C4     Document Type: Article

References (26)

1. ABERNETHY, P., G. WILSON, and P. LOGAN. Strength and power assessment. Issues, controversies and challenges. Sports Med. 19:401-417, 1995.
2. BLOMSTRAND, E., and B. SALTIN. Effect of muscle glycogen on glucose, lactate and amino acid metabolism during exercise and recovery in human subjects. J. Physiol. 514:293-302, 1999.
3. BROOKS, G. A., T. D. FAHEY, T. P. WHITE, and K. M. BALDWIN. Exercise Physiology: Human Bioenergetics and Its Applications, 3rd Ed. Boston: McGraw Hill, 2000.
4. BUCKSPAN, R., B. HOXWORTH, E. CERSOSIMO, J. DEVLIN, E. HORTON, and N. ABUMRAD. alpha-Ketoisocaproate is superior to leucine in sparing glucose utilization in humans. Am. J. Physiol. 251:E648-E653, 1986.
5. DENTON, R., and A. HALLESTRAP. Regulation of pyruvate metabolism in mammalian tissues. Essays Biochem. 15:37-77, 1979.
6. FIELDING, R. A., W. J. EVANS, V. A. HUGHES, L. L. MOLDAWER, and B. R. BISTRIAN. The effects of high intensity exercise on muscle and plasma levels of alpha-ketoisocaproic acid. Eur. J. Appl. Physiol. Occup. Physiol. 55:482-485, 1986.
7. HAFF, G. G., C. A. SCHROEDER, A. J. KOCH, K. E. KUPHAL, M. J. COMEAU, and J. A. POTTEIGER. The effects of supplemental carbohydrate ingestion on intermittent isokinetic leg exercise. J. Sports Med. Phys. Fitness 41:216-222, 2001.
8. INBAR, O., O. BAR-OR, and J. S. SKINNER. The Wingate Anaerobic Test. Champaign, IL: Human Kinetics, 1996.
9. JABLONOWSKY, R., O. INBAR, A. ROTSTEIN, and G. TENENBAUM. Evaluation of anaerobic performance capacity by the isokinetic Ariel computerized exercise system-reliability and validity. J. Sports Med. Phys. Fitness 32:262-270, 1992.
10. JEEVANANDAM, M., M. R. ALI, N. J. HOLADAY, J. K. WEIS, and S. R. PETERSEN. Relative nutritional efficacy of arginine and ornithine salts of alpha-ketoisocaproic acid in traumatized rats. Am. J. Clin. Nutr. 57:889-896, 1993.
11. KACZKOWSKI, W., D. L. MONTGOMERY, A. W. TAYLOR, and V. KLISSOURAS. The relationship between muscle fiber composition and maximal anaerobic power and capacity. J. Sports Med. Phys. Fitness 22:407-413, 1982.
12. KAMINSKI, T. W., M. D. GODFREY, R. W. BRAITH, and B. R. STEVENS. Measurement of acute dynamic anaerobic muscle fatigue using a novel fatigue resistance index. Isokinetics Exerc. Sci. 8:1-7, 2000.
13. LEWIS, S. F., and C. F. FULCO. A new approach to studying muscle fatigue and factors affecting performance during dynamic exercise in humans. Exerc. Sport Sci. Rev. 26:91-116, 1998.
14. MESA, J. L. M., J. R. RUIZ, M. M. GONZALEZ-GROSS, A. G. SAINZ, and M. J. GARZON. Oral creatine supplementation and skeletal muscle metabolism. Sports Med. 32:903-944, 2002.
15. MOGNONI, P., M. V. NARICI, M. D. SIRTORI, and F. LORENZELLI. Isokinetic torques and kicking maximal ball velocity in young soccer players. J. Sports Med. Phys. Fitness 34:357-361, 1994.
16. NISSEN, S., R. SHARP, M. RAY, et al. Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training. J. Appl. Physiol. 81:2095-2104, 1996.
17. NISSEN, S. L., and R. L. SHARP. Effect of dietary supplements on lean mass and strength gains with resistance exercise: a meta-analysis. J. Appl. Physiol. 94:651-659, 2003.
18. SANDSTEDT, S., L. JORFELDT, and J. LARSSON. Randomized, controlled study evaluating effects of branched chain amino acids and alpha-ketoisocaproate on protein metabolism after surgery. Br. J. Surg. 79:217-220, 1992.
19. STEVENS, B. R., M. D. GODFREY, T. W. KAMINSKI, and R. W. BRAITH. High-intensity dynamic human muscle performance enhanced by a metabolic intervention. Med. Sci. Sports Exerc. 32:2102-2108, 2000.
20. STIPANUK, M. H. and M. WATFORD. Amino acid metabolism. In: Biochemical and Physiological Aspects of Human Nutrition, M. H. Stipanuk (Ed.). Philadelphia: W. B. Saunders, 1999, pp. 233-286.
21. TARNOPOLSKY, M. A., S. A. ATKINSON, J. D. MAcDOUGALL, B. B. SENOR, P. W. LEMON, and H. SCHWARCZ. Whole body leucine metabolism during and after resistance exercise in fed humans. Med. Sci. Sports Exerc. 23:326-333, 1991.
22. THOMPSON, N. N., C. FOSTER, B. ROGOWSKI, and K. KAPLAN. Serial responses of anaerobic muscular performance in competitive athletes. Med. Sci. Sports Exerc. 18:51, 1986.
23. VAN HALL, G., G. J. VAN DER VUSSE, K. SODERLUND, and A. J. WAGENMAKERS. Deamination of amino acids as a source for ammonia production in human skeletal muscle during prolonged exercise. J. Physiol. 489:251-261, 1995.
24. WAGENMAKERS, A. J. Amino acid metabolism, muscular fatigue and muscle wasting. Speculations on adaptations at high altitude. Int J. Sports Med. 13(Suppl. 1):S110-S113, 1992.
25. WAGENMAKERS, A. J. Amino acid supplements to improve athletic performance. Curr. Opin. Clin. Nutr. Metab. Care 2:539-544, 1999.
26. WAGENMAKERS, A. J. Muscle amino acid metabolism at rest and during exercise. Diabetes Nutr. Metab. 12:316-322, 1999.