Inhibitory effects of ent-kauranes from the stems of Annona squamosa on superoxide anion generation by human neutrophils

Planta Medica

Volumn 70, Issue 3, 2004, Pages 256-258

  Yang, Yu Liang ^a   Chang, Fang Rong ^a   Hwang, Tsong Long ^b   Chang, Wen Te ^b   Wu, Yang Chang ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA,17 DIHYDROXY KAURAN 19 AL; 16BETA,17 DIHYDROXY KAURAN 19 AL; ANNONA SQUAMOSA EXTRACT; KAURENE DERIVATIVE; KAURENOIC ACID; NITRIC OXIDE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANNONA; ANNONA SQUAMOSA; ANTIOXIDANT ACTIVITY; ARTICLE; ASSAY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; NEUTROPHIL; PLANT STEM; STRUCTURE ACTIVITY RELATION;

ADOLESCENT; ADULT; ANIMALS; ANNONA; DITERPENES, KAURANE; FREE RADICAL SCAVENGERS; HUMANS; MACROPHAGES; NEUTROPHILS; NITRIC OXIDE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT STEMS; RATS; SUPEROXIDES;

ANNONA; ANNONA SQUAMOSA; ANNONACEAE;

EID: 1842431875     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-815544     Document Type: Article

References (16)

1. Barton D, Nakanishi K, Meth-Cohn O. Comprehensive Natural Products Chemistry.: Vol. 2 Elsevier Science Ltd, Oxford: 1999: pp. 231-4
2. Somova LI, Shode FO, Moodley K, Govender Y. Cardiovascular and diuretic activity of kaurene derivatives of Xylopia aethiopica and Alepidea amatymbica. J Ethnopharmcol 2001; 77: 165-74
3. Van Wyk BE, Van Oudtshoorn B, Geriche N. Medicinal Plants of South Africa. Briza Publications. Pretoria: 1997: pp. 38-9
4. Wu YC, Hung YC, Chang FR, Cosentino M, Wang HK, Lee KH. Identification of ent-16β,17-dihydroxykauran-19-oic acid as an anti-HIV principle and isolation of the new diterpenoids annosquamosins A and B from Annona squamosa. J Nat Prod 1996; 59: 635-7
5. Fujita E, Node M. Diterpenoids of Rabdosia species. Fortschr Chem Org Naturst 1984; 46: 78-157
6. Chang FR, Yang PY, Lin JY, Lee KH, Wu YC. Bioactive kaurane diterpenoids from Annona glabra. J Nat Prod 1998; 61: 437-9
7. Chen CY, Chang FR, Cho CP, Wu YC. ent-Kaurane diterpenoids from Annona glabra. J Nat Prod 2000; 63: 1000-3
8. Yang YL, Chang FR, Wu CC, Wang WY, Wu YC. New ent-kaurane diterpenoids with anti-platelet aggregation activity from Annona squamosa. J Nat Prod 2002; 65: 1462-7
9. Chen CY, Chang FR, Wu YC. The constituents from the stems of Annona cherimola. J Chin Chem Soc 1997; 44: 313-9
10. Chen CY, Wu DY, Chang FR, Wu YC. Lignans and kauranes from the stems of Annona cherimola. J Chin Chem Soc 1998; 45: 629-34
11. Dahlgren C, Karlsson A. Respiratory burst in human neutrophils. J Immunol Methods 1999; 232: 3-14
12. Giang PM, Jin HZ, Son PT, Lee JH, Hong YS, Lee JJ. ent-Kaurane diterpenoids from Croton tonkinensis inhibit LPS-induced NF-κB activation and NO production. J Nat Prod 2003; 66: 1217-20
13. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 1968; 97: 77-89
14. Cross AR, Parkinson JF, Jones OT. The superoxide-generating oxidase of leucocytes NADPH-dependent reduction of flavin and cytochrome b in solubilized preparations. Biochem J 1984; 223: 337-44
15. Hwang TL, Wu CC, Guh JH, Teng CM. Potentiation of tumor necrosis factor-a expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway. Biochem Pharmacol 2003; 66: 149-56
16. 15N]nitrate in biological fluids. Anal Biochem 1982; 126: 131-8