Preparing for Chemical Terrorism: Stability of Injectable Atropine Sulfate

Academic Emergency Medicine

Volumn 11, Issue 4, 2004, Pages 329-334

  Schier, Joshua G ^a,d   Ravikumar, Padinjarekuttu R ^b   Nelson, Lewis S ^a   Heller, Michael B ^b   Howland, Mary Ann ^c   Hoffman, Robert S ^a  

^a NEW YORK CITY POISON CONTROL CENTER   (United States)

^b New York City Poison Control   (United States)

^c ST JOHN'S UNIVERSITY   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Atropine; Drug stability; Organophosphate

Indexed keywords

2 PROPANOL; ATROPINE; BUFFER; DICHLOROMETHANE; PENTAFLUOROPROPANOL; PENTAFLUOROPROPIONIC ANHYDRIDE; PROPIONIC ACID; TROPINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CONCENTRATION RESPONSE; GAS CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; MASS SPECTROMETRY; NEUROTOXICITY; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; TERRORISM;

EID: 1842435252     PISSN: 10696563     EISSN: None     Source Type: Journal    
DOI: 10.1197/j.aem.2003.06.014     Document Type: Article

References (14)

1. Skolfield S, Lambert D, Tomassoni A, Wallace K. Inadequate regional supplies of antidotes and medications for poisoning emergencies [abstract]. J Toxicol Clin Toxicol. 1997; 35:467-575.
2. Dart RC, Stark Y, Fulton B, Koziol-McLain J, Lowenstein SR. Insufficient stocking of poisoning antidotes in hospital pharmacies. JAMA. 1996; 276:1508-10.
3. Sidell FR, Borak J. Chemical warfare agents: II. Nerve agents. Ann Emerg Med. 1992; 21:128-34.
4. Wisniewski W, Piasecka H. Investigation of atropine stability in injection solutions by determination with conductometric micromethod. Acta Pol Pharma. 1969; 26:304-12.
5. Lund W, Waaler T. The kinetics of atropine and apoatropine in aqueous solutions. Acta Chem Scand. 1968; 22:3085-97.
6. Lund U, Hansen SH. Simultaneous determination of atropine and its acidic and basic degradation products by mixed-column high-performance liquid chromatography. J Chromatogr. 1978; 161:371-8.
7. Lund W, Waaler T. The quantitative determination of atropine in presence of its hydrolysis and dehydration products. Pharm Acta Helv. 1970; 45:701-7.
8. Zvirblis P, Socholitsky I, Kondritzer AA. The kinetics of the hydrolysis of atropine. J Am Pharm Assoc Sci Ed. 1956; 45:450-4.
9. Paddle BM, Dowling MH. Simple high-performance liquid chromatographic method for assessing the deterioration of atropine-oxime mixtures employed as antidotes in the treatment of nerve poisoning. J Chromatogr. 1993; 648:373-80.
10. Kondritzer AA, Zvirblis P. Stability of atropine in aqueous solution. J Am Pharm Assoc Sci Ed. 1957; 46:531-5.
11. Zvirblis P, Ellin RI. Kinetics and stability of a multicomponent organophosphate antidote formulation in glass and plastic. J Pharm Sci. 1982; 71:321-5.
12. Clair P, Wiberg K, Granelli I, Carlsson Bratt I, Blanchet G. Stability study of a new antidote drug combination (Atropine-HI-6-Prodiazepam) for treatment of organophosphate poisoning. Eur J Pharm Sci. 2000; 9:259-63.
13. Drugs past their expiration date. Med Lett Drugs Ther. 2002; 44:93-4.
14. O'Neil MJ, Smith A, Heckelman PE, et al. (eds). The Merck Index. An Encyclopedia of Chemicals, Drugs, and Biologicals (ed 13). Whitehouse Station, NJ: Merck & Co., Inc., 2001, p 749.